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Drug: Diazepam

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Total 41 results found since Jan 2013.

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke
CONCLUSIONS: There is insufficient evidence to support the routine use of AEDs on the primary and secondary prevention of seizures after stroke. Further well-conducted studies are warranted for this important clinical problem.PMID:35129214 | DOI:10.1002/14651858.CD005398.pub4
Source: Cochrane Database of Systematic Reviews - February 7, 2022 Category: General Medicine Authors: Richard S Chang William Cy Leung Michael Vassallo Lucy Sykes Emma Battersby Wood Joseph Kwan Source Type: research

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
CONCLUSIONS: This review provides moderate-quality evidence that fails to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of people with acute stroke. More well-designed RCTs with large samples of participants with total anterior circulation syndrome are required to determine if there are benefits for this subgroup. Somnolence and rhinitis are frequent adverse events related to chlormethiazole. PMID: 30376593 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 30, 2018 Category: General Medicine Authors: Liu J, Zhang J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial
Conclusion: We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke.Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 19, 2021 Category: Neurology Source Type: research

Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke.
In conclusion, short-term DE was able to restore OD-plasticity in both adult and aging mice and even preserved plasticity after a cortical stroke, most likely mediated by reducing intracortical inhibition. PMID: 25220148 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - September 12, 2014 Category: Geriatrics Authors: Stodieck SK, Greifzu F, Goetze B, Schmidt KF, Löwel S Tags: Exp Gerontol Source Type: research

Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
Abstract: Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospective cohort study based on the medical records of 19 stroke patients presenting with status epilepticus to our institution. We measured the time between arrival at the hospital, the intravenous or intranasal administration of diazepam, and the seizure termination. Intranasal diazepam was administered about 9 times faster ...
Source: Medicine - February 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

Arginine NO-dependent and NO-independent effects on hemodynamics.
Abstract l-arginine administration decreases mean arterial blood pressure (MABP), presumably by excess nitric oxide (NO) synthesis. However, some reports indicate that d-arginine, not a substrate of NO synthase (NOS), also induces hypotension. To clarify this phenomenon, the hemodynamic effects of l- and d-arginine and their modification by NOS inhibition with l-nitroarginine methyl ester (l-NAME) were assessed. MABP, cardiac output, stroke volume, heart rate and systemic vascular resistance were recorded in Sprague-Dawley rats under urethane or ketamine/diazepam anesthesia, with or without blockade of NO synthesi...
Source: European Journal of Pharmacology - February 11, 2014 Category: Drugs & Pharmacology Authors: Guridi J, Borgatello C, Scremin OU Tags: Eur J Pharmacol Source Type: research

A Non-Epileptiform Event in the Course of rTMS: A Case for Close Physician Monitoring
We present the following case to demonstrate the importance of having physician supervision of patients undergoing repetitive transcranial magnetic stimulation (rTMS) treatments. The patient was a married 60-year-old male with a diagnosis of Major Depressive Disorder and Generalized Anxiety Disorder who had continuous symptoms of depression since the early 1980s despite receiving at least 7 adequate antidepressant treatments. The patient had several comorbid medical conditions. The patient did not have any previous history of seizure, stroke, an abnormal EEG, head injury, neurosurgical procedure, implanted devices, frequen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 29, 2013 Category: Neurology Authors: F. Andrew Kozel, Paul E. Croarkin, Kimberly S. Mapes Tags: Letters to the Editor Source Type: research

Comparison of the cardiorespiratory effects of a combination of ketamine and propofol, propofol alone, or a combination of ketamine and diazepam before and after induction of anesthesia in dogs sedated with acepromazine and oxymorphone.
Conclusions and Clinical Relevance-In dogs, K-P treatment maintained mean arterial blood pressure better than propofol alone and increased heart rate, cardiac output, or oxygen delivery, as did the K-D treatment. Supplemental 100% oxygen should be provided during IoA with all 3 treatments. PMID: 24564308 [PubMed - in process]
Source: American Journal of Veterinary Research - March 1, 2014 Category: Veterinary Research Authors: Henao-Guerrero N, Riccó CH Tags: Am J Vet Res Source Type: research

Re-evaluating Brain Death: The Potential for Treatment and Recovery after Brain Injury (P4.285)
Conclusions: Treatment-induced reversal of BD was evidenced by functional recovery across several domains. ACP neuromodulation optimizes cerebral functioning: electrical stimulation increases metabolic coupling; nutraceuticals promote healing, repair and neurotransmitter production while attenuating inflammatory cascades and free-radical damage. BD may not be definitively irreversible and deserves therapeutic consideration.Disclosure: Dr. Defina has nothing to disclose. Dr. Zakrzewski has nothing to disclose. Dr. Prestigiacomo has nothing to disclose. Dr. Machado has nothing to disclose. Dr. Bernad has nothing to disclose....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Defina, P., Zakrzewski, C., Prestigiacomo, C., Machado, C., Bernad, P., Halper, J., Fellus, J. Tags: Practice, Policy, and Ethics: Stroke, Critical Care, and Other Source Type: research

A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Abstract We previously showed that JM-20, a novel 1,5-benzodiazepine fused to a dihydropyridine moiety, possessed an anxiolytic profile similar to diazepam and strong neuroprotective activity in different cell models relevant to cerebral ischemia. Here, we investigated whether JM-20 protects against ischemic neuronal damage in vitro and in vivo. The effects of JM-20 were evaluated on hippocampal slices subjected to oxygen and glucose deprivation (OGD). For in vivo studies, Wistar rats were subjected 90 min of middle cerebral artery occlusion (MCAo) and oral administration of JM-20 at 2, 4 and 8 mg/kg 1 h fol...
Source: Neuropharmacology - June 19, 2014 Category: Drugs & Pharmacology Authors: Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL Tags: Neuropharmacology Source Type: research