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Suboptimal lipid management before and after ischaemic stroke and TIA —the North Dublin Population Stroke Study
ConclusionsIn this population-based study, LLT recommended by international guidelines was under-used, before and after index stroke/TIA. Strategies to improve adherence are needed.
Source: Irish Journal of Medical Science - January 24, 2018 Category: General Medicine Source Type: research

Association of RAGE with acute ischemic stroke prognosis in type 2 diabetes
ConclusionAcute ischemic stroke is associated with elevated serum RAGE level, which, at admission, is an independent predictor of poor outcome for stroke in type 2 diabetes.
Source: Irish Journal of Medical Science - September 27, 2020 Category: General Medicine Source Type: research

Identifying patients with atrial fibrillation with a single CHA 2 DS 2 -VASC risk factor who are at higher risk of stroke
ConclusionPatients considered at low or intermediate risk using traditional risk stratification schemes, with  ≥ 2 points using this proposed low-risk index (65–74 years old, diabetics or a combination of chronic renal failure and an additional risk factor), had an overall stroke risk that may justify anticoagulation therapy.
Source: Irish Journal of Medical Science - April 12, 2021 Category: General Medicine Source Type: research

Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Orthopaedic and Trauma Surgery - December 17, 2022 Category: Orthopaedics Source Type: research

Peripheral Artery Disease: A Marked Lack of Awareness in Ireland.
CONCLUSIONS: This study demonstrates a disturbing lack of awareness of PAD and highlight the need for a meaningful targeted public health awareness campaign on PAD in order to close the gap of knowledge in Irish patients, prior to any prevention campaign. PMID: 25736513 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - February 28, 2015 Category: Surgery Authors: Cronin CT, McCartan DP, McMonagle M, Cross KS, Dowdall JF Tags: Eur J Vasc Endovasc Surg Source Type: research

Dietary patterns and retinal vessel caliber in the Irish Nun Eye Study
ConclusionIn this cohort of older women with a restricted lifestyle, an unhealthy DP was independently associated with an unfavorable retinal profile, namely a widening of retinal venules and narrowing of retinal arterioles. Key words: Dietary
Source: The Journal of Nutrition, Health and Aging - December 5, 2017 Category: Nutrition Source Type: research

A snapshot of type two diabetes mellitus management in general practice prior to the introduction of diabetes Cycle of Care
ConclusionsThis study provides a comprehensive snapshot of care in Irish general practice for patients with T2DM prior to the introduction of the Cycle of Care. Future research must investigate the impact of Cycle of Care on patient care in general practice.
Source: Irish Journal of Medical Science - February 7, 2018 Category: General Medicine Source Type: research

Obesity and cardiovascular risk in an oncology day ward population
ConclusionsWe observed similar or lower rates of obesity and CV risk factors in this cohort compared to the general adult Irish population. The average predicted risk of developing CV disease in this grp was moderate to high. This can have significant future implications with regard to cancer survivorship, disease recurrence and suitability for further oncological treatments.
Source: Irish Journal of Medical Science - December 18, 2018 Category: General Medicine Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Perceptions and attitudes toward risk and personal responsibility in the context of medical fitness to drive.
Conclusions: These results suggest that more needs to be done to raise awareness of the risks posed by medical and other factors that reduce driver capability and also about drivers' responsibility to ensure that they are fit to drive and thus improve road safety. PMID: 32421397 [PubMed - as supplied by publisher]
Source: Traffic Injury Prevention - May 17, 2020 Category: Accident Prevention Authors: Ryan M, Walshe J, Booth R, O'Neill DJ Tags: Traffic Inj Prev Source Type: research

Three-year clinical outcome of unprotected left main coronary artery disease patients complicated with chronic kidney disease treated by coronary artery bypass graft versus percutaneous coronary intervention
ConclusionCABG could be considered as the preferred treatment strategy compared with PCI with DES in ULMCAD patients complicated with CKD.
Source: Irish Journal of Medical Science - June 11, 2020 Category: General Medicine Source Type: research

Inclusion of medical fitness to drive in medical postgraduate training curricula.
CONCLUSION: There are notable deficits in MFTD training for specialists in Ireland and the UK. Common conditions which can significantly impair MFTD such as stroke, diabetes and alcohol use disorders are severely underrepresented and curricula should be revisited to include relevant training and guidance on MFTD for trainees. PMID: 32936112 [PubMed - as supplied by publisher]
Source: Journal of the Royal College of Physicians of Edinburgh - September 17, 2020 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

What to Know About Diabetes and the Risk of Silent Heart Attacks
At first it seemed like a routine call—something the paramedics had dealt with countless times before. A man in his mid-50s was having a heart attack, and his physician had called for emergency support. But when the paramedics arrived, the physician pulled them aside and told them something peculiar: the man had no cardiovascular symptoms whatsoever. The man had come to his doctor’s office because he’d woken early the previous morning sweating and with a sharp pain in his left wrist. These symptoms had quickly subsided and he’d gone back to sleep. Later, after going about his day, he’d visited...
Source: TIME: Health - November 4, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthscienceclimate heart health Source Type: news