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Specialty: Biomedical Science
Condition: Thrombosis

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Total 134 results found since Jan 2013.

Validation of two severity scores as predictors for outcome in Coronavirus Disease 2019 (COVID-19)
by Christian Salbach, Matthias Mueller-Hennessen, Moritz Biener, Kiril M. Stoyanov, Mehrshad Vafaie, Michael R. Preusch, Lars P. Kihm, Uta Merle, Paul Schnitzler, Hugo A. Katus, Evangelos Giannitsis BackgroundAn established objective and standardized reporting of clinical severity and disease progression in COVID-19 is still not established. We validated and compared the usefulness of two classification systems reported earlier –a severity grading proposed by Siddiqi and a system from the National Australian COVID-19 guideline. Both had not been validated externally and were now tested for their ability to predict compli...
Source: PLoS One - February 19, 2021 Category: Biomedical Science Authors: Christian Salbach Source Type: research

A novel risk model to predict first-ever ischemic stroke in heart failure with reduced ejection fraction.
Abstract Patients with heart failure are at increased risk for ischemic stroke. We aim to develop a more accurate stroke risk prediction tools identify high-risk patients with heart failure with reduced ejection fraction (HFrEF). Patient data were extracted retrospectively from the electronic medical database between January 2009 and February 2019. Univariate and multivariate Cox regression analysis were performed to identify independent predictors, which were utilized to construct a nomogram for predicting ischemic stroke. AUROC analysis was used to compare the prognostic value between the new risk score and CHAD...
Source: Aging - February 1, 2021 Category: Biomedical Science Authors: Zhou X, Yu L, Hu W, Shi R, Ji Y, Zhou C, Xue C, Yu G, Huang W, Shan P Tags: Aging (Albany NY) Source Type: research

Thromboembolism in Patients with Hypertrophic Cardiomyopathy.
Authors: Liu L, Liu Z, Chen X, He S Abstract Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive m...
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Computational investigation of blood flow and flow-mediated transport in arterial thrombus neighborhood.
Abstract A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation-based...
Source: Biomechanics and Modeling in Mechanobiology - January 12, 2021 Category: Biomedical Science Authors: Teeraratkul C, Irwin Z, Shadden SC, Mukherjee D Tags: Biomech Model Mechanobiol Source Type: research

BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation
Store-operated Ca2+ entry (SOCE) is the major route of Ca2+ influx in platelets. The Ca2+ sensor stromal interaction molecule 1 (STIM1) triggers SOCE by forming punctate structures with the Ca2+ channel Orai1 and the inositol trisphosphate receptor (IP3R), thereby linking the endo-/sarcoplasmic reticulum to the plasma membrane. Here, we identified the BAR domain superfamily member bridging integrator 2 (BIN2) as an interaction partner of STIM1 and IP3R in platelets. Deletion of platelet BIN2 (Bin2fl/fl,Pf4-Cre mice) resulted in reduced Ca2+ store release and Ca2+ influx in response to all tested platelet agonists. These de...
Source: Journal of Clinical Investigation - October 13, 2020 Category: Biomedical Science Authors: Julia Volz, Charly Kusch, Sarah Beck, Michael Popp, Timo Vögtle, Mara Meub, Inga Scheller, Hannah S. Heil, Julia Preu, Michael K. Schuhmann, Katherina Hemmen, Thomas Premsler, Albert Sickmann, Katrin G. Heinze, David Stegner, Guido Stoll, Attila Braun, M Source Type: research

Research Articles Disrupting the platelet internal membrane via PI3KC2{alpha} inhibition impairs thrombosis independently of canonical platelet activation
Arterial thrombosis causes heart attacks and most strokes and is the most common cause of death in the world. Platelets are the cells that form arterial thrombi, and antiplatelet drugs are the mainstay of heart attack and stroke prevention. Yet, current drugs have limited efficacy, preventing fewer than 25% of lethal cardiovascular events without clinically relevant effects on bleeding. The key limitation on the ability of all current drugs to impair thrombosis without causing bleeding is that they block global platelet activation, thereby indiscriminately preventing platelet function in hemostasis and thrombosis. Here, we...
Source: Science Translational Medicine - July 21, 2020 Category: Biomedical Science Authors: Selvadurai, M. V., Moon, M. J., Mountford, S. J., Ma, X., Zheng, Z., Jennings, I. G., Setiabakti, N. M., Iman, R. P., Brazilek, R. J., Z. Abidin, N. A., Chicanne, G., Severin, S., Nicholls, A. J., Wong, C. H. Y., Rinckel, J.-Y., Eckly, A., Gachet, C., Nes Tags: Research Articles Source Type: research

Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis.
This study evaluated the benefit of dual therapy in reducing ischemic events in atrial fibrillation (AF) patients presenting with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) comparing dual and triple therapies (oral anticoagulation plus aspirin and P2Y12 inhibitor) for AF patients with ACS or those undergoing PCI. The composite primary outcome included all-cause death, myocardial infarction (MI), stent thrombosis (ST), or stroke. Relative risk (RR) and the corresponding 95% confiden...
Source: Aging - June 30, 2020 Category: Biomedical Science Authors: Guo W, Chen X, Hao Y, Liu Q, Peng C, Zhao L, Feng Z, Wang X, Ruan H, Li L Tags: Aging (Albany NY) Source Type: research

