Filtered By:
Drug: Gabapentin

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 42 results found since Jan 2013.

Treatment of hiccups in stroke rehabilitation with gabapentin: A case series and focused clinical review.
CONCLUSION: Evidence on the use of gabapentin for persistent or intractable hiccups is limited. This case series expands on the current literature by examining and comparing the current literature to our cases and exploring issues related to dosing, titration, side effects, and adjuncts to gabapentin. PMID: 33073739 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 17, 2020 Category: Neurology Authors: Got T, Vivas L, Fan C, MacNeill H Tags: Top Stroke Rehabil Source Type: research

Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke
AbstractStroke causes devastating sensory-motor deficits and long-term disability due to disruption of descending motor pathways. Restoration of these functions enables independent living and therefore represents a high priority for those afflicted by stroke. Here, we report that daily administration of gabapentin, a clinically approved drug already used to treat various neurological disorders, promotes structural and functional plasticity of the corticospinal pathway after photothrombotic cortical stroke in adult mice. We found that gabapentin administration had no effects on vascular occlusion, haemodynamic changes nor s...
Source: Brain - May 23, 2022 Category: Neurology Source Type: research

Pharmacological Management of Central Post-Stroke Pain: A Practical Guide
Abstract Pain is one of the most troublesome sequelae of stroke. Some of this post-stroke pain is caused by the brain lesion itself; this is called central post-stroke pain (CPSP). Although the prevalence of CPSP is low (1–8 %), persistent, often treatment-resistant, painful sensations are a major problem for stroke patients. The pathogenesis of CPSP remains unknown, but suggested underlying causes include hyperexcitation in the damaged sensory pathways, damage to the central inhibitory pathways, or a combination of the two. For pharmacological treatment, amitriptyline, an adrenergic antidepressant, is current...
Source: CNS Drugs - September 1, 2014 Category: Neurology Source Type: research

Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin
In this study, we first determined the relationship between the lesion site and changes in mechanical or thermal pain sensitivity in a rat CPSP model with experimental thalamic hemorrhage produced by unilateral intra-thalamic collagenase IV (ITC) injection. Then, we evaluated the efficacy of gabapentin (GBP), an anticonvulsant that binds the voltage-gated Ca2+ channel α2δ and a commonly used anti-neuropathic pain medication. Histological case-by-case analysis showed that only lesions confined to the medial lemniscus and the ventroposterior lateral/medial nuclei of the thalamus and/or the posterior thalamic nucleus result...
Source: Neuroscience Bulletin - November 5, 2014 Category: Neuroscience Source Type: research

Successful Use of Tetrabenazine in a Patient with Intractable Hiccups After Stroke
We describe the case of a 60‐year‐old man with a recent diagnosis of right insular ischemic stroke who presented with frequent, intense, and disabling hiccups for more than 1 month. As diagnosis of poststroke hiccups was assumed, the patient was treated over the next 6 months with adequate doses of various antipsychotic drugs commonly used for the treatment of hiccups; however, all were discontinued because of adverse effects. Indeed, dyskinesia after chlorpromazine (up to 75 mg/day for 4 wks), as well as somnolence and dyskinesia after haloperidol (up to 6 mg/day for 6 wks), somnolence after gabapentin (up to 18...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 4, 2014 Category: Drugs & Pharmacology Authors: Antonino Naro, Placido Bramanti, Rocco Salvatore Calabrò Tags: Case Report Source Type: research

A Medication Combination for the Treatment of Central Post-Stroke Pain (CPSP) via the Adjuvant use of Prednisone with Gabapentin: A Case Report
Publication date: Available online 25 September 2015 Source:PM&R Author(s): Luis Batlle, Ryan Mattie, Robert Irwin Case Description CPSP is a neuropathic pain syndrome that can occur from pathology of the brain. The case presented is of a female with multiple comorbidities and who was found to have an acute infarct in the left middle and anterior cerebral artery territories. She began to complain of worsening diffuse right upper and lower extremity pain, and central post-stroke pain was diagnosed. First-line agents were contraindicated due to medical comorbidities, and chronic kidney disease only permitted the...
Source: PMandR - September 26, 2015 Category: Rehabilitation Source Type: research

CO85 Association of Gabapentin Use with Functional Limitations Among Stroke Survivors: A Multi-Institutional Electronic Health Records Database Analysis
This study determines the effect of gabapentin on functional recovery measures such as mobility and GAIT abnormality among stroke survivors.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: M. Pathak, R. Neba, B. Zhou, R. Rasu, U. Sambamoorthi Source Type: research

