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Drug: Folic Acid
Nutrition: Vitamins

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Total 62 results found since Jan 2013.

Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First?
Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised.Summary: Hhcy is regarded as an independent predictor of cardiovascular morbidity and mortality in end-stage renal disease. Hhcy exerts its pathogenic action on the main processes involved in the progression of vascular damage. Research has shown Hhc...
Source: Cardiorenal Medicine - June 20, 2017 Category: Urology & Nephrology Source Type: research

B vitamins and cognition in subjects with small vessel disease: A Substudy of VITATOPS, a randomized, placebo-controlled trial
VITAmins TO Prevent Stroke (VITATOPS) study, a randomized, double-blind international multi-centre trial involving 8164 subjects in studying effect of lowering homocysteine level by daily administration of B-vitamins (2mg folic acid, 25mg vitamin B6, and 0.5mg vitamin B12) failed to demonstrate a positive effect of B-vitamins in reducing incidence of major vascular events and global cognition decline as measured by mini-mental state examination (MMSE) score [1,2]. However, assessment of cognition using MMSE alone has its limitations and a full neuropsychological assessment of different cognitive domains will provide more robust evidence.
Source: Journal of the Neurological Sciences - May 30, 2017 Category: Neurology Authors: Simon Kang Seng Ting, Arul Earnest, Huihua Li, Shahul Hameed, Hui Meng Chang, Christopher Li Hsian Chen, Eng-King Tan Tags: Letter to the Editor Source Type: research

B vitamins and cognition in subjects with small vessel disease: An extension study of VITATOPS, a randomized, placebo-controlled trial
VITAmins TO Prevent Stroke (VITATOPS) study, a randomized, double-blind international multi-centre trial involving 8164 subjects in studying effect of lowering homocysteine level by daily administration of B-vitamins (2mg folic acid, 25mg vitamin B6, and 0.5mg vitamin B12) failed to demonstrate a positive effect of B-vitamins in reducing incidence of major vascular events and global cognition decline as measured by mini-mental state examination (MMSE) score [1,2]. However, assessment of cognition using MMSE alone has its limitations and a full neuropsychological assessment of different cognitive domains will provide more robust evidence.
Source: Journal of the Neurological Sciences - May 30, 2017 Category: Neurology Authors: Simon Kang Seng Ting, Arul Earnest, Huihua Li, Shahul Hameed, Hui Meng Chang, Christopher Li Hsian Chen, Eng-King Tan Tags: Letter to the Editor Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Relationship Between Nutritional Factors and Hip Bone Density in Individuals with Chronic Stroke
AbstractThe aim of this study was to investigate the relationship between dietary habits and hip bone health in community-dwelling individuals with chronic stroke. The usual dietary intake of 94 individuals with chronic stroke (30 women, mean age: 59.0  years) was assessed by a 3-day food record within a single week. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at both hips. The results showed that low hip bone mass was found in 59 and 50 of the participants on the affected and unaffected side, respectively. The mean hip BMD was also significantly lower on the affected side than the unaf...
Source: Calcified Tissue International - April 17, 2017 Category: Orthopaedics Source Type: research

B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
Abstract Folates are B-vitamins that play an important role in brain function. Dietary and genetic deficiencies in folate metabolism result in elevated levels of homocysteine which have been linked to increased risk of developing a stroke. Reducing levels of homocysteine before or after a stroke through B-vitamin supplementation has been a focus of many clinical studies, however, the results remain inconsistent. Animal model systems provide a powerful mechanism to study and understand functional impact and mechanisms through which supplementation affects stroke recovery. The aim of this study was to understand the...
Source: Neurobiology of Disease - April 7, 2017 Category: Neurology Authors: Jadavji NM, Emmerson JT, MacFarlane AJ, Willmore WG, Smith PD Tags: Neurobiol Dis Source Type: research

Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) Vitamins, minerals, and phytochemicals
Conclusions: Enalapril–folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - April 3, 2017 Category: Nutrition Authors: Qin, X., Li, Y., He, M., Tang, G., Yin, D., Liang, M., Wang, B., Nie, J., Huo, Y., Xu, X., Hou, F. F. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research

