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Incretin-based therapy of metabolic disease
Dan Med J. 2022 Dec 21;70(1):A10220597.ABSTRACTRecent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment. Furthermore, the risk of dementia and cognitive impairment is reduced. A monomolecular coagonist (tirzepatide) of receptors for both incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) produced HbA1c values below 5.7% in 50% of the treated patients and weight losses exceeding 20% in obese individuals. These new...
Source: Danish Medical Journal - January 11, 2023 Category: General Medicine Authors: Jens Juul Holst Source Type: research