Although pharmacological treatment may have beneficial effects in central post-stroke pain, it does not abolish the symptoms
Abstract The management of central post-stroke pain is challenging. Amitriptyline is considered the first-line pharmacological choice, with lamotrigine, gabapentin and pregabalin used as alternative therapies. If the therapeutic response with monotherapy is insufficient, combination therapy (e.g. an adrenergic antidepressant plus an antiepileptic) may be considered.
Source: Drugs and Therapy Perspectives - February 4, 2015 Category: Drugs & Pharmacology Source Type: research

A Medication Combination for the Treatment of Central Post-Stroke Pain (CPSP) via the Adjuvant use of Prednisone with Gabapentin: A Case Report
CPSP is a neuropathic pain syndrome that can occur from pathology of the brain. The case presented is of a female with multiple comorbidities and who was found to have an acute infarct in the left middle and anterior cerebral artery territories. She began to complain of worsening diffuse right upper and lower extremity pain, and central post-stroke pain was diagnosed. First-line agents were contraindicated due to medical comorbidities, and chronic kidney disease only permitted the use of low dose gabapentin.
Source: PM and R - September 23, 2015 Category: Rehabilitation Authors: Luis Batlle, Ryan Mattie, Robert Irwin Source Type: research

Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α 2 δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity
Abstract The α2δ-1 subunit of the voltage-gated Ca2+ channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic h...
Source: Neuroscience Bulletin - January 19, 2016 Category: Neuroscience Source Type: research

Serendipity and Observations in Functional Neurosurgery: From James Parkinson ’s Stroke to Hamani’s & amp; Lozano ’s Flashbacks
Background: Serendipity and observations have a noble tradition in medicine, including neurology, and are responsible for many medical treatments (carbamazepine for tic douloureux, amantadine for Parkinson ’s disease, gabapentin for restless legs…). We aimed at examining the contribution of serendipity and observations to functional neurosurgery. Scholarly publications relevant to the history of functional neurosurgery for movement and psychiatric disorders were reviewed, starting from the pre-ste reotactic era. The documents were scrutinized with respect to indications for surgery, surgical methods, and brain targets,...
Source: Stereotactic and Functional Neurosurgery - July 26, 2022 Category: Neurosurgery Source Type: research

Can I use DOAC in a patient with renal disease?
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His current medications include metformin, lisinopril, gabapentin, and aspirin. His most recent laboratories showed a creatinine 1.8, creatinine clearance (CrCl) 35 mL/min, hemoglobin 11g/dL, and international normalized ratio 1.0. His congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex (CHADSVASc) score is 4. Which medication should we use to prevent stroke in this patient?  Brief overview of the is...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Renal & Genitourinary Source Type: research

Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after thalamic hemorrhage: A case report.
Authors: Morinaga Y, Nii K, Sakamoto K, Inoue R, Mitsutake T, Hanada H Abstract Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Some studies have suggested that gabapentin may improve the symptoms of PSH. To our knowledge, this is the first case report demonstrating the efficacy of trazodone fo...
Source: Drug Discoveries and Therapeutics - July 23, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Thromboembolic Risks with Concurrent Direct Oral Anticoagulants and Antiseizure Medications: A Population-Based Analysis
ConclusionsAlthough CYP/P-gp-modulating antiseizure medications were associated with an increased risk of ischemic stroke when paired with DOAC in the primary analysis, such a phenomenon was not found among patients with epilepsy who took phenytoin, valproate, or levetiracetam with DOAC. Therefore, these antiseizure medication options among patients with epilepsy with concurrent DOAC should not be restricted solely based on their potential drug –drug interactions. Yet, the increased mortality during concurrent use of DOAC with phenytoin or valproate might call for caution.
Source: CNS Drugs - November 24, 2022 Category: Neurology Source Type: research

Restless Limbs Syndrome (RLS) Presenting as Hemisyndrome: A Case of Dejerine-Roussy Syndrome Responsive to Dopamine Agonists (P5.266)
CONCLUSION: Recognition of RLS as a hemisyndrome may offer new treatments for patients with chronic dysesthetic pain, paresthesia, and insomnia as illustrated in this case of DRS. RLS affects 10% of the population and DRS is seen in 10% after thalamic stroke. Pain associated with RLS may be contributing to chronic, persistent pain in patients with certain CNS lesions and may be treatable with Dopamine Agonists.Disclosure: Dr. Dickoff has received personal compensation for activities with UCB Pharma and Teva pharmaceuticals as a speaker.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dickoff, D. Tags: Movement Disorders: Sleep and Movement Disorders and Miscellaneous Diagnoses Source Type: research