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Total 2601 results found since Jan 2013.

Changes in ischemic stroke presentations, management and outcomes during the first year of the COVID-19 pandemic in Alberta: a population study
CMAJ. 2022 Mar 28;194(12):E444-E455. doi: 10.1503/cmaj.211003.ABSTRACTBACKGROUND: Pandemics may promote hospital avoidance, and added precautions may exacerbate treatment delays for medical emergencies such as stroke. We sought to evaluate ischemic stroke presentations, management and outcomes during the first year of the COVID-19 pandemic.METHODS: We conducted a population-based study, using linked administrative and stroke registry data from Alberta to identify all patients presenting with stroke before the pandemic (Jan. 1, 2016 to Feb. 27, 2020) and in 5 periods over the first pandemic year (Feb. 28, 2020 to Mar. 31, 2...
Source: Canadian Medical Association Journal - March 29, 2022 Category: General Medicine Authors: Aravind Ganesh Jillian M Stang Finlay A McAlister Oleksandr Shlakhter Jessalyn K Holodinsky Balraj Mann Michael D Hill Eric E Smith Source Type: research

The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion.
Abstract Exercise preconditioning has been shown to be effective in improving behavioral and neuropathological indices after cerebral ischemia. We evaluated the effect of exercise preconditioning, 17β-estradiol, and their combination on stroke outcome using an experimental model of stroke in ovariectomized (OVX) mice. OVX mice were randomly assigned to four groups as follows: control (stroke), exercise (exercise and stroke), estradiol (17β-estradiol and stroke), and exercise+estradiol (exercise and 17β-estradiol and stroke). Exercise preconditioning was performed on a treadmill five days per week, 40 min/day, a...
Source: Canadian Journal of Physiology and Pharmacology - September 5, 2017 Category: Drugs & Pharmacology Authors: Naderi S, Alimohammadi R, Hakimizadeh E, Roohbakhsh A, Shamsizadeh A, Allahtavakoli M Tags: Can J Physiol Pharmacol Source Type: research

Secondary prevention treatment after acute stroke in older South Asian, Chinese and other Canadians: a retrospective data analysis.
Abstract BACKGROUND: Little is known about whether there are differences in medication use between older patients of Chinese descent, those of South Asian descent and other Canadian patients after acute ischemic or primary intracerebral hemorrhagic stroke. The aim of this population-based study was to evaluate potential ethnic differences in secondary prevention pharmacotherapy after acute stroke. METHODS: Using health administrative data, we conducted a retrospective analysis of all patients aged 66 years or more admitted to hospital with acute stroke in Ontario (1997-2011) and British Columbia (1997-2009). ...
Source: cmaj - September 11, 2017 Category: General Medicine Authors: Khan NA, McAlister FA, Pilote L, Palepu A, Quan H, Hill MD, Fang J, Kapral MK Tags: CMAJ Open Source Type: research

Timely access to inpatient rehabilitation after stroke: a qualitative study of perceived barriers and potential solutions in Ontario, Canada.
CONCLUSIONS: The structure of Ontario's health care system presents challenges to early transfer of stroke patients to inpatient rehabilitation, yet the stakeholders consulted in this study felt that these could be addressed with proper planning, improved coordination and targeted investment. Implications for rehabilitation Stroke units are a well-established best practice in stroke care and timely access to rehabilitation is a key component of their effectiveness. Stroke experts in Ontario, Canada recommend transfer of suitable patients to inpatient rehabilitation on day 5 and day 7, on average, after ischemic and hemorrh...
Source: Disability and Rehabilitation - September 18, 2017 Category: Rehabilitation Authors: Meyer MJ, Teasell R, Kelloway L, Meyer SB, Willems D, O'Callaghan C Tags: Disabil Rehabil Source Type: research

Elevated Incidence of Atrial Fibrillation and Stroke in Patients with Atrial Flutter – A Population-Based Study
Conclusions Patients with isolated atrial flutter develop atrial fibrillation and stroke at a higher rate than the general population. Catheter ablation reduces but does not eliminate future AF incidence and stroke risk and continued anticoagulation after successful atrial flutter ablation may therefore be warranted. Teaser We examine the incidence of atrial fibrillation and stroke in a large real-world cohort of patients with atrial flutter, and the impact of atrial flutter ablation. Patients with atrial flutter developed atrial fibrillation and stroke at a higher rate than the general population. Atrial flutter ablation ...
Source: Canadian Journal of Cardiology - January 6, 2018 Category: Cardiology Source Type: research

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial
This report presents a secondary analysis, and follow-up is complete. Findings Between May, 2001, and October, 2008, 1713 patients were enrolled and randomly allocated treatment (855 were assigned stenting and 858 endarterectomy), of whom 1530 individuals were followed up with ultrasound (737 assigned stenting and 793 endarterectomy) for a median of 4·0 years (IQR 2·3–5·0). At least moderate restenosis (≥50%) occurred in 274 patients after stenting (cumulative 5-year risk 40·7%) and in 217 after endarterectomy (29·6%; unadjusted hazard ratio [HR] 1·43, 95% CI 1·21–1·72; p<0·0001). Patients with at lea...
Source: The Lancet Neurology - June 1, 2018 Category: Neurology Source Type: research

Integrating Individuals with Stroke into Cardiac Rehabilitation Following Traditional Stroke Rehabilitation: Promoting a Continuum of Care
Publication date: Available online 11 July 2018Source: Canadian Journal of CardiologyAuthor(s): Susan Marzolini, R. KinUnstructured AbstractIndividuals following stroke are at a high risk for a repeat stroke and for complications related to coronary artery disease. Indeed, stroke and coronary artery disease share many of the same risk factors. Unfortunately, patients become sedentary after stroke leading to cardiorespiratory deconditioning as well as muscle atrophy and weakness that leads to deterioration in metabolic, cardiorespiratory, and functional health. Access to intensive secondary prevention programs with a struct...
Source: Canadian Journal of Cardiology - July 12, 2018 Category: Cardiology Source Type: research

Intention to Return to Work after Stroke Following Rehabilitation in Ontario.
This study examined the prevalence of intention to return to work after discharge among stroke rehabilitation inpatients. METHODS.: We performed secondary analysis of National Rehabilitation Reporting System data for all stroke rehabilitation inpatients across Ontario (2012-2017). Intention to return to work was examined by gender, age, and level of disability. FINDINGS.: Among 25,691 stroke rehabilitation inpatients, 4,668 (18.2%) were employed pre-stroke and 2,039 (43.7%) of them intended to return to work. Intention to return to work was somewhat higher among younger and middle-aged stroke survivors and those ...
Source: Canadian Journal of Occupational Therapy - February 12, 2020 Category: Occupational Health Authors: Duong PK, Egan MY, Meyer MJ, Morrison TL Tags: Can J Occup Ther Source Type: research

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Perioperative stroke and myocardial infarction in urologic surgery
CONCLUSIONS: Perioperative stroke and myocardial infarction were confirmed to be uncommon but devastating complications of urologic surgery, with incidence of 0.14% and 0.36%, respectively. Cystectomy was the highest risk urologic procedure. Perioperative stroke and myocardial infarction were strongly associated with age ≥ 70, hypertension, and disseminated cancer.PMID:34129461
Source: Canadian Journal of Urology - June 15, 2021 Category: Urology & Nephrology Authors: Da David Jiang Kyle A Gillis Yiyi Chen Jason C Hedges Nicholas H Chakiryan Source Type: research