• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Clinical-CT mismatch defined NIHSS ≥ 8 and CT-ASPECTS ≥ 9 as a reliable marker of candidacy for intravenous thrombolytic therapy in acute ischemic stroke
by Hung-Ming Wu, I-Hui Lee, Chao-Bao Luo, Chih-Ping Chung, Yung-Yang Lin BackgroundClinical-diffusion mismatch between stroke severity and diffusion-weighted imaging lesion volume seems to identify stroke patients with penumbra. However, urgent magnetic resonance imaging is sometimes inaccessible or contraindicated. Thus, we hypothesized that using brain computed tomography (CT) to determine a baseline “clinical-CT mismatch” may also predict the responses to thrombolytic therapy. MethodsBrain CT lesions were measured using the Alberta Stroke Program Early CT Score (ASPECTS). A total of 104 patients were included: 79 pa...
Source: PLoS One - April 30, 2021 Category: Biomedical Science Authors: Hung-Ming Wu Source Type: research

Long-term Outcomes of Clopidogrel Monotherapy versus Prolonged Dual Antiplatelet Therapy beyond 12 Months after Percutaneous Coronary Intervention in High-risk Patients
CONCLUSION: Compared with prolonged DAPT, clopidogrel monotherapy showed similar long-term outcomes in patients at high-risk after second-generation DES implantation.PMID:33904262 | DOI:10.3346/jkms.2021.36.e106
Source: Journal of Korean Medical Science - April 27, 2021 Category: Biomedical Science Authors: Dong Yeon Kim Sung Woo Cho Kyu Tae Park Jong Hwa Ahn Taek Kyu Park Yong Ho Jang Ki Hong Choi Joo Myung Lee Jeong Hoon Yang Young Bin Song Jin Ho Choi Seung Hyuk Choi Hyeon Cheol Gwon Sang Hoon Lee Joo Yong Hahn Source Type: research

Sensitive LC-MS/MS method for quantification of Rivaroxaban in plasma: application to pharmacokinetic studies
Biomed Chromatogr. 2021 Apr 22:e5147. doi: 10.1002/bmc.5147. Online ahead of print.ABSTRACTRivaroxaban is an anticoagulant (orally active direct Xa inhibitor) indicated to reduce the risk of stroke and systemic embolism, for treatment and prophylaxis of deep vein thrombosis, for treatment of pulmonary embolism, as well as other cardiovascular complications. Bioanalytical methods for rivaroxaban quantification in plasma are necessary for application in pharmacokinetic studies, as well as in drug therapeutic monitoring. This work developed and validated a sensitive bioanalytical method by LC-MS/MS for rivaroxaban quantificat...
Source: Biomedical Chromatography : BMC - April 22, 2021 Category: Biomedical Science Authors: Alexandre Cavenatti de Oliveira Marcelo Gomes Davan ço Daniel Rossi de Campos Pedro Henrique Godoy Sanches Jo ão Pedro Gonçalves Cirino Patricia de Oliveira Carvalho Marcia Aparecida Ant ônio Edvaldo Capobiango Coelho Andreia de Melo Porcari Source Type: research

Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study
ConclusionsIn Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation, rivaroxaban may be associated with a similar risk of major bleeding but a lower risk of thromboembolism compared with warfarin. The potential benefit of 10 mg of rivaroxaban in this population requires further investigation.
Source: PLoS One - April 8, 2021 Category: Biomedical Science Authors: Yi-Cheng Lin Source Type: research

Research Articles Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke
Neuroprotection for acute ischemic stroke is achievable with the eicosapeptide nerinetide, an inhibitor of the protein-protein interactions of the synaptic scaffolding protein PSD-95. However, nerinetide is subject to proteolytic cleavage if administered after alteplase, a standard-of-care thrombolytic agent that nullifies nerinetide’s beneficial effects. Here, we showed, on the basis of pharmacokinetic data consistent between rats, primates, and humans, that in a rat model of embolic middle cerebral artery occlusion (eMCAO), nerinetide maintained its effectiveness when administered before alteplase. Because of its s...
Source: Science Translational Medicine - April 7, 2021 Category: Biomedical Science Authors: Mayor-Nunez, D., Ji, Z., Sun, X., Teves, L., Garman, J. D., Tymianski, M. Tags: Research Articles Source Type: research

Mechanical thrombectomy performed in thrombosed fusiform aneurysm after surgery for craniopharyngioma in adult: Case report
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Mar 31. doi: 10.5507/bp.2021.018. Online ahead of print.ABSTRACTINTRODUCTION: Fusiform dilatation of the internal carotid artery (ICA) is reported as a possible complication of craniopharyngioma resection in childhood. Here, the authors describe such a complication in an adult patient who presented with acute symptomatic thrombosis 7 months after surgery.MATERIALS AND METHODS: A 45-year-old woman presented with left hemispheric stroke due to a thrombotic supraclinoid occlusion of the terminal ICA (so called "T" occlusion). Successful revascularisation was achieved w...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - April 6, 2021 Category: Biomedical Science Authors: Pavel Ryska Miroslav Lojik Naci Kocer Kamil Zelenak Tomas Cesak Petra Cimflova Aprajita Milind Bhorkar Eva Vitkova Antonin Krajina Source Type: research

Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients
In conclusion, poor metabolizers of CYP2C19 and TT groups of P2Y12 G52T may be significant predictors of poor clinical outcomes in elderly patients.PMID:33707344 | DOI:10.18632/aging.202799
Source: Aging - March 12, 2021 Category: Biomedical Science Authors: Jung-Joon Cha Jae Hyoung Park Hyung Joon Joo Soon Jun Hong Tae Hoon Ahn Byeong-Keuk Kim WonYong Shin Sung Gyun Ahn JungHan Yoon Yong Hoon Kim Yun-Hyeong Cho Woong Chol Kang Weon Kim Young-Hyo Lim Hyeon Cheol Gwon Woong Gil Choi Do-Sun Lim Source Type: research

Pages: 1  2  3  4  5  6  7  8  9