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Specialty: Neurosurgery
Condition: Thrombosis

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Total 559 results found since Jan 2013.

First case of ischemic stroke which happened during continuous intravenous infusion of rt-PA
We present a patient with left lower limb ischemia, treated by CDT, in which symptoms of stroke, proved to have ischemic etiology, started during continuous intra-arterial infusion of rt-PA. As the patient presented with the history of atrial fibrillation, the most probable mechanism of stroke was related to detachment of possible intra-atrial thrombus. Ischemic stroke which happened during intra-arterial thrombolysis with rt-PA has never been mentioned in literature yet and the case stands for the statement that very effective causative treatment of ischemic stroke with rt-PA is not sufficient to “prevent” ischemic st...
Source: Polish Journal of Neurology and Neurosurgery - April 2, 2017 Category: Neurosurgery Source Type: research

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials involvi...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research

Mechanical Thrombectomy with Solitaire Stent Retrieval for Acute Cardioembolic Stroke.
Conclusion: Some cases of cardioembolic stroke are resistant to MTSR and may need other treatment modalities. Careful interpretation of angiogram may be helpful to the decision. PMID: 29142621 [PubMed]
Source: Journal of Korean Neurosurgical Society - November 18, 2017 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Efficacy of Combining Proximal Balloon Guiding Catheter and Distal Access Catheter in Thrombectomy with Stent Retriever for Anterior Circulation Ischemic Stroke.
CONCLUSION: The combined technique needs lesser attempts, decreases distal migration, increases TICI 3 reperfusion and achieves better clinical outcomes. PMID: 31290296 [PubMed]
Source: Journal of Korean Neurosurgical Society - July 12, 2019 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

E-005 Preliminary results of the SUMMIT NZ ischemic stroke trial: MonoPoint(R) embolectomy featuring a novel 088 aspiration catheter and specialized delivery catheter
ConclusionsPreliminary findings suggest that first-line aspiration embolectomy using a novel MonoPoint® system including an 0.088" inner diameter aspiration catheter achieves a high rate of arterial revascularization with an acceptable safety profile. A full report on enrollment and results are to be presented.Disclosures S. Brew: 1; C; Route 92 Medical. 2; C; Route 92 Medical, Microvention. B. McGuinness: 1; C; Route 92 Medical. 2; C; Route 92 Medical. J. Caldwell: 1; C; Route 92 Medical. 2; C; Route 92 Medical. S. Lee: 1; C; Route 92 Medical. P. Barber: None. A. Holden: 2; C; Medtronic, Gore, Boston Scientific. T. Wu...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Brew, S., McGuinness, B., Caldwell, J., Lee, S., Barber, P., Holden, A., Wu, T., Krauss, M., Laing, A., Collecutt, W., Liebeskind, D., Hetts, S. Tags: Electronic poster abstracts Source Type: research

E-067 Importance of First Pass Reperfusion in Endovascular Stroke Care - Insights from STAR
ConclusionThis analysis of a large, multi-center stroke database confirms the importance of first pass reperfusion in endovascular stroke care.Disclosures I. Maier: None. M. Psychogios: None. J. Liman: None. S. Al Kasab: None. E. Almallouhi: None. A. Alawieh: None. S. Wolfe: None. K. Fargen: None. A. Arthur: None. N. Goyal: None. T. Dumont: None. P. Kan: None. J. Kin: None. R. De Leacy: None. J. Osbun: None. A. Rai: None. P. Jabbour: None. J. Grossberg: None. M. Park: None. R. Starke: None. R. Crosa: None. A. Spiotta: None. D. Behme: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Maier, I., Psychogios, M., Liman, J., Al Kasab, S., Almallouhi, E., Alawieh, A., Wolfe, S., Fargen, K., Arthur, A., Goyal, N., Dumont, T., Kan, P., Kin, J., De Leacy, R., Osbun, J., Rai, A., Jabbour, P., Grossberg, J., Park, M., Starke, R., Crosa, R., Spi Tags: Electronic poster abstracts Source Type: research

