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Drug: Baclofen
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Total 86 results found since Jan 2013.
Pisa-Like Syndrome Under Baclofen in a Patient With Spastic Hemiparesis due to Ischemic Stroke
Abstract: In its original description, Pisa syndrome was reported as an iatrogenic dystonia of the trunk caused by neuroleptic drugs. However, sometimes, not dystonic lateral flexion of the trunk is described as Pisa syndrome. These observations support the possibility of a drug-induced lateral flexion of the trunk with clinical presentation similar to Pisa syndrome, although with a different etiology and pathophysiology. Here, we describe the case of a male patient, with a previous ischemic stroke and residual spastic hemiparesis to the right side, who subacutely developed a dramatic lateral flexion of trunk (approximatel...
Source: Clinical Neuropharmacology - September 1, 2015 Category: Neurology Tags: Case Reports Source Type: research
Evaluation of a clinician worn device for the quantitative assessment of abnormal muscle tone type and severity (P5.178)
CONCLUSIONS: Quantitative measurements of abnormal muscle tone from a clinician worn device can distinguish type and severity of abnormal muscle tone. This device could improve assessment outcome measures, leading to improved clinical care and better evaluation of interventions for individuals with abnormal muscle tone. Study Supported by: National Institutes of Health National Institute of Neurological Disorders and Stroke (1R43NS076052-01A1).Disclosure: Dr. Brokaw has received personal compensation for activities with Great Lakes NeuroTechnologies as an employee. Dr. Itin has nothing to disclose. Dr. Heldman has received...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brokaw, E., Itin, I., Heldman, D., Giuffrida, J., Montgomery, E. Tags: Neuro-rehabilitation: Stroke Source Type: research
Drugs used to treat joint and muscle disease
Publication date: Available online 19 February 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): David G. Lambert Joint disease: Arthritis can be simply broken into osteoarthritis and rheumatoid arthritis (RA). Osteoarthritis is treated with symptomatic pain relief and surgery. RA is a chronic autoimmune disease that causes inflammation of joints (leading to their destruction), tissues around joints and other organ systems. Treatment (for pain) of RA in the first instance is with non-steroidal anti-inflammatory drugs, with second-line treatment using disease-modifying antirheumatic drugs (DMARDs). DMAR...
Source: Anaesthesia and intensive care medicine - February 24, 2015 Category: Anesthesiology Source Type: research
Effect of Intrathecal Baclofen Bolus Injection on Ankle Muscle Activation During Gait in Patients With Acquired Brain Injury
Conclusions. ITB bolus injection alters the activation of MG and TA during gait. However, the changes in muscle activation are not closely related to the changes in gait speed or resting muscle hypertonia. The analysis of ankle muscle activation during gait better characterizes the response to ITB bolus injection than gait kinematics.
Source: Neurorehabilitation and Neural Repair - December 24, 2014 Category: Neurology Authors: Chow, J. W., Yablon, S. A., Stokic, D. S. Tags: Clinical Research Articles Source Type: research
Mobility and Gait Outcomes Following Intensive Rehabilitation, Onabotulinumtoxin A, and Baclofen Treatment Chronic Post-Stroke: A Case Report
Source: Journal of Allied Health - December 11, 2014 Category: Universities & Medical Training Authors: Barakatt, EdwardColeman-Salgado, BryanMcKeough, MichaelMandeville, DavidGong, JillianMintz, EmilyThatch, JoshuaVourakis, AnastasiaThakur, Nicklesh Tags: Research Articles Source Type: research
Successful Use of Tetrabenazine in a Patient with Intractable Hiccups After Stroke
We describe the case of a 60‐year‐old man with a recent diagnosis of right insular ischemic stroke who presented with frequent, intense, and disabling hiccups for more than 1 month. As diagnosis of poststroke hiccups was assumed, the patient was treated over the next 6 months with adequate doses of various antipsychotic drugs commonly used for the treatment of hiccups; however, all were discontinued because of adverse effects. Indeed, dyskinesia after chlorpromazine (up to 75 mg/day for 4 wks), as well as somnolence and dyskinesia after haloperidol (up to 6 mg/day for 6 wks), somnolence after gabapentin (up to 18...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 4, 2014 Category: Drugs & Pharmacology Authors: Antonino Naro, Placido Bramanti, Rocco Salvatore Calabrò Tags: Case Report Source Type: research
Baclofen and gamma-hydroxybutyrate differentially altered behavior, EEG activity and sleep in rats
Conclusion: While both Bac and GHB induced a non-physiological resting state, only Bac facilitated and consolidated sleep, and promoted EEG delta oscillations thereafter. Hence, Bac can be considered a sleep-promoting drug and its effects on functional recovery after stroke can be evaluated both in humans and rats.
Source: Neuroscience - November 20, 2014 Category: Neuroscience Source Type: research
Baclofen for stroke patients with persistent hiccups: a randomized, double-blind, placebo-controlled trial
Preclinical studies suggest baclofen could be used in treating persistent hiccups in stroke patients. Here, the results of this randomised controlled trial provide evidential support for this, though the authors highlight the need for larger studies.
Source: Trials - July 22, 2014 Category: Journals (General) Authors: Cuie ZhangRuifen ZhangShuangyan ZhangMeiling XuShuyan Zhang Source Type: research
Subcutaneous Use of Baclofen
Painful spasticity is an often debilitating symptom that occurs mostly in patients with neurologic diseases such as multiple sclerosis or stroke. Treatment approaches include pharmacologic and nonpharmacologic interventions. Baclofen is one of the drugs commonly used to decrease elevated muscle tone. This GABAB agonist acts primarily by limiting the release of excitatory neurotransmitters on the spinal level, thereby decreasing spastic muscle tone. Baclofen is licensed for oral and intrathecal use in spasticity. The abrupt cessation of baclofen therapy can lead to withdrawal syndromes including epileptic seizures. Here, we...
Source: Journal of Pain and Symptom Management - May 30, 2014 Category: Palliative Care Authors: Constanze Rémi, Elisabeth Albrecht Tags: Letters Source Type: research
Adherence Associated With Oral Medications in the Treatment of Spasticity
Objective: To examine adherence to baclofen, tizanidine, and dantrolene (U.S. Food and Drug Administration–approved oral spasticity medications), and identified determinants of adherence.Design: A retrospective administrative claims data analysis that used medical and pharmacy claims data and enrollment information from a large, national U.S. health plan.Subjects and Methods: The subjects were commercial health plan members who initiated treatment on baclofen, tizanidine, or dantrolene from January 1, 2004, through September 30, 2009, and who had stroke, spinal cord injury, traumatic brain injury, cerebral palsy, or mult...
Source: PM and R - May 6, 2013 Category: Rehabilitation Authors: Rachel Halpern, Patrick Gillard, Glenn D. Graham, Sepideh F. Varon, Richard D. Zorowitz Tags: Original Research Source Type: research
Assessing the efficacy of different upper limb hemiparesis interventions on improving health-related quality of life in stroke patients: a systematic review.
CONCLUSION: The review demonstrates the need for upper limb intervention studies to focus on QOL as a primary outcome measure in addition to the functional outcomes currently used.
PMID: 23611858 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - March 1, 2013 Category: Neurology Authors: Pulman J, Buckley E Tags: Top Stroke Rehabil Source Type: research
