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Specialty: Biomedical Science
Condition: Thrombosis

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Total 134 results found since Jan 2013.

Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality
This study included 523 ischemic stroke patients and 400 control subjects. We investigated the association of three miRNA SNPs (miR-130bT>C,miR-200bT>C, andmiR-495A>C) with ischemic stroke prevalence and post-stroke mortality. In the multivariate logistic regression, there was no statistically significant difference in the distribution ofmiR-130bT>C,miR-200bT>C, ormiR-495A>C between the ischemic stroke and control groups. In the subgroup analysis based on ischemic stroke subtype, themiR-200b CC genotype was less frequently found in the large-artery atherosclerosis stroke subtype compared with controls (TT+CT vs CC; adjuste...
Source: PLoS One - September 6, 2016 Category: Biomedical Science Authors: Jinkwon Kim Source Type: research

Influence of Clinical Parameters and Anticoagulation on Intraprocedural Cerebral Microembolic Signals during Pulmonary Vein Isolation
by Robert Larbig, Ralf Dittrich, Simon Kochhaeuser, Patrick Leitz, Fatih Guener, Catharina Korsukewitz, Dirk Dechering, Christian Pott, Kristina Wasmer, Jan Schmitges, Monika Kerckhoff, Lars Eckardt, Gerold Moennig Objective We had the objective to determine the impact of clinical parameters and anticoagulation status on cerebral microembolic signals (MES) during pulmonary vein isolation (PVI) for atrial fibrillation (AF). Background Thromboembolism and stroke are the most feared complications of PVI. MES can help to evaluate embolic burden. It is unknown whether clinical parameters have an impact on embolic risk during PV...
Source: PLoS One - June 20, 2016 Category: Biomedical Science Authors: Robert Larbig Source Type: research

Analysis of mechanical parameters on the thromboembolism using a patient-specific computational model.
Abstract Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed from magnetic resonance angiography images, pulsatile flow and emboli with different sizes and material properties. Here, the fluid-structure interactions method was used to simulate the motion of deformable and rigid emboli through cerebral arteries. Hemodynamic changes in the circle of Willi...
Source: Biomechanics and Modeling in Mechanobiology - January 25, 2016 Category: Biomedical Science Authors: Khodaee F, Vahidi B, Fatouraee N Tags: Biomech Model Mechanobiol Source Type: research

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
Conclusion Although secreted platelet 5-HT does not appear to play a crucial role in the development of reperfusion injury after stroke, it is essential to amplify the second phase of platelet activation through SOCE and plays an important role in thrombus stabilization.
Source: PLoS One - January 22, 2016 Category: Biomedical Science Authors: Karen Wolf et al. Source Type: research

Eplerenone reduces arterial thrombosis in diabetic rats
Conclusions: Our study demonstrated the antithrombotic effect of EPL manifested by a decrease in the dynamics of thrombus formation and changes in its structure. The changes in thrombosis process were accompanied by antihaemostatic, profibrinolytic and anti-inflammatory effects. The aldosterone blockade with EPL seems to be an additional pharmacological strategy for the prevention and treatment of thrombotic disorders in diabetes.
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Zakrzeska, A., Gromotowicz-Popławska, A., Szemraj, J., Szoka, P., Kisiel, W., Purta, T., Kasacka, I., Chabielska, E. Tags: Original Articles Source Type: research

The Effect of Pre-Condition Cerebella Fastigial Nucleus Electrical Stimulation within and beyond the Time Window of Thrombolytic on Ischemic Stroke in the Rats
by Weiju Tang, Weiwei Dong, Peng Xie, Pengfei Cheng, Shunjie Bai, Yifei Ren, Gong Wang, Xiuying Chen, Chun Cui, Yuxiang Zhuang, Wen Huang Objective To investigate the effect of neurogenic neuroprotection conferred by cerebellar fastigial nucleus stimulation (FNS) and the role of PPARγ- mediated inflammation in a rat model of cerebral ischemia reperfusion. Methods After a continuous 1 hour fastigial nucleus electric stimulation, the male Sprague Dawley (SD) rats were given middle cerebral artery occlusion (MCAO) for 1, 3, 6, 9, 12 and 15 hours undergoing reperfusion with intravenous recombinant tissue plasminogen activator...
Source: PLoS One - May 27, 2015 Category: Biomedical Science Authors: Weiju Tang et al. Source Type: research

Thrombus Deflector Stent for Stroke Prevention: A Simulation Study
Atrial fibrillation (AF) is a dysfunction of heart rhythm and represents an increased predisposition to ischemic stroke in AF patients. It has been shown that the AF-induced hemodynamic conditions may contribute to the increased embolic propensity through the carotid arteries. We simulated a stroke-prevention device with a unique strut structure to deflect the trajectory of a blood clot to the carotid artery. We identified the important determinants of functionality in a device design using computational fluid dynamics simulations.
Source: Journal of Biomechanics - May 21, 2015 Category: Biomedical Science Authors: Hyo Won Choi, Jose A. Navia, Ghassan S. Kassab Source Type: research

