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Total 173 results found since Jan 2013.

Long-term outcomes of mechanical versus biological valve prosthesis in native mitral valve infective endocarditis
Conclusion. The use of mechanical mitral valve prosthesis is associated with lower long-term mortality compared to the biological prosthesis in non-elder native mitral valve infective endocarditis patients. The routine choice of biological mitral valve prostheses for this patient group is not supported by the results.PMID:35652503 | DOI:10.1080/14017431.2022.2079712
Source: Scandinavian Cardiovascular Journal - June 2, 2022 Category: Cardiology Authors: Markus Malmberg Vesa Anttila P äivi Rautava Jarmo Gunn Ville Kyt ö Source Type: research

Association of income and educational levels with adherence to direct oral anticoagulant therapy in patients with incident atrial fibrillation: A Finnish nationwide cohort study
In conclusion, we observed that income and ed ucational levels both have independent positive association on the implementation of DOAC therapy but no association on therapy persistence in patients with AF.
Source: Pharmacology Research and Perspectives - May 23, 2022 Category: Drugs & Pharmacology Authors: Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Paula Tiili, Ossi Lehtonen, Mikko Niemi, Pirjo Mustonen, Janne Kinnunen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto Tags: ORIGINAL ARTICLE Source Type: research

242 Large vessel occlusion stroke in an emergency call: A descriptive analysis of emergency calls for thrombectomy candidates
ConclusionIn the emergency calls for patients with paramedic-suspected large vessel occlusion, typical stroke symptoms were described. The severity of the stroke stood out by the patients’ inability to speak any words or remain standing. It is possible to further develop stroke dispatch protocols to recognise thrombectomy candidates already during an emergency call.Conflict of interestNone.FundingNone.
Source: BMJ Open - May 1, 2022 Category: General Medicine Authors: Vuorinen, P., Kiili, J., Alanko, E., Huhtala, H., Ollikainen, J., Setälä, P., Hoppu, S. Tags: Open access Dispatch and triage Source Type: research

Trends in the Incidence and Risk Factors of Pregnancy-Associated Stroke
The objective of this review is to summarize studies on time trends of PAS in relation to trends in the prevalence of stroke risk factors in pregnant women. Seven retrospective national healthcare register-based cohort studies from the US, Canada, UK, Sweden, and Finland were identified. Five studies from the US, Canada, and Finland reported an increasing trend of PAS. Potential biases include more sensitive diagnostics and improved stroke awareness among pregnant women and professionals toward the end of the study period. However, the concurrent increase in the prevalence of several stroke risk factors among pregnant wome...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research

Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke
AbstractDuring the first hours after stroke onset, neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between the National Institutes of Health Stroke Scale (NIHSS) within 6  h of stroke onset and NIHSS at 24 h.A total of 5876 individuals from seven countries (Spain, Finland, Poland, USA, Costa Rica, Mexico and Korea) were studied using a multi-ancestry meta-analyses. We found tha...
Source: Brain - February 25, 2022 Category: Neurology Source Type: research

Compensated and non-compensated patient injury claims in internal carotid artery interventions in Finland, 2004-2017
CONCLUSION: Compensated patient injuries involving the treatment of ICAS are rare but often serious and mostly involve open surgery. Patient injury claims provide a valuable source of information for recognizing errors in care and offer possibilities to improve patient safety.PMID:35089091 | DOI:10.1177/17085381211069294
Source: Vascular - January 28, 2022 Category: Surgery Authors: Minna Laukkavirta Karin Blomgren Riitta Rautio Veikko Nikulainen P äivi Helmiö Source Type: research

Inflammatory Cytokines and Risk of Ischemic Stroke: A Mendelian Randomization Study
Conclusions: Our study suggested that genetically increased IL-4 levels showed a protective effect on the risk of ischemic stroke, which provides important new insights into the potential therapeutic target for preventing ischemic stroke.
Source: Frontiers in Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics
AbstractAtrial fibrillation (AF) is a major cause of ischemic stroke and the number of AF patients is increasing. Thus, up-to-date multifaceted data about the characteristics of AF patients, their treatments, and outcomes are urgently needed. The Finnish anticoagulation in atrial fibrillation (FinACAF) study has collected comprehensive data on all Finnish AF patients from 1st January 2004 to 31st December 2018. The aim of this paper is to describe the study rationale, the process of integrating data from the applied resources and to define the study cohort. Using national unique personal identification number, individual p...
Source: European Journal of Epidemiology - January 5, 2022 Category: Epidemiology Source Type: research

Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial-a randomized controlled trial
CONCLUSIONS: Vitamin D3 supplementation did not lower the incidence of major CVD events or invasive cancer among older adults, possibly due to sufficient vitamin D status in most participants at baseline. Clinical Trial Registry number: ClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813.PMID:34982819 | DOI:10.1093/ajcn/nqab419
Source: The American Journal of Clinical Nutrition - January 4, 2022 Category: Nutrition Authors: Jyrki K Virtanen Tarja Nurmi Antti Aro Elizabeth R Bertone-Johnson Elina Hypp önen Heikki Kr öger Christel Lamberg-Allardt JoAnn E Manson Jaakko Mursu Pekka M äntyselkä Sakari Suominen Matti Uusitupa Ari Voutilainen Tomi-Pekka Tuomainen Sari Hantunen Source Type: research