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Drug: Baclofen

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Total 86 results found since Jan 2013.

Assessing the efficacy of different upper limb hemiparesis interventions on improving health-related quality of life in stroke patients: a systematic review.
CONCLUSION: The review demonstrates the need for upper limb intervention studies to focus on QOL as a primary outcome measure in addition to the functional outcomes currently used. PMID: 23611858 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - March 1, 2013 Category: Neurology Authors: Pulman J, Buckley E Tags: Top Stroke Rehabil Source Type: research

Effect of oral baclofen on spasticity poststroke: responders versus non-responders.
Conclusion Although the responder rate was low, some participants responded to oral baclofen. Thus, a short-term trial of oral baclofen, and quantitative and electrophysiological assessments of muscle tone and ankle clonus are recommended. PMID: 29768106 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - May 16, 2018 Category: Neurology Authors: Mizuno S, Takeda K, Maeshima S, Shigeru S Tags: Top Stroke Rehabil Source Type: research

Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid.
This study was designed to compare the anti-spastic effect of waggle needling to the routine needling and to explore its underlying mechanism. We established post-stroke spasticity model based on ischemia stroke operation (middle cerebral artery occlusion). Rats were divided into six groups: normal control group, sham-operated control group, ischemia stroke model group, waggle needling group, routine needling group and baclofen group. Neurological function and muscle tone were assessed by the Zea Longa score and modified Ashworth scale, respectively. Indirect muscle tone was testified with electrophysiological recording. C...
Source: NeuroReport - June 9, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

Successful Use of Tetrabenazine in a Patient with Intractable Hiccups After Stroke
We describe the case of a 60‐year‐old man with a recent diagnosis of right insular ischemic stroke who presented with frequent, intense, and disabling hiccups for more than 1 month. As diagnosis of poststroke hiccups was assumed, the patient was treated over the next 6 months with adequate doses of various antipsychotic drugs commonly used for the treatment of hiccups; however, all were discontinued because of adverse effects. Indeed, dyskinesia after chlorpromazine (up to 75 mg/day for 4 wks), as well as somnolence and dyskinesia after haloperidol (up to 6 mg/day for 6 wks), somnolence after gabapentin (up to 18...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 4, 2014 Category: Drugs & Pharmacology Authors: Antonino Naro, Placido Bramanti, Rocco Salvatore Calabrò Tags: Case Report Source Type: research

Role of the continuous infusion test with an external pump for intrathecal baclofen in post-stroke spastic ambulatory patients
Discussion – conclusion Our pilot study showed that the continuous infusion test might be useful in order to evaluate the effect of different ITB doses in walking ability, helping the prediction of the appropriate candidates for ITB implantation.
Source: Annals of Physical and Rehabilitation Medicine - September 27, 2017 Category: Rehabilitation Source Type: research

Medtronic touts therapy delivered via SynchroMed pump in patients with post-stroke spasticity
Medtronic (NYSE:MDT)  touted data today showing that intrathecal baclofen therapy delivered via the company’s SychroMed II infusion pump performed better than the conventional treatment for patients with severe post-stroke spasticity. The medtech titan’s SynchroMed II pump is the only device approved in the U.S. for ITB therapy. Get the full story at our sister site, Drug Delivery Business News. The post Medtronic touts therapy delivered via SynchroMed pump in patients with post-stroke spasticity appeared first on MassDevice.
Source: Mass Device - January 11, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Neurological Pharmaceuticals Wall Street Beat Medtronic Source Type: news

New Study Shows Superiority of Intrathecal Baclofen Therapy (ITB Therapy(SM)) Over Oral Medication for the Treatment of Severe Post-Stroke Spasticity
Therapy Delivered via the Medtronic SynchroMed(TM) II Infusion System DUBLIN - January 11, 2018 -- (Healthcare Sales & Marketing Network) -- Medtronic plc (NYSE:MDT) today announced the publication of results from the 'Spasticity In Stroke-Randomised St... Devices, Drug Delivery, Neurology Medtronic, Intrathecal Baclofen Therapy, baclofen, SynchroMed, Stroke
Source: HSMN NewsFeed - January 11, 2018 Category: Pharmaceuticals Source Type: news

Baclofen for stroke patients with persistent hiccups: a randomized, double-blind, placebo-controlled trial
Preclinical studies suggest baclofen could be used in treating persistent hiccups in stroke patients. Here, the results of this randomised controlled trial provide evidential support for this, though the authors highlight the need for larger studies.
Source: Trials - July 22, 2014 Category: Journals (General) Authors: Cuie ZhangRuifen ZhangShuangyan ZhangMeiling XuShuyan Zhang Source Type: research

