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Condition: Disability
Nutrition: Iron
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Total 24 results found since Jan 2013.
Regulation of the p53 ‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
Exp Ther Med. 2023 Jan 26;25(3):113. doi: 10.3892/etm.2023.11812. eCollection 2023 Mar.ABSTRACTStroke is one of the most threatening diseases worldwide, particularly in countries with larger populations; it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel ruptures) or ischemic stroke (blockage of an artery). Whilst the incidence of stroke is higher in the elderly population (≥65), it is also increasing in the younger population. Ischemic stroke accounts for ~85% of a...
Source: Experimental and Therapeutic Medicine - February 16, 2023 Category: General Medicine Authors: Shuangli Xu Xuewei Li Yanqiang Wang Source Type: research
Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
In conclusion, the mutual regulation of autophagy and inflammation in ICH is worth exploring. The control of inflammation by autophagy will hopefully prove to be an essential treatment target for ICH.PMID:36726453 | PMC:PMC9884704 | DOI:10.3389/fncel.2022.1036313
Source: Cancer Control - February 2, 2023 Category: Cancer & Oncology Authors: Kaijing Fu Weilin Xu Cameron Lenahan Yong Mo Jing Wen Teng Deng Qianrong Huang Fangzhou Guo Ligen Mo Jun Yan Source Type: research
TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3 β signaling pathway
In conclusion, Fer-1 has protective effects on cerebral I/R injury by activating the AKT/GSK3β pathway, indicating that ferroptosis may become a novel target in the treatment of ischemic stroke.PMID:36596364 | DOI:10.1016/j.brainresbull.2022.12.009
Source: Brain Research - January 3, 2023 Category: Neurology Authors: Xinyao Liu Yue Du Jian Liu Linggang Cheng Wen He Wei Zhang Source Type: research
Ferroptosis —A Novel Mechanism With Multifaceted Actions on Stroke
As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship betwe...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research
Bibliometric Analysis of Ferroptosis in Stroke From 2013 to 2021
Conclusion: Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic “ferroptosis in stroke”, to produce more exciting results and provide new insights into the bottleneck of stroke treatment.
Source: Frontiers in Pharmacology - February 21, 2022 Category: Drugs & Pharmacology Source Type: research
Role of Ferroptosis in Stroke
Cell Mol Neurobiol. 2022 Jan 31. doi: 10.1007/s10571-022-01196-6. Online ahead of print.ABSTRACTStroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on. According to different causes, stroke can be generally divided into hemorrhagic stroke and ischemic stroke, whose pathogenesis and treatment are quite different. Ferroptosis is a new type of cell death first def...
Source: Cellular and Molecular Neurobiology - February 1, 2022 Category: Cytology Authors: Yunfei Xu Kexin Li Yao Zhao Lin Zhou Ying Liu Jie Zhao Source Type: research
Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis, characterized by lethal aggregation of lipid peroxidation. However, a paucit...
Source: BMC Genomics - January 16, 2022 Category: Genetics & Stem Cells Authors: Jiaxin Fan, Mengying Chen, Shuai Cao, Qingling Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Yizhou Huang, Nan Zhang, Kaili Shi and Shuqin Zhan Tags: Research Source Type: research
Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study
AbstractStroke is the third leading cause of death in the United States and the leading cause of adult disability. Despite enormous research efforts including many clinical trials, tissue plasminogen activator (tPA) remains the only FDA-approved treatment for acute ischemic stroke. Unfortunately, only 1 –3% of stroke patients in the US receive this therapy because of the narrow time window and severe side effects for using tPA. The most deadly and damaging side effect is the risk of intracranial bleeding or hemorrhage. For that reason, the dose of tPA and its overall administration are under tigh t control, which may com...
Source: Journal of Thrombosis and Thrombolysis - November 10, 2021 Category: Hematology Source Type: research
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
Pharmacol Res. 2021 Oct 8:105933. doi: 10.1016/j.phrs.2021.105933. Online ahead of print.ABSTRACTIschemic stroke poses a significant health risk due to its high rate of disability and mortality. To address this problem, several therapeutic approaches have been proposed, including interruption targeting programmed cell death (PCD). Ferroptosis is a newly defined PCD characterized by iron-dependent accumulation of lipid peroxidation, and is becoming a promising target for treating numerous diseases. To explore the underlying mechanisms of the initiation and execution of ferroptosis in ischemic stroke, we established stroke m...
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Chong Li Guangchi Sun Binglin Chen Lei Xu Yangfan Ye Jinyan He Zhongyuan Bao Pengzhan Zhao Zong Miao Lin Zhao Jingming Hu Yongping You Ning Liu Honglu Chao Jing Ji Source Type: research
