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Specialty: Neuroscience
Condition: Thrombosis

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Total 164 results found since Jan 2013.

Unfavorable Outcome of Thrombolysis in Chinese Patients with Cardioembolic Stroke: a Prospective Cohort Study.
CONCLUSIONS: Patients with cardioembolic stroke had more SICH after thrombolysis, and worse clinical outcome at 3-month follow-up compared with those with LAA. This emphasizes the importance of preventing cardioembolism. PMID: 26096605 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Wang XG, Zhang LQ, Liao XL, Pan YS, Shi YZ, Wang CJ, Wang YL, Liu LP, Zhao XQ, Wang YJ, Li D, Wang CX, Thrombolysis Implementation and Monitoring of acute ischemic Stroke in China (TIMS-China) Investigators Tags: CNS Neurosci Ther Source Type: research

Targeting neutrophils in ischemic stroke: translational insights from experimental studies
Frank R Sharp
Source: Journal of Cerebral Blood Flow and Metabolism - May 29, 2015 Category: Neuroscience Authors: Glen C JicklingDaZhi LiuBradley P AnderBoryana StamovaXinhua ZhanFrank R Sharp Tags: atherosclerosis cerebral ischemia immune system neutrophil stroke thrombus Source Type: research

Calcific emboli originating from the brachiocephalic trunk causing acute cerebral infarction and worm-like calcification in the right middle cerebral artery
We report, to our knowledge, the first patient with brachiocephalic trunk calcified plaque causing the ‘salted pretzel sign’ and worm-like calcification. Arterial stenosis or occlusion caused by atherosclerosis and thrombosis are responsible for the majority of cases of cerebral infarction. However, there are a number of other causes. Interestingly, these findings were not observed on a CT scan 10days before the stroke. Acute cerebral infarction with calcifications on unenhanced head CT scans should raise suspicion for disease in the carotid system. Identification of subtle findings of acute ischemic stroke on CT scans...
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research

In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors
Publication date: March 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 3 Author(s): Santosh B. Murthy , Yogesh Moradiya , Shreyansh Shah , Aditi Shastri , Eric M. Bershad , Jose I. Suarez Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were identified from the 2002–2011 USA Nationwide Inpatient Sample. We compared demographics, comorbidities, and outcomes between primary brain tumor-associated strokes (BT...
Source: Journal of Clinical Neuroscience - February 16, 2015 Category: Neuroscience Source Type: research

A study of ER stress in rat model of cerebral venous sinus thrombosis
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Hari Shanker Tiwari , Amit Kumar Tripathi , Durga Prasad Mishra , Jayantee Kalita , Usha Kant Misra Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. The role of endoplasmic reticulum (ER) stress markers is well documented in arterial stroke but has not been evaluated in venous stroke. The present study has been undertaken to investigate the role of ER stress in rodent model of CVST. For inducing CVST, a cranial window was made to expose superior sagittal sinus (SSS). A strip of filter paper soaked with 40% ferric chloride w...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research

A male Fabry disease patient treated with intravenous thrombolysis for acute ischemic stroke
We report a 38-year-old man with acute aphasia and a left M2 segment of the middle cerebral artery thrombus with no recanalization who was finally diagnosed with Fabry disease after left ventricular hypertrophy of undetermined cause had been identified. A gene test revealed a R227X mutation typical of Fabry disease with the classical phenotype. To our knowledge our patient is the first reported male Fabry patient who was given intravenous thrombolytic therapy and the first reported Fabry patient who received intravenous thrombolytic therapy between 3 and 4.5hours of the symptom onset. Despite favorable prognostic indicator...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

National data on stroke outcomes in Thailand
In conclusion, the prevalence and outcomes of stroke in Thailand were comparable with other countries. The era of thrombolytic therapy has just begun in Thailand.
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke
; Christoph Kleinschnitz
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Michael K SchuhmannPeter KraftGuido StollKristina LorenzSven G MeuthHeinz WiendlBernhard NieswandtTim SparwasserNiklas BeyersdorfThomas KerkauChristoph Kleinschnitz Tags: brain ischemia inflammation microcirculation T cells thrombosis Source Type: research

