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Total 276 results found since Jan 2013.

Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.
Abstract Stroke remains a leading cause of disability in the United States. Despite recent advances, interventions to reduce damage and enhance recovery after stroke are lacking. P2X4R, a receptor for adenosine triphosphate (ATP), regulates activation of myeloid immune cells (infiltrating monocytes/macrophages and brain-resident microglia) after stroke injury. However, over-stimulation of P2X4Rs due to excessive ATP release from dying or damaged neuronal cells can contribute to ischemic injury. Therefore, we pharmacologically inhibited P2X4R to limit the over-stimulated myeloid cell immune response and improve bot...
Source: Experimental Neurology - April 10, 2020 Category: Neurology Authors: Srivastava P, Cronin CG, Scranton VL, Jacobson KA, Liang BT, Verma R Tags: Exp Neurol Source Type: research

Predictors of 30-day hospital readmission after mechanical thrombectomy for acute ischemic stroke.
CONCLUSIONS: The study data demonstrate that hypertension, length of hospital stay, and hemorrhagic conversion were predictors of 30-day hospital readmission in stroke patients after mechanical thrombectomy. Infection was the most common cause of 30-day readmission, followed by cardiac and cerebrovascular diagnoses. These results therefore may serve to identify patients within the stroke population who require increased surveillance following discharge to reduce complications and unplanned readmissions. PMID: 32357335 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 30, 2020 Category: Neurosurgery Authors: Mouchtouris N, Al Saiegh F, Valcarcel B, Andrews CE, Fitchett E, Nauheim D, Moskal D, Herial N, Jabbour P, Tjoumakaris SI, Sharan AD, Rosenwasser RH, Gooch MR Tags: J Neurosurg Source Type: research

Mobile Stroke Units: Current and Future Impact on Stroke Care
Semin Neurol DOI: 10.1055/s-0040-1722724Ischemic stroke is a leading cause of death and major disability that impacts societies across the world. Earlier thrombolysis of blocked arteries with intravenous tissue plasminogen activator (tPA) and/or endovascular clot extraction is associated with better clinical outcomes. Mobile stroke units (MSU) can deliver faster tPA treatment and rapidly transport stroke patients to centers with endovascular capabilities. Initial MSU trials in Germany indicated more rapid tPA treatment times using MSUs compared with standard emergency room treatment, a higher proportion of patients treated...
Source: Seminars in Neurology - January 28, 2021 Category: Neurology Authors: Bowry, Ritvij Grotta, James C. Tags: Review Article Source Type: research

End-of-Life Care Decision-Making in Stroke
Stroke is one of the leading causes of death and long-term disability in the United States. Though advances in interventions have improved patient survival after stroke, prognostication of long-term functional outcomes remains challenging, thereby complicating discussions of treatment goals. Stroke patients who require intensive care unit care often do not have the capacity themselves to participate in decision making processes, a fact that further complicates potential end-of-life care discussions after the immediate post-stroke period. Establishing clear, consistent communication with surrogates through shared decision-m...
Source: Frontiers in Neurology - September 28, 2021 Category: Neurology Source Type: research

A Nursing Approach to Improving Critical Care Compliance With Vital Signs and Neurological Assessments in Post-IV-Alteplase Stroke Patients
Ischemic stroke represents 87% of all strokes. As global initiatives move forward with stroke care, health care providers and institutions will be called on to deliver the most current evidence-based care. The American Heart Association/American Stroke Association (AHA/ASA) estimates that 795 000 strokes occur each year; 610 000 are new strokes, and 185 000 are recurrent strokes. Eighty-seven percent are ischemic strokes; the overall mortality rate from stroke was 273 000, which makes stroke the fifth leading cause of death and the leading cause of disability in the United States. Stroke costs the United States an estimate...
Source: Critical Care Nursing Quarterly - August 23, 2022 Category: Nursing Tags: Original Articles Source Type: research

Implementation of an Advanced Practice Registered Nurse–Led Clinic to Improve Follow-up Care for Post–Ischemic Stroke Patients
CONCLUSION: An APRN-led clinic can improve follow-up care and may reduce unplanned 30-day readmissions for post–ischemic stroke patients. Further work is needed to determine the impact of alternative approaches such as telehealth.
Source: Journal of Neuroscience Nursing - September 10, 2022 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Conclusion: We successfully identified the ten hub shared genes linking the IS and MDD and constructed the regulatory networks for them that could serve as novel targeted therapy for the comorbidities.
Source: Frontiers in Genetics - March 31, 2023 Category: Genetics & Stem Cells Source Type: research

