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Long-term outcomes of ischaemic stroke patients with diabetes in a multi-ethnic cohort in Singapore
CONCLUSION: Our study provides quantitative data on the event rates of ischaemic stroke patients with diabetes. These findings provide insights on stroke predictors in a multi-ethnic Asian population, which may have implications in the design of future interventional studies.PMID:33623954 | DOI:10.47102/annals-acadmedsg.2020105
Source: Ann Acad Med Singapo... - February 24, 2021 Category: General Medicine Authors: Ei Zune The Mei Yen Ng Geelyn JL Ng Bernadette GC Er Amy ML Quek Prakash Paliwal Leonard L Yeo Bernard Chan Vijay K Sharma Hock Luen Teoh Eric YH Khoo Raymond CS Seet Source Type: research

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia.
CONCLUSION: Our newly developed Malaysian IV rt-PA service is safe, with similar outcomes to the published literature. Functional outcome after thrombolysis was associated with baseline NIHSS scores and DM. PMID: 30488077 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - November 29, 2018 Category: General Medicine Authors: Tai MS, Goh KJ, Kadir KAA, Zakaria MI, Yap JF, Tan KS Tags: Singapore Med J Source Type: research

Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.
CONCLUSION: Eight biased TCM constitutions were closely related to specific diseases, and could be used to guide individualized prevention and treatment. More rigorously designed studies are recommended to further verify the constitution-disease relationship. PMID: 32744037 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - July 31, 2020 Category: Complementary Medicine Authors: Liang X, Wang Q, Jiang Z, Li Z, Zhang M, Yang P, Wang X, Wang Y, Qin Y, Li T, Zhang T, Wang Y, Sun J, Li Y, Luo H, Li L Tags: J Tradit Chin Med Source Type: research

IJERPH, Vol. 18, Pages 4406: Importance of Geospatial Heterogeneity in Chronic Disease Burden for Policy Planning in an Urban Setting Using a Case Study of Singapore
. Dickens Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated s...
Source: International Journal of Environmental Research and Public Health - April 21, 2021 Category: Environmental Health Authors: Ken Wei Tan Joel R. Koo Jue Tao Lim Alex R. Cook Borame L. Dickens Tags: Article Source Type: research

Factors Associated with Chronic Kidney Disease and Their Clinical Utility in Primary Care Clinics in a Multi-Ethnic Southeast Asian Population
Conclusions: CKD prevalence in our Southeast Asian population is high and under-documented even in high-risk patients. Our findings highlight factors associated with CKD, and the predictive value of hypertension, diabetes, and advancing age as EHR-based screening targets for CKD. Our results also suggest that complementary educational efforts will be needed to increase physician detection and optimize the management of CKD, especially in high risk and marginalized groups across all clinics in Singapore, and possibly in the region.Nephron
Source: Nephron - December 15, 2017 Category: Urology & Nephrology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia
Conclusion: Older adults with higher burden of CMVD, driven especially by diabetes, are likely to increase the risk of prevalent and incident MCI and dementia.Gerontology
Source: Gerontology - January 26, 2022 Category: Geriatrics Source Type: research

Death and cardiovascular outcomes in end-stage renal failure patients on different modalities of dialysis
CONCLUSION: The short-term incidence of death and AMI remains high in Singapore. Future studies should investigate the benefits of a tighter control of cardiovascular risk factors among ESRF patients on dialysis.PMID:35373236
Source: Ann Acad Med Singapo... - April 4, 2022 Category: General Medicine Authors: Chun Yuan Khoo Fei Gao Hui Lin Choong Wei Xian Alex Tan Riece Koniman Jiang Ming Fam Khung Keong Yeo Source Type: research

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