Evaluation of a clinician worn device for the quantitative assessment of abnormal muscle tone type and severity (P5.178)
CONCLUSIONS: Quantitative measurements of abnormal muscle tone from a clinician worn device can distinguish type and severity of abnormal muscle tone. This device could improve assessment outcome measures, leading to improved clinical care and better evaluation of interventions for individuals with abnormal muscle tone. Study Supported by: National Institutes of Health National Institute of Neurological Disorders and Stroke (1R43NS076052-01A1).Disclosure: Dr. Brokaw has received personal compensation for activities with Great Lakes NeuroTechnologies as an employee. Dr. Itin has nothing to disclose. Dr. Heldman has received...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brokaw, E., Itin, I., Heldman, D., Giuffrida, J., Montgomery, E. Tags: Neuro-rehabilitation: Stroke Source Type: research

Pisa-Like Syndrome Under Baclofen in a Patient With Spastic Hemiparesis due to Ischemic Stroke
Abstract: In its original description, Pisa syndrome was reported as an iatrogenic dystonia of the trunk caused by neuroleptic drugs. However, sometimes, not dystonic lateral flexion of the trunk is described as Pisa syndrome. These observations support the possibility of a drug-induced lateral flexion of the trunk with clinical presentation similar to Pisa syndrome, although with a different etiology and pathophysiology. Here, we describe the case of a male patient, with a previous ischemic stroke and residual spastic hemiparesis to the right side, who subacutely developed a dramatic lateral flexion of trunk (approximatel...
Source: Clinical Neuropharmacology - September 1, 2015 Category: Neurology Tags: Case Reports Source Type: research

Long-term Dosing of Intrathecal Baclofen in the Treatment of Spasticity after Acquired Brain Injury
Conclusion Despite the long-term use of ITB therapy in this cohort, the mean daily dose of intrathecal baclofen continued to require adjustments. There was no significant difference in the mean daily dose between patients with a diagnosis of TBI, stroke, or HIE. A complex dosing pattern was used more frequently in patients with stroke.
Source: PMandR - January 7, 2017 Category: Rehabilitation Source Type: research

New Partnership Forms to Develop Breakthrough Neuromodulation Device
WeHealth, an e-health department of Servier Group, said it is in a partnership with Pathmaker Neurosystems, a pioneering clinical-stage bioelectronic medicine company. The two companies revealed plans to develop and commercialize the first neuromodulation technology designed to treat muscle spasticity non-invasively. The new technology will be known as the MyoRegulator device. The new MyoRegulator PM-200 provides a non-invasive treatment option for patients suffering from muscle spasticity, a common condition found in many patients suffering from stroke, cerebral palsy, multiple sclerosis, spinal cord injury, and traumatic...
Source: MDDI - March 26, 2019 Category: Medical Devices Authors: Kristopher Sturgis Tags: Business Source Type: news

Intrathecal Baclofen Dosing Regimens: A Retrospective Chart Review
ConclusionSignificant differences in dosing were found between diagnoses and trended to differ by ambulatory status at the end of the study, and similar trends could be observed in achieving initial stable dose.
Source: Neuromodulation: Technology at the Neural Interface - October 1, 2015 Category: Biotechnology Authors: Jacob S. Clearfield, Mary Elizabeth S. Nelson, John McGuire, Lisa E. Rein, Sergey Tarima Tags: Clinical Research Source Type: research

Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.
In this study we compared the efficacy and safety of baclofen vs tolperisone in spasticity. One hundred fifty patients with cerebral palsy or post stroke or spinal cord injury associated spasticity were enrolled in present study. Group I comprised of Seventy-five patients receiving baclofen and group II comprised of 75 patients receiving tolperisone. For efficacy measurement 4 evaluation methods were used, 1) Modified Ashworth Scale for muscle tone, 2) Medical research council scale for muscle strength and 3) Barthel Index for functional outcome 4) Coefficient of efficacy. In efficacy evaluation, both groups showed signifi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 9, 2017 Category: Drugs & Pharmacology Authors: Agarwal S, Patel T, Shah N, Patel BM Tags: Biomed Pharmacother Source Type: research

A single, clinically relevant dose of the GABAB agonist baclofen impairs visuomotor learning.
This article is protected by copyright. All rights reserved. PMID: 33085094 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 21, 2020 Category: Physiology Authors: Johnstone A, Grigoras I, Petitet P, Capitão LP, Stagg CJ Tags: J Physiol Source Type: research