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Drug: Enalapril
Nutrition: Vitamin B9
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Total 30 results found since Jan 2013.
Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive PatientsNovelty and Significance Clinical Trials
In conclusion, enalapril–folic acid therapy, compared with enalapril alone, significantly reduced the development of proteinuria in diabetic patients with hypertension.Clinical Trial Registration—URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00794885.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin Tags: Clinical Studies, Diabetes, Type 1, Diet and Nutrition, Hypertension Original Articles Source Type: research
Folic acid therapy reduces the risk of mortality associated with heavy proteinuria among hypertensive patients
Objective: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial.
Methods: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n = 10 348), or 10-mg enalapril alone (n = 10 354). All-cause mortality, a pr...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) Vitamins, minerals, and phytochemicals
Conclusions: Enalapril–folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - April 3, 2017 Category: Nutrition Authors: Qin, X., Li, Y., He, M., Tang, G., Yin, D., Liang, M., Wang, B., Nie, J., Huo, Y., Xu, X., Hou, F. F. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research
Longitudinal association between fasting blood glucose concentrations and first stroke in hypertensive adults in China: effect of folic acid intervention Cardiovascular disease risk
Conclusions: In Chinese hypertensive adults, an FBG concentration ≥7.0 mmol/L or diabetes is associated with an increased risk of first stroke; this increased risk is reduced by 34% with folic acid treatment. These findings warrant additional investigation. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - February 28, 2017 Category: Nutrition Authors: Xu, R. B., Kong, X., Xu, B. P., Song, Y., Ji, M., Zhao, M., Huang, X., Li, P., Cheng, X., Chen, F., Zhang, Y., Tang, G., Qin, X., Wang, B., Hou, F. F., Dong, Q., Chen, Y., Yang, T., Sun, N., Li, X., Zhao, L., Ge, J., Ji, L., Huo, Y., Li, J. Tags: Cardiovascular disease risk Source Type: research
Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT).
CONCLUSIONS: Enalapril-folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
PMID: 28148501 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 31, 2017 Category: Nutrition Authors: Qin X, Li Y, He M, Tang G, Yin D, Liang M, Wang B, Nie J, Huo Y, Xu X, Hou FF Tags: Am J Clin Nutr Source Type: research
Longitudinal association between fasting blood glucose concentrations and first stroke in hypertensive adults in China: effect of folic acid intervention.
CONCLUSIONS: In Chinese hypertensive adults, an FBG concentration ≥7.0 mmol/L or diabetes is associated with an increased risk of first stroke; this increased risk is reduced by 34% with folic acid treatment. These findings warrant additional investigation. This trial was registered at clinicaltrials.gov as NCT00794885.
PMID: 28122783 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 24, 2017 Category: Nutrition Authors: Xu RB, Kong X, Xu BP, Song Y, Ji M, Zhao M, Huang X, Li P, Cheng X, Chen F, Zhang Y, Tang G, Qin X, Wang B, Hou FF, Dong Q, Chen Y, Yang T, Sun N, Li X, Zhao L, Ge J, Ji L, Huo Y, Li J Tags: Am J Clin Nutr Source Type: research
Folic acid supplementation and chronic kidney disease progression
In contrast to prior studies demonstrating no benefit or even increased harm from B vitamin supplementation in patients with chronic kidney disease, a large randomized trial from China recently demonstrated small but statistically significant reductions in the risk of first stroke and chronic kidney disease progression with the addition of folic acid to enalapril in adults with hypertension. Differences in the study population and study intervention may explain these discordant results.
Source: Kidney International - November 21, 2016 Category: Urology & Nephrology Authors: Christina M. Wyatt, J. David Spence Tags: Nephrology Digest Source Type: research
Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease The Renal Substudy of the China Stroke Primary Prevention Trial
In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m2 or greater, were randomized to receive a single tablet daily containing 10 mg enalapril and 0.8 mg folic acid (n = 7545) or 10 mg enalapril alone (n = 7559). Overall, 15 104 Chinese adults with a mean (range) age of 60 (45-75) years were recruited; median follow-up was 4.4 years. There were 164 and 132 primary events in the enalapril group and the enalapril-folic acid group, respectively. Compared with the enalapril group, the enalap...
