Filtered By:
Drug: Losartan

This page shows you your search results in order of date. This is page number 13.

Order by Relevance | Date

Total 204 results found since Jan 2013.

Serum Bicarbonate and Kidney Disease Progression and Cardiovascular Outcome in Patients With Diabetic Nephropathy: A Post Hoc Analysis of the RENAAL (Reduction of End Points in Non–Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan) Study and IDNT (Irbesartan Diabetic Nephropathy Trial)
Conclusions In this cohort of patients with type 2 diabetes with nephropathy, serum bicarbonate level associations with kidney disease end points were not retained after adjustment for estimated glomerular filtration rate, which is in contrast to results of earlier studies in nondiabetic populations.
Source: American Journal of Kidney Diseases - August 21, 2015 Category: Urology & Nephrology Source Type: research

Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.
CHRONIC ANTIHYPERTENSIVE TREATMENT IMPROVES PULSE PRESSURE BUT NOT LARGE ARTERY MECHANICS IN A MOUSE MODEL OF CONGENITAL VASCULAR STIFFNESS. Am J Physiol Heart Circ Physiol. 2015 Jul 31;:ajpheart.00288.2015 Authors: Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA Abstract Increased arterial stiffness is a common characteristic of humans with Williams-Beuren syndrome and mouse models of elastin insufficiency. Arterial stiffness is associated with multiple negative cardiovascular outcomes, including myocardial infarction, stroke and sudden death. Therefore, identifying therapeutic inter...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 31, 2015 Category: Physiology Authors: Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA Tags: Am J Physiol Heart Circ Physiol Source Type: research

Systolic Blood Pressure Control and Mortality After Stroke in Hypertensive Patients Clinical Sciences
Conclusions— Lower achieved SBP (<144 mm Hg) is associated with a significantly increased risk of cardiovascular and all-cause mortality after initial stroke in hypertensive patients during short-term follow-up. Further study is required to determine ideal SBP goals after stroke. Clinical Trial Registration— URL: http://clinicaltrials.gov/. Unique identifier: NCT00338260.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Okin, P. M., Kjeldsen, S. E., Devereux, R. B. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation
Conclusion: In hypertensive patients with ECG left ventricular hypertrophy with existing or new atrial fibrillation, digoxin use is not associated with a significantly increased risk of all-cause mortality after adjusting for other independent predictors of death and for the factors associated with the propensity to use digoxin in this population. These findings suggest that factors other than digoxin use may account for the increased mortality found with digoxin use in some studies. Clinical Trials Registration: http://clinicaltrials.gov/ct/show/NCT00338260?order=1
Source: Journal of Hypertension - June 5, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Aliskiren and losartan trial in non-diabetic chronic kidney disease
Conclusion: This study in non-diabetic CKD patients showed that combination therapy with aliskiren and ARB was as efficacious as aliskiren alone and ARB alone. There was one patient who developed a non-fatal stroke in the combined aliskiren and ARB group while the other two groups had none.
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Woo, K.-T., Choong, H.-L., Wong, K.-S., Tan, H.-K., Foo, M., Fook-Chong, S., Lee, E. J., Anantharaman, V., Lee, G. S., Chan, C.-M. Tags: Original Articles Source Type: research

Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Abstract Patients with hypertension have a high risk of ischemic stroke and subsequent stroke-associated pneumonia. Stroke-associated pneumonia is most likely to develop in patients with dysphagia. The present study was designed to compare the ameliorative effects of different treatments in rat model of dysphagia. Spontaneously hypertensive rats were treated with bilateral common carotid artery occlusion (BCAO) to induce chronic cerebral hypoperfusion causing disorders of the swallowing reflex. Angiotensin-converting enzyme (ACE) inhibitors (perindopril, imidapril and enalapril), an angiotensin II type 1-receptor ...
Source: European Journal of Pharmacology - November 12, 2014 Category: Drugs & Pharmacology Authors: Ikeda JI, Kojima N, Saeki K, Ishihara M, Takayama M Tags: Eur J Pharmacol Source Type: research

Pulse Pressure Is Useful for Determining the Choice of Antihypertensive Drugs in Postmenopausal Women
Objective: To assess the efficacy of various classes of antihypertensive drugs in postmenopausal women with hypertension using pulse pressure (PP) as an index. Patients and Methods: Selected women were required to be naturally menopausal for at least 1 year but not more than 5 years past their menstrual period. Exclusion criteria were a history of preeclampsia or eclampsia, a severe illness such as myocardial infarction or stroke within 6 months, the use of estrogens or progestins within 3 months, proteinuric nephropathy, and surgically induced menopause. There were 114 women who participated in this study after having giv...
Source: Pulse - November 6, 2014 Category: Cardiology Source Type: research

Visit-to-Visit Variability in Blood Pressure and Kidney and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Nephropathy: A Post Hoc Analysis From the RENAAL Study and the Irbesartan Diabetic Nephropathy Trial
Conclusions In diabetic individuals with nephropathy, systolic blood pressure visit-to-visit variability is associated independently with hard kidney disease outcomes.
Source: American Journal of Kidney Diseases - October 29, 2014 Category: Urology & Nephrology Source Type: research

BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model
Journal of Cerebral Blood Flow & Metabolism advance online publication, July 23 2014. doi:10.1038/jcbfm.2014.134 Author: Brian P Walcott
Source: Journal of Cerebral Blood Flow - July 23, 2014 Category: Neurology Authors: Brian P Walcott Tags: arteriovenous malformation losartan medical therapy stroke zebrafish Source Type: research

Four-Group Classification of Left Ventricular Hypertrophy Based on Ventricular Concentricity and Dilatation Identifies a Low-Risk Subset of Eccentric Hypertrophy in Hypertensive Patients Cardiomyopathies
Conclusions— Hypertensive patients with relatively mild LVH without either increased LV volume or concentricity have similar risk of all-cause mortality or cardiovascular events because hypertensive patients with normal LVM seem to be a low-risk group. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00338260.
Source: Circulation: Cardiovascular Imaging - May 20, 2014 Category: Radiology Authors: Bang, C. N., Gerdts, E., Aurigemma, G. P., Boman, K., de Simone, G., Dahlof, B., Kober, L., Wachtell, K., Devereux, R. B. Tags: Contractile function, Cardiovascular imaging agents/Techniques, Hypertrophy Cardiomyopathies Source Type: research

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function
This study assessed the potential therapeutic benefit of combining the mitochondria-specific antioxidant, MitoQ10, with the low-dose angiotensin receptor blocker (ARB), losartan, on attenuation of hypertension and left ventricular hypertrophy. In parallel, we investigated the impact of MitoQ10 on cardiac hypertrophy in a neonatal cardiomyocyte cell line. Methods and results:Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, n = 8–11) were treated with low-dose losartan (2.5 mg/kg per day); MitoQ10 (500 μmol/l); a combination of MitoQ10 and losartan (M + L); or vehicle for 8 weeks. Syst...
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Oxidative stress Source Type: research

Losartan prevents acquired epilepsy via TGF‐β signaling suppression
Abstract Objective: Acquired epilepsy is frequently associated with structural lesions following trauma, stroke and infections. While seizures are often difficult to treat, there is no clinically applicable strategy to prevent the development of epilepsy in patients at risk. We have recently shown that vascular injury is associated with activation of albumin‐mediated transforming growth factor β (TGF‐β) signaling, and followed by local inflammatory response and epileptiform activity ex vivo. Here we investigated albumin‐mediated TGF‐β signaling and tested the efficacy of blocking the TGF‐β pathway in preventi...
Source: Annals of Neurology - February 1, 2014 Category: Neurology Authors: Guy Bar‐Klein, Luisa P. Cacheaux, Lyn Kamintsky, Ofer Prager, Itai Weissberg, Karl Schoknecht, Paul Cheng, Soo Young Kim, Lydia Wood, Uwe Heinemann, Daniela Kaufer, Alon Friedman Tags: Research Article Source Type: research

Roles of Hypertension in the Rupture of Intracranial Aneurysms Basic Sciences
Conclusions— Normalization of blood pressure after aneurysm formation prevented aneurysmal rupture in mice. In addition, we found that the inhibition of the local renin–angiotensin system independent from the reduction of blood pressure can prevent aneurysmal rupture.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Tada, Y., Wada, K., Shimada, K., Makino, H., Liang, E. I., Murakami, S., Kudo, M., Kitazato, K. T., Nagahiro, S., Hashimoto, T. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats.
Abstract Prehypertension has been associated with adverse cerebrovascular events and brain damage. The aims of this study were to investigate ⅰ) whether short‑ and long-term treatments with losartan or amlodipine for prehypertension were able to prevent blood pressure (BP)-linked brain damage, and ⅱ) whether there is a difference in the effectiveness of treatment with losartan and amlodipine in protecting BP-linked brain damage. In the present study, prehypertensive treatment with losartan and amlodipine (6 and 16 weeks treatment with each drug) was performed on 4-week‑old stroke-prone spontaneously hypert...
Source: International Journal of Molecular Medicine - December 10, 2013 Category: Molecular Biology Authors: He DH, Zhang LM, Lin LM, Ning RB, Wang HJ, Xu CS, Lin JX Tags: Int J Mol Med Source Type: research

Comparison of the Effects of Amlodipine and Losartan on Blood Pressure and Diurnal Variation in Hypertensive Stroke Patients: A Prospective, Randomized, Double-Blind, Comparative Parallel Study.
CONCLUSIONS: The noninferiority of amlodipine was not confirmed by the per-protocol analysis. However, amlodipine showed a favorable effect on the morning surge. ClinicalTrials.gov identifier: NCT01830517. PMID: 24296324 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - November 29, 2013 Category: Drugs & Pharmacology Authors: Kwon HM, Shin JW, Lim JS, Hong YH, Lee YS, Nam H Tags: Clin Ther Source Type: research