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Drug: Tetracycline

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Total 14 results found since Jan 2013.

The mechanisms of minocycline in alleviating ischemic stroke damage and cerebral ischemia-reperfusion injury
Eur J Pharmacol. 2023 Jul 6:175903. doi: 10.1016/j.ejphar.2023.175903. Online ahead of print.ABSTRACTStroke is a group of diseases resulting from cerebral vascular rupture or obstruction and subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic stroke accounts for the majority of all stroke cases. The current treatments for ischemic stroke mainly include t-PA thrombolytic therapy and surgical thrombectomy. However, these interventions aimed at recanalizing cerebral vessels can paradoxically lead to ischemia-reperfusion injury, which exacerbates the severity of brain damage. Minocycli...
Source: European Journal of Pharmacology - July 8, 2023 Category: Drugs & Pharmacology Authors: Kemeng Zhao Pengwei Wang Xiaoguang Tang Na Chang Haonan Shi Longfei Guo Bingyi Wang Pengfei Yang Tiantian Zhu Xinghua Zhao Source Type: research

Tetracycline-, Doxycycline-, Minocycline-Induced Pseudotumor Cerebri and Esophageal Perforation
AbstractTetracyclines are a class of broad-spectrum bacteriostatic antibiotics used to treat many infections, including methicillin-resistantStaphylococcus aureus (MRSA), acne, pelvic inflammatory disease, chlamydial infections, and a host of zoonotic infections. These drugs work by inhibiting protein synthesis in bacterial ribosomes, specifically by disallowing aminoacyl-tRNA molecules from binding to the ribosomal acceptor sites. While rare, tetracycline antibiotics, particularly minocycline and doxycycline, are associated with an increased risk of developing esophageal perforation and pseudotumor cerebri (PTC, or idiopa...
Source: Advances in Therapy - February 10, 2023 Category: Drugs & Pharmacology Source Type: research

Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
This study identifies and characterizes a specific member of the miR-17 –92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged fem ales and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcome...
Source: Translational Stroke Research - April 27, 2022 Category: Neurology Source Type: research

Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1/STAT6 pathways.
CONCLUSION: Minocycline promoted microglial M2 polarization and inhibited M1 polarization, leading to neuronal survival and neurological functional recovery. The findings deepen our understanding of the mechanisms underlying minocycline-mediated neuroprotection in AIS. PMID: 33577892 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 9, 2021 Category: Drugs & Pharmacology Authors: Lu Y, Zhou M, Li Y, Li Y, Hua Y, Fan Y Tags: Biochem Pharmacol Source Type: research

Antineuroinflammation of Minocycline in Stroke
Accumulating research substantiates the statement that inflammation plays an important role in the development of stroke. Both proinflammatory and anti-inflammatory mediators are involved in the pathogenesis of stroke, an imbalance of which leads to inflammation. Anti-inflammation is a kind of hopeful strategy for the prevention and treatment of stroke. Substantial studies have demonstrated that minocycline, a second-generation semisynthetic antibiotic belonging to the tetracycline family, can inhibit neuroinflammation, inflammatory mediators and microglia activation, and improve neurological outcome. Experimental and clin...
Source: The Neurologist - June 24, 2017 Category: Neurology Tags: Review Article Source Type: research

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.Neuroimmunomodulation
Source: Neuroimmunomodulation - November 15, 2016 Category: Allergy & Immunology Source Type: research

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway
Conclusions: Minocycline inhibits HIF-1α-mediated cellular responses and protects BBB integrity through SIRT-3/PHD-2 pathway, proving to be a potential drug for the prevention and treatment of hypoxic brain injuries.
Source: Neuroscience - August 7, 2015 Category: Neuroscience Source Type: research

Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease
Compassionate use of doxycycline, a tetracycline antibiotic, in patients with Creutzfeldt-Jakob disease (CJD) revealed an increased survival of 4–7 months as compared with historical controls, a result not confirmed by a randomised, double blind, placebo-controlled trial.1 Is then therapy with doxycycline for patients with CJD over? The report of Assar et al2 on a single patient with variably protease-sensitive prionopathy (VPSPr),3 a rare subtype form of sporadic CJD, who received 4-year treatment with doxycycline at a relatively early stage of disease, suggests it is not and encourages novel studies on the use...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 12, 2015 Category: Neurosurgery Authors: Pocchiari, M., Ladogana, A. Tags: Dementia, Infection (neurology), Sleep disorders (neurology), Stroke, Variant Creutzfeld-Jakob Disease, Child and adolescent psychiatry, Memory disorders (psychiatry), Sleep disorders Editorial commentaries Source Type: research

Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.
Authors: Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T Abstract Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy ...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Minocycline Repurposing in Critical Illness: Focus on Stroke.
Abstract Stroke is a devastating disease associated with high morbidity and mortality. Despite the approved indication of systemic thrombolytic therapy in the United States for the acute management of ischemic stroke, its use is limited given a strict eligibility criteria and a risk for hemorrhagic transformation as a feared adverse effect. Many agents have been studied without success for neuroprotection in patients with stroke to reduce vascular injury and improve long-term functional outcomes. Minocycline is a tetracycline antibiotic that shows promise for its neuroprotective effects in multiple animal models a...
Source: Current Topics in Medicinal Chemistry - September 20, 2013 Category: Chemistry Authors: Vivian Liao T, C Forehand C, Hess DC, Fagan SC Tags: Curr Top Med Chem Source Type: research

MDEG Hyperactivation Induces Caspase-8 Activation Molecular Bases of Disease
Intracellular calcium overload plays a critical role in numerous pathological syndromes such as heart failure, brain ischemia, and stroke. Hyperactivation of the acid-sensing ion channels including degenerin/epithelial amiloride-sensitive sodium (DEG/ENaC) channels has been shown to elevate intracellular calcium and cause subsequent neuronal cell death that is independent of the canonical Egl-1/Ced-9/Ced-4/Ced-3 apoptotic pathway in Caenorhabditis elegans. In mammalian cells, hyperactivation of the DEG/ENaC channels can also lead to cell death, although the underlying mechanism remains largely unknown. Here, we use a tetra...
Source: Journal of Biological Chemistry - February 1, 2013 Category: Chemistry Authors: Pan, J.-A., Fan, Y., Gandhirajan, R. K., Madesh, M., Zong, W.-X. Tags: Cell Biology Source Type: research