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Specialty: Neuroscience
Condition: Thrombosis
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Total 164 results found since Jan 2013.
Platelet-activating factor antagonist-based intensive antiplatelet strategy in acute ischemic stroke: A propensity score matched with network pharmacology analysis
CONCLUSIONS: An intensive antiplatelet strategy of DGMI plus traditional antiplatelet agents is effective in treating AIS and may work by mediating post-stroke inflammation and thrombosis.PMID:37435773 | DOI:10.1111/cns.14331
Source: CNS Neuroscience and Therapeutics - July 12, 2023 Category: Neuroscience Authors: Xiaoyan Han Youjia Li Xuemin Chen Dong Pan Junning Mo Jiaming Qiu Yi Li Yan Chen Yan Huang Qingyu Shen Yamei Tang Source Type: research
Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
CONCLUSION: A systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.PMID:37365966 | DOI:10.1111/cns.14321
Source: CNS Neuroscience and Therapeutics - June 27, 2023 Category: Neuroscience Authors: Yifan Zhou Huimin Jiang Huimin Wei Xuechun Xiao Lu Liu Xunming Ji Chen Zhou Source Type: research
Modulation of the autophagy ‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
We report for the first time that the protective effect of β-hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D-BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D-BHB notably reduced the activation of the PERK and IRE1α branches of the unfolded protein response (UPR), attenuating protein synthesis inhibition and preventing endoplasmic reticulum stress. Together our results support the therapeutic use of D-BHB treatment post-ischemia, by preventing the loss of proteos...
Source: Journal of Neurochemistry - June 17, 2023 Category: Neuroscience Authors: Teresa Montiel,
Juan Carlos G ómora‐García,
Cristian Gerónimo‐Olvera,
Yessica Heras‐Romero,
Berenice N. Bernal‐Vicente,
Xochitl Pérez‐Martínez,
Luis B. Tovar‐y‐Romo,
Lourdes Massieu Tags: ORIGINAL ARTICLE Source Type: research
Advances in Management of the Stroke Etiology One-Percenters
AbstractPurpose of ReviewUncommon causes of stroke merit specific attention; when clinicians have less common etiologies of stoke in mind, the diagnosis may come more easily. This is key, as optimal management will in many cases differs significantly from “standard” care.Recent FindingsRandomized controlled trials (RCT) on the best medical therapy in the treatment of cervical artery dissection (CeAD) have demonstrated low rates of ischemia with both antiplatelet and vitamin K antagonism. RCT evidence supports the use of anticoagulation with vitamin K antagonism in “high-risk” patients with antiphospholipid antibody...
Source: Current Neurology and Neuroscience Reports - May 29, 2023 Category: Neuroscience Source Type: research
A Nomogram Model for Predicting Prognosis in Spontaneous Intracerebral Hemorrhage Patients
CONCLUSIONS: ICH score, GCS score, irregular shape, uneven density, IVH relation, surgery are easily available indicators to assist neurologists in formulating the most appropriate therapy for every intracranial hemorrhage patient. Further large prospective clinical trials are needed to obtain more integrated and reliable conclusions.PMID:36992585 | DOI:10.31083/j.jin2202042
Source: Journal of Integrative Neuroscience - March 30, 2023 Category: Neuroscience Authors: Yunjie Li Xia Liu Jingxuan Wang Chao Pan Zhouping Tang Source Type: research
