Filtered By:
Drug: Losartan

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 204 results found since Jan 2013.

Aortic Root Dilatation in Hypertensive Patients with Left Ventricular Hypertrophy-Application of A New Multivariate Predictive Model. The Life Study
CONCLUSIONS: Using the proposed model the prevalence of AoR dilatation was equal in men and women and the model seems to address the effects of gender, age and body size on AoR size.CLINICAL TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT00338260.PMID:35345262 | DOI:10.31083/j.rcm2303095
Source: Reviews in Cardiovascular Medicine - March 29, 2022 Category: Cardiology Authors: Alexander Lilja-Cyron Casper N Bang Eva Gerdts Anne C Larstorp Sverre E Kjeldsen Stevo Julius Peter M Okin Kristian Wachtell Richard B Devereux Source Type: research

Effects of Blood Pressure Lowering Agents on Cardiovascular Outcomes in Weight Excess Patients: A Systematic Review and Meta-analysis
ConclusionsIn hypertensive subjects with excess weight, diuretics are more effective for preventing HF and stroke than CCB and ACEI, respectively. CCB are a good first-line choice for prevention of cardiovascular disease, except HF.
Source: American Journal of Cardiovascular Drugs - January 2, 2020 Category: Cardiology Source Type: research

Testing the Translational Power of the Zebrafish: An Interspecies Analysis of Responses to Cardiovascular Drugs
The zebrafish is rapidly emerging as a promising alternative in vivo model for the detection of drug-induced cardiovascular effects. Despite its increasing popularity, the ability of this model to inform the drug development process is often limited by the uncertainties around the quantitative relevance of zebrafish responses compared with non-clinical mammalian species and ultimately humans. Here we provide a comparative quantitative analysis of the in vivo cardiovascular responses of zebrafish, rat, dog, and human to three model compounds (propranolol, losartan, and captopril), which act as modulators of two key systems ...
Source: Frontiers in Pharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of early life AT1 blockade on adult cardiac morpho-functional changes and the renin-angiotensin system in a model of neonatal high oxygen-induced cardiomyopathy.
Abstract We previously reported that neonatal blockade of angiotensin II AT1 receptor prevents cardiac changes in 4 weeks rats with neonatal hyperoxia-induced cardiomyopathy, a recognized model of prematurity-related deleterious conditions. Considering the importance of AT1 receptor and the renin angiotensin system (RAS) in normal development, the present study aimed to investigate the adult effects of neonatal AT1 blockade on left ventricle (LV) in rats exposed to neonatal hyperoxia. Sprague-Dawley pups were exposed to 80% O2 or room air from days 3-10. AT1 blocker (losartan) or H2O were given by gavage from day ...
Source: European Journal of Pharmacology - July 30, 2019 Category: Drugs & Pharmacology Authors: Bonetto JHP, Fernandes RO, Dartora DR, Flahault A, Sonea A, He Y, Cloutier A, Belló-Klein A, Nuyt AM Tags: Eur J Pharmacol Source Type: research