Expanding use of new oral anticoagulants.
This article compares the pharmacological properties of the NOACs with those of warfarin, describes the clinical trial data with the NOACs in the approved indications, outlines the unmet medical needs that the NOACs address, highlights the potential limitations of the NOACs, and provides guidance on the optimal use of the NOACs. PMID: 25374671 [PubMed]
Source: F1000 Medicine Reports - December 1, 2014 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research

Unraveling modulators of platelet reactivity in cardiovascular patients using omics strategies: Towards a network biology paradigm
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Anne Zufferey , Mark Ibberson , Jean-Luc Reny , Ioannis Xenarios , Jean-Charles Sanchez , Pierre Fontana Platelets play an important role in the pathogenesis and the ischemic complications of atherosclerosis. Platelets may be activated by several different agonists, promoting the release of their granule contents and subsequent aggregation and thrombus formation; this leads to ischemic events such as myocardial infarction or stroke. Aspirin, the most popular antiplatelet agent, is a cornerstone in the treatment and prevention of ischemic...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Syntaxin-binding protein 5 exocytosis regulation: differential role in endothelial cells and platelets
Details of the pathophysiologic mechanisms that underlie complex disorders, such as the thrombo-occlusive events associated with myocardial infarction, stroke, and venous thromboembolism, are challenging to address. Recent advances have been made through the application of genome-wide association studies (GWAS) to identify genetic loci associated with plasma levels of procoagulant proteins and risk of thrombotic disease. GWAS have consistently identified the gene encoding syntaxin-binding protein 5 (STXBP5) in this context. STXBP5 is expressed in both endothelium and platelets, and SNPs within the STXBP5 locus have been as...
Source: Journal of Clinical Investigation - September 18, 2014 Category: Biomedical Science Authors: David Lillicrap Source Type: research

Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis
Expression of the gene encoding the S100 calcium–modulated protein family member MRP-14 (also known as S100A9) is elevated in platelets from patients presenting with acute myocardial infarction (MI) compared with those from patients with stable coronary artery disease; however, a causal role for MRP-14 in acute coronary syndromes has not been established. Here, using multiple models of vascular injury, we found that time to arterial thrombotic occlusion was markedly prolonged in Mrp14–/– mice. We observed that MRP-14 and MRP-8/MRP-14 heterodimers (S100A8/A9) are expressed in and secreted by platelets from WT mice and...
Source: Journal of Clinical Investigation - April 1, 2014 Category: Biomedical Science Authors: Yunmei Wang, Chao Fang, Huiyun Gao, Matthew L. Bilodeau, Zijie Zhang, Kevin Croce, Shijian Liu, Toshifumi Morooka, Masashi Sakuma, Kohsuke Nakajima, Shuichi Yoneda, Can Shi, David Zidar, Patrick Andre, Gillian Stephens, Roy L. Silverstein, Nancy Hogg, Alv Source Type: research

Keloids and non-diabetic kidney disease: Similarities and the APOL1–MYH9 haplotype as a possible genetic link
Abstract: Keloids and non-diabetic kidney disease are both fibrotic processes that disproportionately affect persons of African descent. Despite similarities in these conditions, the authors identified no studies to date investigating a shared genetic etiology. MYH9 and APOL1 are in linkage disequilibrium and have both been associated with non-diabetic kidney disease. MYH9 codes for a non-muscle myosin that is involved in cell adhesion and locomotion and is known to be overexpressed in keloids. Variations in APOL1 confer resistance to subspecies of Trypanosoma brucei, which may explain why otherwise deleterious genetic alt...
Source: Medical Hypotheses - September 6, 2013 Category: Biomedical Science Authors: Brett H. Keeling, Brent R. Taylor Tags: Articles Source Type: research

Local axial compressive mechanical properties of human carotid atherosclerotic plaques—characterisation by indentation test and inverse finite element analysis
Abstract: The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischaemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the appropriate treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques u...
Source: Journal of Biomechanics - May 9, 2013 Category: Biomedical Science Authors: Chen-Ket Chai, Ali C. Akyildiz, Lambert Speelman, Frank J.H. Gijsen, Cees W.J. Oomens, Marc R.H.M. van Sambeek, Aad van der Lugt, Frank P.T. Baaijens Tags: Papers Source Type: research

Psychiatric remission with warfarin: Should psychosis be addressed as plasminogen activator imbalance?
Conclusion: Our findings suggest that normalization of plasminogen activator levels in the brain may induce long-term remission of psychotic symptoms. Randomized controlled studies may help clarify the role of anticoagulation in the treatment of psychosis.
Source: Medical Hypotheses - December 3, 2012 Category: Biomedical Science Authors: Silvia Hoirisch-Clapauch, Antonio E. Nardi Tags: Articles Source Type: research