1. Epileptic seizures in pediatric stroke: Data from the Italian Registry for Childhood Thrombosis
According to data from the Italian Registry for Childhood Thrombosis (R.I.T.I.), in about half cases diagnosis of pediatric stroke occurs after 24h from clinical onset (Baggio et al., SINP2013). The aim of the present study was to evaluate the frequency of seizures at stroke onset and their correlation with time to diagnosis in the pediatric stroke patients in the R.I.T.I. We selected the R.I.T.I. children with first acute arterial (AIS) or venous (CSVT) cerebral infarction occurring between January 2007 and June 2012; we studied prevalence, characteristics and recurrence of epileptic seizures, focusing on diagnostic delay.
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: L. Baggio, S. Sartori, M. Nosadini, C. Gentilomo, P. Saracco, M. Agostini, B. Bassi, A. Palmieri, A.M. Laverda, P. Simioni, A. Suppiej, per il G.I.R.T.I. (Gruppo Italiano Registro Trombosi Infantili) Source Type: research

Effect of Sex and Age Interactions on Functional Outcome after Stroke.
Abstract Stroke is one of the leading causes of death and disability worldwide. Experimental and clinical studies showed that sex and age play an important role in deciding the outcome after stroke. At younger ages, males were shown to have a higher risk for stroke than females. However, this trend reverses in older ages particularly when females reach menopause. Many preclinical studies indicate that steroid hormones modulate the age-dependent differential stroke outcome. In addition, patterns of cell death pathways activated following cerebral ischemia are distinct between males and females, but independent of s...
Source: CNS Neuroscience and Therapeutics - November 18, 2014 Category: Neuroscience Authors: Kim T, Vemuganti R Tags: CNS Neurosci Ther Source Type: research

Cerebral Thrombosis and Myeloproliferative Neoplasms
Abstract Myeloproliferative neoplasms (MPN) are acquired clonal disorders characterized by the proliferation of bone marrow myeloid cells. Different somatic mutations have been recently associated with MPN, the most common being JAK-2 V617F. Among MPN, polycythemia vera and essential thrombocythemia are particularly associated with an increased risk to develop thrombotic complications, either arterial or venous. Cerebrovascular events (stroke and transient ischemic attacks) are prevalent, accounting for approximately two-thirds of all events. Also cerebral vein thrombosis can complicate MPN and can be the first m...
Source: Current Neurology and Neuroscience Reports - September 14, 2014 Category: Neuroscience Source Type: research

IMM‐H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA‐and PI3K‐dependent Akt activation
Abstract Ischemic stroke is currently treated with thrombolytic therapy with a drawback to induce hemorrhagic transformation (HT) if applied beyond its relatively narrow treatment time window. The present study was designed to examine the role of IMM‐H004, a derivative of coumarin, in recombinant tissue plasminogen activator (tPA)‐induced HT. Rats subjected to 6 h of thromboembolic occlusion or middle cerebral artery occlusion received tPA with or without IMM‐H004. Delayed tPA intervention drastically increased the risk of HT and exaggerated the ischemic injury. To assess the effect of IMM‐H004 on delayed treatmen...
Source: European Journal of Neuroscience - March 20, 2014 Category: Neuroscience Authors: Wei Zuo, Jiao Chen, Shuai Zhang, Jia Tang, Hang Liu, Dongming Zhang, Naihong Chen Tags: Research Report Source Type: research

Impact of Carotid Atherosclerosis Combined with Hypercholesterolemia on Cerebral Microvessels and Brain Parenchyma in a New Complex Rat Model.
The objective of this study was to develop a new model of hypercholesterolemia plus carotid injury and to investigate the impact of carotid atherosclerosis combined with hypercholesterolemia in the rat brain. The complex rat model was developed by carotid injury induced by an air-drying endothelial denudation method after high cholesterol diet for 2 weeks. Plasma cholesterol, carotid pathomorphology, oxidative stress and inflammation in cerebral microvessels and brain parenchyma were measured at 7, 14 and 28 days after carotid surgery. The results showed that plasma concentrations of total cholesterol and low density lip...
Source: Neurochemical Research - January 29, 2014 Category: Neuroscience Authors: Zhang L, Ya B, Yang P, Sun F, Zhang L, Li Y, Li L Tags: Neurochem Res Source Type: research

113. Neurophysiology in neonatal stroke undergoing therapeutic hypotermia: An illustrative case
We report EEG monitoring and EP in a neonate with stroke due to internal carotid thrombosis who underwent TH. Case Report: A female infant born at 38 GA, BW 2730 gr (10°ile), was recruited for TH at 3h of life, because of Sarnat 2 plus pH
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: E. Toffoli, D. De Carlo, A. Cappellari, E. Cainelli, D. Trevisanuto, A. Suppiej Tags: Society Proceedings Source Type: research