Source: Nephrology Now - November 11, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Source Type: research
Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients Clinical Sciences
Background and Purpose—We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from the CSPPT (China Stroke Primary Prevention Trial), a double-blind, randomized controlled trial.Methods—A total of 20 702 hypertensive adults without a history of major cardiovascular disease were randomly assigned to a double-blind daily treatment of an enalapril 10-mg and a folic acid 0.8-mg tablet or an enalapril 10-mg tablet alone. The primary outcome was first stroke.Results—The median treatment durat...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Qin, X., Li, J., Spence, J. D., Zhang, Y., Li, Y., Wang, X., Wang, B., Sun, N., Chen, F., Guo, J., Yin, D., Sun, L., Tang, G., He, M., Fu, J., Cai, Y., Shi, X., Ye, P., Chen, H., Zhao, S., Chen, M., Gao, C., Kong, X., Hou, F. F., Huang, Y., Huo, Y. Tags: Clinical Studies, Diet and Nutrition, Primary Prevention, Hypertension, Ischemic Stroke Original Contributions Source Type: research
Effect of folic acid supplementation on cancer risk among adults with hypertension in China: A randomized clinical trial
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - March 17, 2016 Category: Cancer & Oncology Authors: Xianhui Qin, Lin Shen, Rong Zhang, Youbao Li, Xiaobin Wang, Binyan Wang, Xiaodong Jiang, Hua Jiang, Yu Lei, Fan Fan Hou, Jin Gu, Yong Huo Tags: Research Article Source Type: research
Effect of folic acid supplementation on risk of new‐onset diabetes in adults with hypertension in China: Findings from the CSPPT
ConclusionsAmong adults with hypertension with no history of stroke and/or MI in China, folic acid supplementation had no significant effect on the risk of new‐onset diabetes. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes - October 11, 2015 Category: Endocrinology Authors: Xianhui Qin, Jianping Li, Yan Zhang, Dafang Chen, Binyan Wang, Mingli He, Jia Fu, Genfu Tang, Yefeng Cai, Xiuli Shi, Xin Xu, Fan Fan Hou, Xiaobin Wang, Yong Huo Tags: Original Article Source Type: research
In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke.
PMID: 26192588 [PubMed - in process]
Source: Annals of Internal Medicine - July 21, 2015 Category: Internal Medicine Authors: Barer D Tags: Ann Intern Med Source Type: research
Folic acid, a B vitamin, lowers stroke risk in people with high blood pressure
If you’re among the one in three American adults with high blood pressure, be sure you’re getting plenty of the B vitamin known as folate. Doing so may lower your odds of having a stroke, an often disabling or deadly event linked to high blood pressure, a new study suggests.
Folate occurs naturally in many foods, but especially green leafy vegetables, beans, and citrus fruits. Here in the United States, add to the list most grain products, including wheat flour, cornmeal, pasta, and rice. They are fortified with the synthetic version of folate, known as folic acid.
That’s not the case in many countries ar...
Source: New Harvard Health Information - March 18, 2015 Category: Consumer Health News Authors: Julie Corliss Tags: Drugs and Supplements Hypertension and Stroke high blood pressure Source Type: news
Folic acid supplementation among adults with hypertension reduces risk of stroke
(The JAMA Network Journals) In a study that included more than 20,000 adults in China with high blood pressure but without a history of stroke or heart attack, the combined use of the hypertension medication enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the American College of Cardiology Annual Scientific Session.
Source: EurekAlert! - Medicine and Health - March 15, 2015 Category: Global & Universal Source Type: news
Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China The CSPPT Randomized Clinical Trial
Conclusions and RelevanceAmong adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke. These findings are consistent with benefits from folate use among adults with hypertension and low baseline folate levels.Trial Registrationclinicaltrials.gov Identifier: NCT00794885
Source: JAMA - Journal of the American Medical Association - March 15, 2015 Category: Journals (General) Source Type: research
