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Total 276 results found since Jan 2013.

Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
AbstractPurpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the United States, of which 87% are ischemic in nature. In addition to the management of modifiable high-risk factors to reduce the risk of recurrent stroke, antithrombotic agents (antiplatelets and anticoagulants) play an important role in secondary stroke prevention. This review will discuss the published literature on the use of antiplatelets and anticoagulants in secondary prevention of acute ischemic stroke and transient ischemic attack (TIA), ...
Source: Current Neurology and Neuroscience Reports - April 11, 2023 Category: Neuroscience Source Type: research

CERENOVUS Launches New Suite of Technologies to Advance Stroke Treatment
IRVINE, CA – September 9, 2020 – CERENOVUS, part of Johnson & Johnson Medical Devices Companies* today announced that it has launched CERENOVUS Stroke Solutions™, which includes a suite of three devices designed to aid physicians in clot removal procedures. The announcement was made during the virtual European Society of Minimally Invasive Neurological Therapy (ESMINT).Strokes are the second leading cause of death globally, and account for an estimated 140,000 deaths in the United States each year.[i],[ii] Over half of stroke survivors become chronically disabled placing an estimated $34 billion economic burden o...
Source: Johnson and Johnson - September 9, 2020 Category: Pharmaceuticals Source Type: news

Caveolin-1 in stroke neuropathology and neuroprotection: a novel molecular therapeutic target for ischemic-related injury.
Abstract Cardiovascular disease and associated cerebral stroke are a global epidemic attributed to genetic and epigenetic factors, such as diet, life style and an increasingly sedentary existence due to technological advances in both the developing and developed world. There are approximately 5.9 million stroke-related deaths worldwide annually. Current epidemiological data indicate that nearly 16.9 million people worldwide suffer a new or recurrent stroke yearly. In 2014 alone, 2.4% of adults in the United States (U.S.) were estimated to experience stroke, which is the leading cause of adult disability and the fi...
Source: Current Vascular Pharmacology - February 5, 2018 Category: Drugs & Pharmacology Authors: Wang S, Head BP Tags: Curr Vasc Pharmacol Source Type: research

Use of Outpatient Rehabilitation Among Adult Stroke Survivors - 20 States and the District of Columbia, 2013, and Four States, 2015.
Abstract Stroke is a leading cause of mortality and disability in the United States (1,2). Approximately 800,000 American adults experience a stroke each year (2,3). Currently, approximately 6 million stroke survivors live in the United States (2). Participation in stroke rehabilitation (rehab), which occurs in diverse settings (i.e., in-hospital, postacute care, and outpatient settings), has been determined to reduce stroke recurrence and improve functional outcomes and quality of life (3,4). Despite longstanding national guidelines recommending stroke rehab, it remains underutilized, especially in the outpatient...
Source: MMWR Morb Mortal Wkl... - May 25, 2018 Category: Epidemiology Authors: Ayala C, Fang J, Luncheon C, King SC, Chang T, Ritchey M, Loustalot F Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Management of Acute Ischemic Stroke
Conclusions: Appropriate treatment of ischemic stroke is essential in the reduction of mortality and morbidity. Management of stroke involves a multidisciplinary approach that starts and extends beyond hospital admission.
Source: Critical Care Medicine - October 14, 2020 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research

Pregnancy-Related Stroke: A Review
Conclusions and Relevance Early recognition and management are integral in decreasing the morbidity and mortality associated with a stroke in pregnancy. Relevance Statement This study was an evidence-based review of stroke in pregnancy and how to diagnose and mange a pregnancy complicated by a stroke. Target Audience Obstetricians and gynecologist, family physicians Learning Objectives After completing this learning activity, the participant should be better able to identify the pregnancy-related risk factors for a stroke; explain the presenting signs and symptoms of a stroke in pregnancy; describe...
Source: Obstetrical and Gynecological Survey - June 1, 2022 Category: OBGYN Tags: CME ARTICLES Source Type: research

Trends in stroke incidence in the United States: Will women overtake men?
Stroke poses a heavy burden on health systems, with serious implications for societies and economies. At the global level, stroke is the second leading cause of death and the third most common cause of disability.1 In the United States, about 795,000 strokes occur every year: on average, someone has a stroke every 40 seconds and someone dies as a result of a stroke every 4 minutes.2 Stroke incidence and mortality rates have decreased in the last decades3; however, the aging of populations and improvements in stroke management have resulted in higher numbers of people experiencing a stroke, and more stroke survivors requiri...
Source: Neurology - September 4, 2017 Category: Neurology Authors: Koton, S., Rexrode, K. M. Tags: EDITORIALS Source Type: research

