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Brain Plasticity After Stroke: The Potential Role of Memantine
No abstract available
Source: Neurosurgery - October 1, 2014 Category: Neurosurgery Tags: Science Times Source Type: research

The neuroprotective effect of 17β-estradiol is independent of its antioxidative properties.
CONCLUSION: E2 is equally neuroprotective as antagonization of NMDA receptors while E2 analogues without hormonal activity are not neuroprotective. Therefore the current data suggest that the neuroprotection activity of E2 is independent of its free-radical scavenging properties. PMID: 25148707 [PubMed - as supplied by publisher]
Source: Brain Research - August 20, 2014 Category: Neurology Authors: Gröger M, Plesnila N Tags: Brain Res Source Type: research

Alzheimer's Drug May Enhance Stroke Recovery Alzheimer's Drug May Enhance Stroke Recovery
Memantine may improve stroke outcomes in a non-neuroprotective way, preliminary research suggests. Medscape Medical News
Source: Medscape Today Headlines - August 5, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Stroke Rounds: Dementia Drug for Stroke Recovery?
(MedPage Today) -- The Alzheimer's disease drug memantine (Namenda) might be worth a look for improving recovery from stroke, a mouse-model study suggested.
Source: MedPage Today Cardiovascular - July 22, 2014 Category: Cardiology Source Type: news

Memantine Enhances Recovery From Stroke Basic Sciences
Conclusions— Our results suggest that memantine improves stroke outcomes in an apparently non-neuroprotective manner involving increased brain-derived neurotrophic factor signaling, reduced reactive astrogliosis, and improved vascularization, associated with improved recovery of sensory and motor cortical function. The clinical availability and tolerability of memantine make it an attractive candidate for clinical translation.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Lopez-Valdes, H. E., Clarkson, A. N., Ao, Y., Charles, A. C., Carmichael, S. T., Sofroniew, M. V., Brennan, K. C. Tags: Animal models of human disease, Imaging, Other imaging, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Effects Of Memantine And Clopidogrel Alone And In Combination On Cerebral Ischemia In Rats (P1.098)
Conclusions: We found that memantine and clopidogrel treatment reduces oxidative stress in HIBH but the combined treatment is less effective in reducing oxidative stress. Because of the potential pharmacokinetic mechanisms, combined therapy is less effective in reducing oxidative stress.Disclosure: Dr. Özdemir has nothing to disclose. Dr. Ilhan has nothing to disclose. Dr. Demir has nothing to disclose. Dr. Akgün has nothing to disclose. Dr. Kapan has nothing to disclose. Dr. Eser has nothing to disclose. Dr. Berilgen has nothing to disclose. Dr. Balduz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ozdemir, H., Ilhan, S., Demir, C., Akgun, B., Kapan, O., Eser, A., Berilgen, M. S., Balduz, M. Tags: Cerebrovascular Disease and Interventional Neurology: Translational Science Source Type: research

Memantine for Lewy Body Disorders: Systematic Review and Meta-Analysis.
CONCLUSION: Our results suggest that memantine did not have a benefit for the treatment of Lewy body disorders in cognition and motor function. However, memantine may be superior to placebo for the overall impression of the disorders. Further, memantine is well tolerated. PMID: 24406251 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - January 11, 2014 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Combined Treatment of Methylprednisolone Pulse and Memantine Hydrochloride Prompts Recovery from Neurological Dysfunction and Cerebral Hypoperfusion in Carbon Monoxide Poisoning: A Case Report
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral w...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki Tags: Case Reports Source Type: research

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