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Stroke Systems of Care during the COVID-19 Epidemic in Kobe City
The novel coronavirus disease 2019  (COVID-19), first reported in Wuhan, China, in December 2019, spread worldwide in 2020. As of June 1, 2020, the estimated number of global cases and deaths has exceeded 6 million and 370,000, respectively.1 In Japan, the number of reported cases increased sharply in March 2020, with community tran smission presenting at the highest rate in urban areas, leading to a state of emergency being declared by the Japanese government on April 7. Subsequently, on April 9, the Japan Stroke Society and the Japanese Circulation Society issued a joint statement on the importance of maintaining high-q...
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2020 Category: Neurology Authors: Nobuyuki Ohara, Hirotoshi Imamura, Hidemitsu Adachi, Yoshie Hara, Kohkichi Hosoda, Hidehito Kimura, Kazuyuki Kuwayama, Takashi Mizowaki, Yasuhiko Motooka, Kazuya Nakashima, Narihide Shinoda, Takeshi Takamoto, Yasushi Ueno, Ikuya Yamaura, Chie Yanagihara, Source Type: research

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.
Abstract The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a lim...
Source: Acta Pharmacologica Sinica - September 22, 2020 Category: Drugs & Pharmacology Authors: Zhang XL, Li ZM, Ye JT, Lu J, Ye LL, Zhang CX, Liu PQ, Duan DD Tags: Acta Pharmacol Sin Source Type: research

Comparison of Clinical Outcomes in Patients with ST Elevation Myocardial Infarction with Percutaneous Coronary Intervention and the Use of a Telemedicine App Before and After the COVID-19 Pandemic at a Center in Beijing, China, from August 2019 to March 2020.
CONCLUSIONS Telemedicine reduced the delay time of STEMI patients during the COVID-19 pandemic. The difference in short-term adverse clinical outcomes was not statistically significant between patients who used the app and those who did not. PMID: 32938901 [PubMed - in process]
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics of Acute Stroke in Patients with Coronavirus Disease 2019 and Challenges in Stroke Management during an Epidemic.
Abstract Coronavirus disease 2019 (COVID-19) is an ongoing pandemic infection associated with high morbidity and mortality. The Korean city of Daegu endured the first large COVID-19 outbreak outside of China. Since the report of the first confirmed case in Daegu on February 18, 2020, a total of 6,880 patients have been reported until May 29, 2020. We experienced five patients with ischemic stroke and COVID-19 during this period in four tertiary hospitals in Daegu. The D-dimer levels were high in all three patients in whom D-dimer blood testing was performed. Multiple embolic infarctions were observed in three pati...
Source: J Korean Med Sci - September 6, 2020 Category: General Medicine Authors: Kwon DH, Do Y, Eun MY, Lee J, Park H, Sohn SI, Hong JH Tags: J Korean Med Sci Source Type: research

Coagulopathy and thromboembolic events in patients with SARS-CoV-2 infection: pathogenesis and management strategies
AbstractIn October 2019, a viral infectious disease appeared in the city of Wuhan in China. A new betacoronavirus, SARS-CoV-2, has been recognized as the responsible pathogen in this infection. Although coronavirus disease is principally expressed as a pulmonary infection, critical SARS-CoV-2 infection is frequently complicated with coagulopathy, and thromboembolic events are recognizable in several patients. Dehydration, acute inflammatory condition, protracted immobilization during disease, existence of multiple cardiovascular risk factors such as diabetes, obesity or hypertension, previous coronary artery disease, ische...
Source: Annals of Hematology - August 13, 2020 Category: Hematology Source Type: research

Cerebrovascular Disease in COVID-19 ADULT BRAIN
We report a case of COVID-19 with acute ischemic stroke. To our knowledge, this is the first reported case of COVID-19-related cerebral infarcts that includes brain imaging at multiple time points and CT angiography. There is a growing body of published evidence that complications of COVID-19 are not limited to the pulmonary system. Neuroradiologists should be aware of a wide range of neurologic manifestations, including cerebrovascular disease.
Source: American Journal of Neuroradiology - July 12, 2020 Category: Radiology Authors: Goldberg, M. F., Goldberg, M. F., Cerejo, R., Tayal, A. H. Tags: ADULT BRAIN Source Type: research

