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Specialty: Biomedical Science
Condition: Thrombosis
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Total 134 results found since Jan 2013.
Sociodemographic disparities in concomitant left atrial appendage occlusion during cardiac valve operations
by Ayesha P. Ng, Nikhil Chervu, Yas Sanaiha, Amulya Vadlakonda, Elsa Kronen, Peyman Benharash
BackgroundSociodemographic disparities in atrial fibrillation (AF) management and thromboembolic prophylaxis have previously been reported, which may involve inequitable access to left atrial appendage occlusion (LAAO) during cardiac surgery. The present study aimed to evaluate the association of LAAO utilization with sex, race, and hospital region among patients with AF undergoing heart valve operations. MethodsAdults with AF undergoing valve replacement/repair in the 2012 –2019 National Inpatient Sample were identified and str...
Source: PLoS One - May 25, 2023 Category: Biomedical Science Authors: Ayesha P. Ng Source Type: research
Safe and effective thrombolysis in free flap salvage: Intra-arterial urokinase infusion
by Jun Hyeok Kim, Sungyeon Yoon, Heeyeon Kwon, Deuk Young Oh, Young-Joon Jun, Suk-Ho Moon
Despite the high success rate in reconstruction using free tissue transfer, flap failure is often caused by microvascular thrombosis. In a small percentage of cases with complete flap loss, a salvage procedure is performed. In the present study, the effectiveness of intra-arterial urokinase infusi on through the free flap tissue was investigated to develop a protocol to prevent thrombotic failure. The retrospective study evaluated the medical records of patients who underwent salvage procedure with intra-arterial urokinase infusion a...
Source: PLoS One - March 13, 2023 Category: Biomedical Science Authors: Jun Hyeok Kim Source Type: research
Venous thromboembolism: Why is it still a significant health problem?
CONCLUSIONS: Understanding the interaction between environmental and genetic factors appears to be crucial in the diagnostic process. It can provide insight into the pathophysiology of VTE, potentially identifying options for targeted prevention and treatment. However, due to differences in clinical presentation, diagnosing pulmonary embolism may not be an easy task which perfectly illustrates the scale and complexity of the disease.PMID:36368288 | DOI:10.1016/j.advms.2022.10.002
Source: Advances in Medical Sciences - November 11, 2022 Category: Biomedical Science Authors: Monika Oleksiuk-B ójko Anna Lisowska Source Type: research
Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke
ConclusionsWe found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF- α at admission were associated with post-thrombolytic ENI in stroke. The role of biomarkers warrants further investigation. Trial registrationClinical Trial Registration: https://www.clinicaltrials.gov; identifier: NCT02854592.
Source: PLoS One - October 31, 2022 Category: Biomedical Science Authors: Yu Cui Source Type: research
A high sucrose diet modifies brain oxylipins in a sex-dependent manner
Oxylipins are oxidation products of polyunsaturated fatty acids (PUFAs), produced through the action of cyclooxygenase (COX), lipoxygenase (LOX), cytochrome p450 (CYP), and non-enzymatic oxidation pathways [1]. Oxylipins can be esterified or free, with free oxylipins presumed to be the biologically active form [1]. Although the study of oxylipins and their functions is relatively new, there is evidence of their involvement in thrombosis, inflammation, the development of diabetes, the progression of cardiovascular diseases, and stroke [2 –7].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 7, 2022 Category: Biomedical Science Authors: Jennifer E. Norman, Saivageethi Nuthikattu, Dragan Milenkovic, John C. Rutledge, Amparo C. Villablanca Tags: Original research article Source Type: research
Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse
Front Biosci (Schol Ed). 2022 Jul 21;14(3):21. doi: 10.31083/j.fbs1403021.ABSTRACTThe most frequent arrhythmia treated is atrial fibrillation (AF), which necessitates the use of oral anticoagulants (OACs) to reduce the risk of thromboembolism and stroke. Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease (ESKD). On the other hand, direct OACs (DOACs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close inte...
Source: Frontiers in Bioscience - Scholar - September 22, 2022 Category: Biomedical Science Authors: Nikolaos Ktenopoulos Marios Sagris Panagiotis Theofilis Sophia Lionaki Loukianos S Rallidis Source Type: research