How to Boost Your Stem Cells
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again… He's even started to regain sensation in his legs. And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy. During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord. Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair. His re...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news

Homocysteine and non-cardiac vascular disease.
Abstract Elevated homocysteine (Hcy) levels are predictors of cardiovascular disease (CVD). Hyperhomocysteinemia has also been associated with total and CVD mortality. However, whether Hcy is just a marker or plays a causal role in CVD remains to be elucidated. In this narrative review, we discuss the associations between Hcy and non-cardiac vascular diseases, namely stroke, peripheral artery disease (PAD), carotid artery disease, chronic kidney disease (CKD), atherosclerotic renal artery stenosis (ARAS), abdominal aortic aneurysm (AAA) and erectile dysfunction (ED). The effects of several drugs on Hcy levels are ...
Source: Current Pharmaceutical Design - March 17, 2017 Category: Drugs & Pharmacology Authors: Katsiki N, Perez-Martinez P, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

Fatal folic acid toxicity in humans - Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A.
Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingest...
Source: SafetyLit - March 11, 2017 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Fatal Folic Acid Toxicity in Humans.
Abstract Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23-year-old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic aci...
Source: Journal of Forensic Sciences - March 5, 2017 Category: Forensic Medicine Authors: Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A Tags: J Forensic Sci Source Type: research

Association between hyperhomocysteinemia and stroke with atherosclerosis and small artery occlusion depends on homocysteine metabolism-related vitamin levels in Chinese patients with normal renal function
This study was conducted to investigate the role of different homocysteine metabolism-related vitamin (HMRV) levels in the correlation between hyperhomocysteinemia (HHCY) and ischemic stroke (IS) subtypes. Three hundred and forty-eight IS patients manifesting different vascular subtypes were subclassified on the basis of HMRV deficiencies. Correlation between HHCY and IS subtypes was investigated in all the subgroups. In this study, HHCY was significantly correlated with the IS subtypes in large artery atherosclerosis (OR 1.126, 95%CI: 1.051  ~ 1.206,P = 0.001) and small artery occlusion (OR 1.105, 95%CI: 1.023 ~ 1.1...
Source: Metabolic Brain Disease - March 5, 2017 Category: Neurology Source Type: research

Folic acid supplementation and chronic kidney disease progression
In contrast to prior studies demonstrating no benefit or even increased harm from B vitamin supplementation in patients with chronic kidney disease, a large randomized trial from China recently demonstrated small but statistically significant reductions in the risk of first stroke and chronic kidney disease progression with the addition of folic acid to enalapril in adults with hypertension. Differences in the study population and study intervention may explain these discordant results.
Source: Kidney International - November 21, 2016 Category: Urology & Nephrology Authors: Christina M. Wyatt, J. David Spence Tags: Nephrology Digest Source Type: research

Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease The Renal Substudy of the China Stroke Primary Prevention Trial
In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m2 or greater, were randomized to receive a single tablet daily containing 10 mg enalapril and 0.8 mg folic acid (n = 7545) or 10 mg enalapril alone (n = 7559). Overall, 15 104 Chinese adults with a mean (range) age of 60 (45-75) years were recruited; median follow-up was 4.4 years. There were 164 and 132 primary events in the enalapril group and the enalapril-folic acid group, respectively. Compared with the enalapril group, the enalap...
Source: Nephrology Now - November 11, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Source Type: research

3 reasons your child shouldn’t go “gluten-free” (unless your doctor says so)
Follow me at @drClaire There is a puzzling and worrisome new phenomenon that I am seeing as a pediatrician: parents who are putting their children on gluten-free diets. It’s puzzling because in the vast majority of cases it isn’t necessary — and it’s worrisome because, although parents are doing it because they think it’s healthy, a gluten-free diet can be very unhealthy for children. Gluten is a protein found in wheat, rye, barley, and some other grains. It’s in bread and other baked goods, cereals, pastas — and in many other foods in small amounts. For people with celiac disease, even those small amounts ca...
Source: New Harvard Health Information - June 7, 2016 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Healthy Eating Parenting Source Type: news