Spectrum of Neurological Manifestations in Covid-19: A Review
Ravindra K GargNeurology India 2020 68(3):560-572 COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. In COVID-19, both central and peripheral nervous systems can be affected. The SARS-CoV-2 virus causes the disease COVID-19 and has the potential to invade the brain. The SARS-CoV-2 virus enters the brain either via a hematogenous route or olfactory system. A...
Source: Neurology India - July 5, 2020 Category: Neurology Authors: Ravindra K Garg Source Type: research

Coronaviruses and Central Nervous System Manifestations
SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not expl...
Source: Frontiers in Neurology - June 22, 2020 Category: Neurology Source Type: research

Neurological involvement of coronavirus disease 2019: a systematic review
ConclusionsNeurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain –Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurol ogical diagnoses that can mimic COVID-19 during the pandemic.
Source: Journal of Neurology - June 18, 2020 Category: Neurology Source Type: research

COVID 19 – Conspiracy or Apocalypse? – Part II
By Daud Khan and Leila Yasmine KhanAMSTERDAM/ROME, Jun 8 2020 (IPS) As the COVID-19 virus spread rapidly around the globe, so did various theories about what caused the pandemic. According to the standard scientific theory, the virus originated in bats; crossed over to humans, probably via another intermediate host; and then spread rapidly across the globe. While the mainstream scientific theory sufficed for some, a large number of people saw the pandemic as the work of cold-hearted military or industrial strategists. An equally large number of people saw it as some kind of divine or natural retribution for an increasingly...
Source: IPS Inter Press Service - Health - June 8, 2020 Category: International Medicine & Public Health Authors: Daud Khan and Leila Yasmine Khan Tags: Global Headlines Health TerraViva United Nations Coronavirus Source Type: news

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
Abstract 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Recently, Mao et al. [1] investigated the penetration potential of SARS-CoV-2 into the central nervous system in 214 patients. They reported that 36.4% of the patients had some neurologic findings which are ranged from nonsp...
Source: Current Neurovascular Research - May 21, 2020 Category: Neurology Authors: Bostanciklioglu M, Temiz E Tags: Curr Neurovasc Res Source Type: research

Unusual Symptoms of Coronavirus: What We Know So Far
While most people are familiar with the hallmark symptoms of COVID-19 by now—cough, fever, muscle aches, headaches and difficulty breathing—a new crop of medical conditions are emerging from the more than 4 million confirmed cases of the disease around the world. These include skin rashes, diarrhea, kidney abnormalities and potentially life-threatening blood clots. It’s not unusual for viruses to directly infect and affect different tissues and organs in the body, but it is a bit unusual for a primarily respiratory virus like SARS-CoV-2, which is responsible for COVID-19, to have such a wide-ranging reach...
Source: TIME: Health - May 19, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Falling stroke rates during COVID-19 pandemic at a comprehensive stroke center
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Falling stroke rates during COVID-19 pandemic at a Comprehensive Stroke Center: Cover title: Falling stroke rates during COVID-19
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights
An outbreak of an acute respiratory illness of unknown cause started in Wuhan, Hubei province, China on December 12, 2019.1,2 A new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in these patients. Subsequently, the identified acute respiratory illness was named coronavirus disease 2019 (COVID-19). Soon thereafter, the COVID-19 epidemic in China became a pandemic with a significant burden on healthcare and the world-wide economy. SARS-CoV-2 has been shown to be a distinct class of the beta coronaviruses (Beta-CoVs) with a 79.5% gene sequence homology to the severe ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2020 Category: Neurology Authors: Afshin A. Divani, Sasan Andalib, Mario Di Napoli, Simona Lattanzi, M. Shazam Hussain, Jos é Biller, Louise D. McCullough, M. Reza Azarpazhooh, Alina Seletska, Stephan A. Mayer, Michel Torbey Tags: Review Article Source Type: research

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