Empowering Stroke Survivors: Understanding The Role of Multidisciplinary Rehabilitation
Stroke is 1 of the leading causes of disability worldwide, with someone having a stroke every 40 seconds in the United-States.1 A stroke can occur by clot that interrupts blood flow in the brain. It can also be caused by a burst of a blood vessel that causes bleeding in the brain. There are also other unknown causes of stroke which occur less frequently. A stroke causes brain cells to die as they no longer receive oxygen and nutrients from the blood. Some of the most common risk factors of stroke are high blood pressure, high cholesterol, heart diseases, diabetes, smoking, physical inactivity, and obesity.
Source: Archives of Physical Medicine and Rehabilitation - April 24, 2023 Category: Rehabilitation Tags: INFORMATION/EDUCATION PAGE Source Type: research

Stroke prevention and the future of stroke care
Stroke is the fifth leading cause of death in the United States. The Georgia Department of Public Health reports the state had the 12th highest stroke death rate in the country. Georgia is also part of the “stroke belt,” an area of the southeastern United States with stroke death rates 30% higher than the rest of the nation. As the leading — but preventable — cause of disability, stroke can happen at any age. Stroke is a medical emergency, meaning the blood flow to an area of the brain…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 19, 2023 Category: Pharmaceuticals Source Type: news

Trends in deaths and disability-adjusted life-years of stroke attributable to high body-mass index worldwide, 1990 –2019
ConclusionA range of indicators for the global burden of stroke attributable to HBMI have been on the rise for the past three decades. Tremendous efforts worldwide should be in place to control and treat stroke attributable to HBMI, especially in regions with high-middle and middle SDIs and among middle-aged and aged populations.
Source: Frontiers in Neurology - June 30, 2023 Category: Neurology Source Type: research

Woodrow Wilson's hidden stroke of 1919: the impact of patient-physician confidentiality on United States foreign policy.
Abstract World War I catapulted the United States from traditional isolationism to international involvement in a major European conflict. Woodrow Wilson envisaged a permanent American imprint on democracy in world affairs through participation in the League of Nations. Amid these defining events, Wilson suffered a major ischemic stroke on October 2, 1919, which left him incapacitated. What was probably his fourth and most devastating stroke was diagnosed and treated by his friend and personal physician, Admiral Cary Grayson. Grayson, who had tremendous personal and professional loyalty to Wilson, kept the severit...
Source: Neurosurgical Focus - July 1, 2015 Category: Neurosurgery Authors: Menger RP, Storey CM, Guthikonda B, Missios S, Nanda A, Cooper JM Tags: Neurosurg Focus Source Type: research

Cryptogenic Stroke and Patent Foramen Ovale Risk Assessment
Publication date: Available online 29 June 2017 Source:Interventional Cardiology Clinics Author(s): Emiliya Melkumova, David E. ThalerTeaser Stroke is a devastating condition. It is the fifth leading cause of death in the United States, and a leading cause of serious long-term disability. Stroke occurs at any age. Younger patients tend to have strokes of undetermined cause, termed cryptogenic. Herein, the authors describe the classification of stroke cause; the risk of recurrent cryptogenic stroke with patent foramen ovale (PFO); a risk assessment model to stratify incidental versus a pathogenic PFO in patients presenting...
Source: Interventional Cardiology Clinics - June 30, 2017 Category: Cardiology Source Type: research

Ischemic Stroke: Management by the Nurse Practitioner
This article addresses preischemic stroke, acute, and postischemic stroke care by the NP with a focus on the American Heart Association 8 D ’s of stroke chain of survival.
Source: The Journal for Nurse Practitioners - November 10, 2018 Category: Nursing Authors: Susan E. Wilson, Susan Ashcraft Tags: Featured Article Source Type: research

Stroke impact symptoms are associated with sleep-related impairment
In the United States, the economic burden of stroke is more than $72 billion annually.1 Stroke is a leading cause of disability worldwide,2 and approximately 40% of stroke survivors have some degree of lingering functional impairment.3 Stroke survivors often experience stroke impact symptoms in such domains as motor function, cognition, communication, mood, activities of daily living, and social participation4,5 which limit their ability to return home or to work and improve their quality of life.
Source: Heart and Lung - December 11, 2019 Category: Intensive Care Authors: Eeeseung Byun, Ruth Kohen, Kyra J. Becker, Catherine J. Kirkness, Sandeep Khot, Pamela H. Mitchell Source Type: research

Spirituality and resilience among family  caregivers of survivors of stroke: A scoping review.
CONCLUSIONS: Spirituality and resilience following stroke are essential factors in caregiver adjustment following stroke. Further research with a focus on causality and the link between spirituality, resilience and adjustment in this population is needed. PMID: 32039873 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - February 11, 2020 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research