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Drug: Namenda
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Total 38 results found since Jan 2013.
Memantine protects against ischemia/reperfusion ‐induced brain endothelial permeability
In conclusion, our results identified a novel function of memantine in maintaining brain vascular barrier function and suggested that memantine might be a potential therapeutic agent for the treatment of stroke. © 2018 IUBMB Life, 2018
Source: IUBMB Life - March 15, 2018 Category: Research Authors: Yingying Liu, Yudiao Huang, Yueyue Xu, Peng Qu, Minghua Wang Tags: Research Communication Source Type: research
Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice
The purpose of this study was to investigate the effects of memantine on brain ischemia. Because we can measure nitric oxide (NO) production and hydroxyl radical metabolism continuously, we investigated the effect of memantine on NO production and hydroxyl radical metabolism in cerebral ischemia and reperfusion.
Source: Journal of Stroke and Cerebrovascular Diseases - February 6, 2018 Category: Neurology Authors: Ai Tanaka, Yasuo Ito, Hitoshi Kawasaki, Chika Kitabayashi, Ryoji Nishioka, Masamizu Yamazato, Keisuke Ishizawa, Toshinori Nagai, Makiko Hirayama, Kazushi Takahashi, Toshimasa Yamamoto, Nobuo Araki Source Type: research
Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones
Publication date: Available online 13 October 2017 Source:Nitric Oxide Author(s): Meric A. Altinoz, İlhan Elmaci Glioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induces au...
Source: Nitric Oxide - October 13, 2017 Category: Chemistry Source Type: research
Pharmacotherapy for Vascular Cognitive Impairment
AbstractVascular cognitive impairment (VCI) is the second most common type of dementia after Alzheimer ’s disease (AD). Stroke and cardiovascular risk factors have been linked to both AD and VCI and potentially can affect cognitive function in mid and later life. Various pharmacological agents, including donepezil, galantamine, and memantine, approved for the treatment of AD have shown modest cogni tive benefits in patients with vascular dementia (VaD). However, their functional and global benefits have been inconsistent. Donepezil has shown some cognitive benefit in patients with VaD only, and galantamine has shown some...
Source: CNS Drugs - August 7, 2017 Category: Neurology Source Type: research
Memantine Attenuates Cell Apoptosis by Suppressing the Calpain-Caspase-3 Pathway in an Experimental Model of Ischemic Stroke.
Abstract
Ischemic stroke, the second leading cause of death worldwide, leads to excessive glutamate release, over-activation of N-methyl-D-aspartate receptor (NMDAR), and massive influx of calcium (Ca(2+)), which may activate calpain and caspase-3, resulting in cellular damage and death. Memantine is an uncompetitive NMDAR antagonist with low-affinity/fast off-rate. We investigated the potential mechanisms through which memantine protects against ischemic stroke in vitro and in vivo. Middle cerebral artery occlusion-reperfusion (MCAO) was performed to establish an experimental model of ischemic stroke. The neuropr...
Source: Experimental Cell Research - January 5, 2017 Category: Cytology Authors: Chen B, Wang G, Li W, Liu W, Lin R, Tao J, Jiang M, Chen L, Wang Y Tags: Exp Cell Res Source Type: research
Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia
Publication date: 1 April 2016 Source:Life Sciences, Volume 150 Author(s): Zheng-Zhen Chen, Dan-Dan Yang, Zhan Zhao, Hui Yan, Juan Ji, Xiu-Lan Sun Aims Memantine is a low-moderate affinity and uncompetitive N-methyl-d-aspartate receptor (NMDAR) antagonist, which is also a potential neuroprotectant in acute ischemic stroke for its particular action profiles. The present study was to reveal the mechanisms involved in the neuroprotection of memantine. Main methods We used a mouse model of permanent focal cerebral ischemia via middle cerebral artery occlusion to verify our hypothesis. 2,3,5-Triphenyltetrazolium chlori...
