New Partnership Forms to Develop Breakthrough Neuromodulation Device

WeHealth, an e-health department of Servier Group, said it is in a partnership with Pathmaker Neurosystems, a pioneering clinical-stage bioelectronic medicine company. The two companies revealed plans to develop and commercialize the first neuromodulation technology designed to treat muscle spasticity non-invasively. The new technology will be known as the MyoRegulator device. The new MyoRegulator PM-200 provides a non-invasive treatment option for patients suffering from muscle spasticity, a common condition found in many patients suffering from stroke, cerebral palsy, multiple sclerosis, spinal cord injury, and traumatic brain injury. The condition results in certain muscles continuously contracting, resulting in an interference with normal movement, speech, and gait. Nader Yaghoubi, president and CEO of Pathmaker, says that the new technology was one of the first devices selected under the Expedited Access Pathway (EAP) program from FDA, a program intended for breakthrough medical devices. “The device is based on Pathmaker’s proprietary DoubleStim technology, which provides non-invasive stimulation simultaneously at spinal and peripheral sites associated with the targeted muscle,” he says. “This results in suppression of hyperexcitable spinal circuits found in patients with spasticity. The device is intended to be administered by a medical professional in a clinical setting, and treatments last 20 minu...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news

Related Links:

We report the case of a 37-year-old female patient, without past medical history, with multicystic lung disease in a context of chronic abdominal pain, fatigue and weight loss. After several months of diagnostic delay, pathological examination of surgical lung biopsies led to the diagnosis of secondary deposits of pancreatic cancer. The clinical and radiogical situation deteriorated quickly with the development of alveolar consolidation and Aspergillus superinfection was then diagnosed. This case illustrates the value of an early decision to undertake surgical lung biopsy in the work-up of multicystic lung disease when can...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
, Casadó V Abstract Dopaminergic and purinergic signaling play a pivotal role in neurological diseases associated with motor symptoms, including Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, Huntington disease, Restless Legs Syndrome (RLS), spinal cord injury (SCI), and ataxias. Extracellular dopamine and adenosine exert their functions interacting with specific dopamine (DR) or adenosine (AR) receptors, respectively, expressed on the surface of target cells. These receptors are members of the family A of G protein-coupled receptors (GPCRs), which is the largest protein superf...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
Abstract Restless legs syndrome (RLS) is a common sensory-motor circadian disorder, whose basic components include urge to move the legs, unpleasant sensory experience, and periodic leg movements during sleep, all associated with an enhancement of the individual's arousal state. Brain iron deficiency (BID) is considered to be a key initial pathobiological factor, based on alterations of iron acquisition by the brain, also moderated by genetic factors. In addition to the well-known dopaminergic involvement in RLS, previous studies pointed out that BID brings also a hyperglutamatergic state that influences a dysfunc...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
ConclusionHispidulin is a neuroprotective agent with clinical potential against IR-induced neurological injury.
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: These findings support the use of OMT as a method for the management of chronic constipation and DIOS in the CF population. However, because of the small population size, more research with larger populations is needed. PMID: 31233114 [PubMed - in process]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Authors: Larrimore C, Ramnot A, Jaghab A, Sarduy S, Guerrero G, Troccoli P, Hilton K, Bested A Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overal...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Authors: Ghanchi H, Miulli D, Kashyap S, Toor H, Farr S, Ray K, Ashraf N, Rao S, Sweiss R, Beamer Y Abstract Context: Opioids may be prescribed for the short-term management of acute-onset back pain in the setting of trauma or for long-term management of chronic back pain. More than 50% of regular opioid users report taking them for back pain. Objective: To investigate whether surgical intervention reduces opioid requirements by patients taking opioids for back pain and whether there is a difference between county and managed care hospitals in this postoperative reduction of opioid requirement. Methods: A r...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Publication date: August 2019Source: Biomedical Signal Processing and Control, Volume 53Author(s): Marco Pota, Massimo Esposito, Rosario Megna, Giuseppe De Pietro, Mario Quarantelli, Vincenzo Brescia Morra, Bruno AlfanoAbstractMultiple Sclerosis (MS) is a chronic neuroinflammatory disorder of the brain and spinal cord, widely studied nowadays, due to its relevant prevalence in the population. Even though no cure exists, an earlier and more adequate choice of treatment could delay its evolution and prevent irreversible sequelae and disability progression. Currently, Magnetic Resonance Imaging (MRI) represents an essential n...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: November 2019Source: Journal of Neurolinguistics, Volume 52Author(s): Noelia Do Carmo-Blanco, Michel Hoen, Stéphane Pota, Elsa Spinelli, Fanny MeunierAbstractNative listeners process and understand homophones, such as la locution ‘the phrase’ vs. l'allocution ‘the speech’, both [lalɔkysjɔ̃], without much semantical ambiguity in connected speech. Yet, behavioral experiments show that disambiguation is partial under intra-speaker variability without semantical context. To investigate electrophysiological correlates of perception of non-contrastive subphonemic features in Fr...
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 24 June 2019Source: Journal of Visceral SurgeryAuthor(s): A. Sokal, A. Sauvanet, B. Fantin, V. de LastoursSummaryAcute cholangitis is an infection of the bile and biliary tract which in most cases is the consequence of biliary tract obstruction. The two main causes are choledocholithiasis and neoplasia. Clinical diagnosis relies on Charcot's triad (pain, fever, jaundice) but the insufficient sensitivity of the latter led to the introduction in 2007 of a new score validated by the Tokyo Guidelines, which includes biological and radiological data. In case of clinical suspicion, abdominal ul...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
More News: Anaphylactic Shock | Back Pain | Baclofen | Brain | Cerebral Palsy | Clinical Trials | France Health | Funding | Hospitals | Medical Devices | Multiple Sclerosis | National Institutes of Health (NIH) | Neurology | Pain | Partnerships | Pneumonia | Spinal Cord Injury | Stroke