Current advances in ischemic stroke research and therapies
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Derek Barthels, Hiranmoy DasAbstractWith more than 795,000 cases occurring every year, stroke has become a major problem in the United States across all demographics. Stroke is the leading cause of long-term disability and is the fifth leading cause of death in the US. Ischemic stroke represents 87% of total strokes in the US, and is currently the main focus of stroke research. This literature review examines the risk factors associated with ischemic stroke, changes in cell morphology and s...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - September 16, 2018 Category: Molecular Biology Source Type: research

Community-Based Stroke Recognition Education and Response: An Evidence-Based Intervention Project.
CONCLUSIONS: FAST was simple to teach and engaging for participants. Using the FAST curriculum in senior center populations increased the participants' awareness of stroke signs and symptoms, and their willingness to activate the 911 emergency system. IMPLICATIONS FOR PRACTICE: Educational interventions in the community with older adults can produce increased awareness of stroke symptoms and willingness to respond when necessary. PMID: 30567968 [PubMed - in process]
Source: Creative Nursing - November 1, 2018 Category: Nursing Authors: Sposito J, Zipf A, Alhowaymel F, Almutairi MT, Breda K Tags: Creat Nurs Source Type: research

Roles of integrins and extracellular matrix in stroke.
Abstract Ischemic stroke is a leading cause of death and disability in the United States, but recent advances in treatments (i.e. endovascular thrombectomy and tissue plasminogen activator (t-PA)) that target the stroke-causing blood clot, while improving overall stroke mortality rates, have had much less of an impact on overall stroke morbidity. This may in part be attributed to the lack of therapeutics targeting reperfusion induced injury after the blood clot has been removed, which, if left unchecked, can expand injury from its core into the surrounding at risk tissue (penumbra). This occurs in two phases of in...
Source: Am J Physiol Cell Ph... - November 21, 2018 Category: Cytology Authors: Edwards D, Bix GJ Tags: Am J Physiol Cell Physiol Source Type: research

Nerve stimulation could provide new treatment option for most common type of stroke
Research led by a UCLA scientist found that a new nerve stimulation therapy to increase blood flow could help patients with the most common type of stroke up to 24 hours after onset.A study of 1,000 patients found evidence that the technique, called active nerve cell cluster stimulation, reduced the patients ’ degree of disability three months after they suffered an acute cortical ischemic stroke, which affects the surface of the brain.Dr. Jeffrey Saver, director of theUCLA Comprehensive Stroke Center, was the co-principal investigator of the study, which was conducted at 73 medical centers in 18 countries.“We believe ...
Source: UCLA Newsroom: Health Sciences - May 24, 2019 Category: Universities & Medical Training Source Type: news

Time to Target Stroke: Examining the Circadian System in Stroke.
Authors: Stubblefield JJ, Lechleiter JD Abstract Stroke is the 5th leading cause of death in the United States and a leading cause of long-term disability. Ischemic strokes account for 87 percent of total stroke cases, yet the only FDA-approved treatments involve disruption of the blood clot to restore blood flow. New treatments aimed at saving or protecting neural tissue have largely failed in clinical trials and so new methodology or targets must be found. The occurrence of strokes significantly increases between 6 AM and 12 PM, implicating the circadian system in the onset of this debilitating brain injury. But ...
Source: The Yale Journal of Biology and Medicine - July 1, 2019 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Intraoperative Ischemic Stroke in Elective Spine Surgery: A Retrospective Study of Incidence and Risk
Conclusion. . With the increase of spinal procedures, it is important to identify patients at risk for having an ischemic stroke and to optimize their comorbidities preoperatively. Patients with intraoperative ischemic stroke carry a higher risk for morbidity and mortality during the index hospitalization. Level of Evidence: 4
Source: Spine - January 8, 2020 Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research

Impact of a Structured Response and Evidence-Based Checklist on In-hospital Stroke Outcomes
CONCLUSIONS Use of a checklist during inpatient stroke events can potentially increase adherence to guidelines for appropriate treatment and reduce mortality. Hospital response teams should consider use of a structured response system with an evidence-based checklist for high-acuity, low-frequency events such as in-hospital stroke.
Source: Journal of Neuroscience Nursing - April 29, 2020 Category: Neuroscience Tags: Article Source Type: research

"Personal road map for recovery:" examining the therapeutic use of weblogs by stroke survivors with aphasia.
CONCLUSION: Weblog writing was therapeutic for stroke survivors with aphasia. Authors reported benefits across cognitive, psychological, emotional, and social domains. Health professionals should consider recommending weblog writing, journaling, or other methods of writing for stroke survivors with aphasia. Implications for rehabilitation Creating illness weblog posts can be therapeutically beneficial for stroke survivors with aphasia as a tool that addresses psychological, emotional, and social aspects in their recovery. Blogging appeared to offer a medium for stroke survivors with aphasia to practice writing, to express ...
Source: Disability and Rehabilitation - August 31, 2020 Category: Rehabilitation Authors: Carcello K, McLennon S Tags: Disabil Rehabil Source Type: research