Source: Life Sciences - March 3, 2016 Category: Biology Source Type: research
A beacon of hope in stroke therapy—Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
Publication date: Available online 17 February 2016 Source:Pharmacology & Therapeutics Author(s): Ashfaqul Hoque, M. Iqbal Hossain, S. Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic C.H. Ng, Anderly Chueh, Carli Roulston, Heung-Chin Cheng Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal loss in acute and chronic neurological conditions such as ischaemic stroke, Alzheimer's and Huntington's diseases. Effective neuroprotective drugs to reduce excitotoxic neuronal loss in patients suffering from these neurological co...
Source: Pharmacology and Therapeutics - February 29, 2016 Category: Drugs & Pharmacology Source Type: research
A Beacon of Hope in Stroke Therapy - Blockade of Pathologically Activated Cellular Events in Excitotoxic Neuronal Death as Potential Neuroprotective Strategies
Publication date: Available online 17 February 2016 Source:Pharmacology & Therapeutics Author(s): Ashfaqul Hoque, M. Iqbal Hossain, Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic C.H. Ng, Anderly Chueh, Carli Roulston, Heung-Chin Cheng Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors is a major cause of neuronal loss in acute and chronic neurological conditions such as ischemic stroke, Alzheimer’s and Huntington’s diseases. Effective neuroprotective drugs to reduce excitotoxic neuronal loss in patients suffering from these neurological con...
Source: Pharmacology and Therapeutics - February 19, 2016 Category: Drugs & Pharmacology Source Type: research
Pharmacotherapy to Enhance Cognitive and Motor Recovery Following Stroke
Abstract
Stroke is a leading cause of disability among older adults and more than half of stroke survivors have some residual neurological impairment. Traditionally, managing the aftermath of stroke has been by the implementation of several physical and language therapy modalities. The limitations of these rehabilitation efforts have sparked an interest in finding other ways to enhance neurological recovery. Some of these novel approaches have included pharmacological interventions, cell-derived treatments, and cortical magnetic stimulation. Mounting evidence over the last 2 decades suggests that pharmacological ...
Source: Drugs and Aging - September 30, 2015 Category: Geriatrics Source Type: research
Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.
Abstract
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS...
Source: Brain and Language - April 28, 2015 Category: Neurology Authors: Barbancho MA, Berthier ML, Navas-Sánchez P, Dávila G, Green-Heredia C, García-Alberca JM, Ruiz-Cruces R, López-González MV, Dawid-Milner MS, Pulvermüller F, Lara JP Tags: Brain Lang Source Type: research
Memantine Treatment for Post-stroke Aphasia: A Case Control Study (P5.173)
CONCLUSION Memantine treatment showed no statistically significant improvement for patients with post-stroke aphasia based on FIM Scores for Motor and Cognition. Long-term follow-up and larger study groups, however, could provide additional information which may warrant further exploration into the benefits of memantine.Disclosure: Dr. Valles has nothing to disclose. Dr. Kennedy has nothing to disclose. Dr. Elashvili has nothing to disclose. Dr. Dohle has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Valles, J., Kennedy, J., Elashvili, M., Dohle, C. Tags: Neuro-rehabilitation: Stroke Source Type: research
The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects
obert Fern
Source: Journal of Cerebral Blood Flow and Metabolism - January 30, 2015 Category: Neuroscience Authors: Melissa TrotmanPhilipp VermehrenClaire L GibsonRobert Fern Tags: glutamate ischemia memantine NMDA receptor stroke Source Type: research
Combination of HBO and Memantine in Focal Cerebral Ischemia: Is There a Synergistic Effect?
In this study, we investigated whether or not MEM could prolong the narrow therapeutic window of HBO treatment. Transient focal cerebral ischemia was induced in male Sprague–Dawley rats by middle cerebral artery occlusion (MCAO) for 120 min. MCAO produced neurobehavioral deficits, increased infarction volume, increased Evans blue (EB) content and levels of pro-inflammatory factors, as well as depleted glutathione (GSH), and reduced catalase (CAT) and superoxide dismutase (SOD) activity in the ischemic ipsilateral hemisphere. The combination of 5 mg/kg MEM treatment 15 min after the onset of ischemic event and HBO ther...
Source: Molecular Neurobiology - October 30, 2014 Category: Neurology Source Type: research