Activated α < sub > IIb < /sub > β < sub > 3 < /sub > on platelets mediates flow-dependent NETosis via SLC44A2
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand factor/glycoprotein Iba-dependent platelet 'priming' induces integrin aIIbb3 activation that, in turn, mediates neutrophil and T-cell binding. Binding of platelet aIIbb3 to SLC44A2 on neutrophils leads to mechanosensitive-dependent production of highly prothrombotic neutrophil extracellular traps. A polymorphism inSLC44A2 (rs2288904-A) present in 22% of the population causes an R154Q substitution in an extracell...
Source: eLife - April 21, 2020 Category: Biomedical Science Tags: Cell Biology Human Biology and Medicine Source Type: research

Association of DIAPH1 gene polymorphisms with ischemic stroke.
Abstract DIAPH1 is a formin protein involved in actin polymerization with important roles in vascular remodeling and thrombosis. To investigate potential associations of DIAPH1 single-nucleotide polymorphisms (SNPs) with hypertension and stroke, 2,012 patients with hypertension and 2,210 controls, 2,966 stroke cases [2,212 ischemic stroke (IS), 754 hemorrhagic stroke (HS)] and 2,590 controls were enrolled respectively in the case-control study. A total of 4,098 individual were included in the cohort study. DIAPH1 mRNA expression was compared between 66 IS [43 small artery occlusion (SAO) and 23 large-artery athero...
Source: Aging - January 2, 2020 Category: Biomedical Science Authors: Ren Z, Chen X, Tang W, Li J, Yang S, Chen Y, Zhao X, Zong H, Liu C, Shen C Tags: Aging (Albany NY) Source Type: research

Caveolin-1 and MLRs: A potential target for neuronal growth and neuroplasticity after ischemic stroke.
Authors: Zhong W, Huang Q, Zeng L, Hu Z, Tang X Abstract Ischemic stroke is a leading cause of morbidity and mortality worldwide. Thrombolytic therapy, the only established treatment to reduce the neurological deficits caused by ischemic stroke, is limited by time window and potential complications. Therefore, it is necessary to develop new therapeutic strategies to improve neuronal growth and neurological function following ischemic stroke. Membrane lipid rafts (MLRs) are crucial structures for neuron survival and growth signaling pathways. Caveolin-1 (Cav-1), the main scaffold protein present in MLRs, targets man...
Source: International Journal of Medical Sciences - November 2, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Independent ischemic stroke risk factors in older Americans: a systematic review.
Abstract The Framingham Stroke Risk Profile (FSRP) is a validated model for predicting 10-year ischemic stroke risk in middle-aged adults, yet has not been demonstrated to consistently translate in older populations. This is a systematic review of independent risk factors measured among > 65 year olds, with subsequent first ischemic stroke, using PRISMA guidelines. We appraised peer-reviewed publications that included participants > 65 years old at risk assessment. Combined with other criteria, results were abstracted from 28 papers reporting six types of stroke risk factors: Serologic/Diagnostic, Convention...
Source: Aging - May 23, 2019 Category: Biomedical Science Authors: Singer J, Gustafson D, Cummings C, Egelko A, Mlabasati J, Conigliaro A, Levine SR Tags: Aging (Albany NY) Source Type: research

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. Here, we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing link. Using a humanized knockin (KI) mouse model and in vitro organotypic cultures, we found that reoxygenation or calcium overload increased brain ROS levels in a NOX5-dependent manner. In vivo, postischemic ROS formation, in...
Source: Journal of Clinical Investigation - March 19, 2019 Category: Biomedical Science Authors: Ana I. Casas, Pamela W.M. Kleikers, Eva Geuss, Friederike Langhauser, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Martin Hrabê de Angelis, Javier Egea, Manuela G. Lopez, Christoph Kleinschnitz, Harald H.H.W. Schmidt Source Type: research

Research Articles Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models
Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platelet activation cascades. Here, we describe the development of detergent-extracted human modified platelets (platelet decoys) that retained platelet binding functions but were incapable of functional activation and aggregation. Platelet decoys inhibited aggregation and adhesion of platelets on thrombogenic surfa...
Source: Science Translational Medicine - February 13, 2019 Category: Biomedical Science Authors: Papa, A.-L., Jiang, A., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., Nash, E., Caroff, J., Graveline, A., Vernet, A., Mammoto, A., Mammoto, T., Jain, A., Kamm, R. D., Gounis, M. J., Ingber, D. E. Tags: Research Articles Source Type: research

Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II.
Conclusion: INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction. PMID: 30505257 [PubMed - in process]
Source: Journal of Korean Medical Science - December 8, 2018 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Safety of early discharge in low risk patients after acute ST-segment elevation myocardial infarction, treated with primary percutaneous coronary intervention. Open label, randomized trial.
CONCLUSION: This study confirms that early discharge within 48-72 h in selected low risk patients after STEMI treated with successful primary PCI is feasible and safe, with outcomes comparable to the later discharge. This strategy applies to more than a quarter of all STEMI patients. PMID: 30181666 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 6, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research