O-066 Actin imparts thrombolysis resistance in acute ischemic stroke clots - gelsolin accelerates TPA mediated thrombolysis
ConclusionActin is one of the major structural components of AIS clots and could be responsible for fibrinolytic resistance. Targeting actin molecules would positively impact improving the outcome of recanalization of LVO-AIS.Abstract O-066 Figure 1Disclosures S. Arul: None. D. Dai: None. O. Mereuta: None. S. Ghozy: None. W. Brinjikji: None. D. Kallmes: None. R. Kadirvel: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Arul, S., Dai, D., Mereuta, O., Ghozy, S., Brinjikji, W., Kallmes, D., Kadirvel, R. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

E-048 Antithrombotics for emergent stenting in acute stroke
ConclusionTirofiban continuous infusion is a safe and possibly effective strategy for emergent stenting in acute ischemic stroke.Disclosures S. Lahoti: None. K. Limaye: None. C. Zevallos: None. K. Dlouhy: None. M. Hayakawa: None. E. Samaniego: None. D. Hasan: None. S. Ortega: 2; C; Medtronic, Stryker Neurovascular, Microvention. C. Derdeyn: 1; C; Siemens Healthineers. 4; C; Euphrates Vascular, Inc. 6; C; DSMB: Penumbra (MIND), NoNO (ESCAPE NA1 and FRONTIER).
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lahoti, S., Limaye, K., Zevallos, C., Dlouhy, K., Hayakawa, M., Samaniego, E., Hasan, D., Ortega, S., Derdeyn, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-092 Use of balloon-guide catheters for concomitant mechanical thrombectomy and carotid revascularization with flow-arrest results in significantly lower sICH and better 90-day outcomes in tandem stroke patients
ConclusionUse of balloon-guide catheters for concomitant mechanical thrombectomy and carotid revascularization with flow-arrest results in significantly lower sICH and better 90-day outcomes in tandem stroke patients.Disclosures A. Baig: None. J. Neumaier: None. M. Waqas: None. A. Monteiro: None. J. Cappuzzo: None. W. Khawar: None. B. Donnelly: None. E. Levy: 2; C; : Claret Medical, GLG Consulting, Guidepoint Global, Imperial Care, Medtronic, Rebound, StimMed, Misionix, Mosiac, Clarion, IRRAS. 4; C; NeXtGen Biologics, RAPID Medical, Claret Medical, Cognition Medical, Imperative Care, Rebound Therapeutics, StimMed, Three Ri...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Baig, A., Neumaier, J., Waqas, M., Monteiro, A., Cappuzzo, J., Khawar, W., Donnelly, B., Levy, E., Siddiqui, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-096 COVID status is related to clot burden during thrombectomy in acute stroke patients
ConclusionOf 230 patients included in this interim analysis across 24 centers in the United States, between 02/2021 and 01/2022, 16 patients had a history of COVID. Comparing COVID-positive to non-positive, patients with COVID were younger (median 66.5 years vs 71.5 years, p 0.042), and had more intracranial clot by weight (median 101.0 mg vs 42.0 mg, p 0.047). There was a trend toward COVID positive patients to have more clot volume (median 180 cc vs 77.5 cc p 0.08), suggesting the difference was a higher clot burden instead of more density to the thrombus. These results suggest different histopathological characteristics...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Effect of drug use in the treatment of acute ischemic stroke: A scoping review
CONCLUSION: Evidence for thrombolytic and thrombectomy treatment in drug users remains limited. Controlled studies are needed to examine complication profile and outcomes following thrombolytic and thrombectomy treatment in this population.PMID:36128166 | PMC:PMC9479649 | DOI:10.25259/SNI_561_2022
Source: Surgical Neurology International - September 21, 2022 Category: Neurosurgery Authors: Nisha Dabhi Panagiotis Mastorakos Jennifer D Sokolowski Ryan T Kellogg Min S Park Source Type: research