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Condition: Thrombosis
Procedure: Transplants

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Total 252 results found since Jan 2013.

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis
CONCLUSIONS: The comparative effects of different ESAs on blood transfusions, death (any cause and cardiovascular), major cardiovascular events, myocardial infarction, stroke, vascular access thrombosis, kidney failure, fatigue and breathlessness were uncertain.PMID:36791280 | DOI:10.1002/14651858.CD010590.pub3
Source: Cochrane Database of Systematic Reviews - February 15, 2023 Category: General Medicine Authors: Edmund Ym Chung Suetonia C Palmer Valeria M Saglimbene Jonathan C Craig Marcello Tonelli Giovanni Fm Strippoli Source Type: research

Identifying patients at risk: multi ‐centre comparison of HeartMate 3 and HeartWare left ventricular assist devices
ConclusionsHM3 patients have a significantly better survival and a lower incidence of ischaemic strokes and pump thrombosis than HVAD patients. This survival difference persisted after 2  years of implantation. Additional research using post-operative variables is warranted to identify which HVAD patients need an upgrade to HM3 or expedited transplantation.
Source: ESC Heart Failure - February 17, 2023 Category: Cardiology Authors: Lieke Numan, Daniel Zimpfer, Osnat Itzhaki Ben Zadok, Emmeke Aarts, Michiel Morshuis, Sabina P.W. Guenther, Julia Riebandt, Dominik Wiedemann, Faiz Z. Ramjankhan, Anne ‐Marie Oppelaar, Tuvia Ben‐Gal, Binyamin Ben‐Avraham, Folkert W. Asse Tags: Original Article Source Type: research

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis
CONCLUSIONS: The comparative effects of different ESAs on blood transfusions, death (any cause and cardiovascular), major cardiovascular events, myocardial infarction, stroke, vascular access thrombosis, kidney failure, fatigue and breathlessness were uncertain.PMID:36791280 | PMC:PMC9924302 | DOI:10.1002/14651858.CD010590.pub3
Source: Cochrane Database of Systematic Reviews - February 15, 2023 Category: General Medicine Authors: Edmund Ym Chung Suetonia C Palmer Valeria M Saglimbene Jonathan C Craig Marcello Tonelli Giovanni Fm Strippoli Source Type: research

E-260 Bilateral cerebral arteriovenous shunting through pial and perforating vessels with multiple strokes and intraparenchymal hemorrhages in a patient with hepatopulmonary syndrome
This study presents a unique case of a 54-year-old male patient with a history of stroke, liver cirrhosis, portal vein thrombosis, hypertension, diabetes, and bladder cancer, who experienced multiple episodes of intracranial hemorrhages, stroke and worsening confusion over the past five years. The patient‘s clinical presentation raised suspicion for an underlying occult vasculopathy. Digital subtraction angiography (DSA) revealed multiple curvilinear, irregular, bilateral pial vessels with early high-flow arteriovenous shunting, consistent with vascular shunting that is associated with liver cirrhosis. The patient&ls...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Aljeradat, B., Koneru, M., Oliveira, R., Shaikh, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Sailing between Scylla and Charybdis: oral long-term anticoagulation in dialysis patients
End-stage renal disease (ESRD) patients exhibit an increased risk of bleeding compared with non-chronic kidney disease (CKD) patients due to uraemic platelet dysfunction, altered vessel architecture and other factors. This renders any long-term oral anticoagulation potentially difficult. While there is little doubt that ESRD patients with recurrent thromboembolism or a mechanical cardiac valve should receive vitamin K antagonists (coumarins), the use of coumarins in ESRD patients with atrial fibrillation is a matter of debate. In non-CKD patients, current guidelines strongly recommend the use of oral anticoagulants for str...
Source: Nephrology Dialysis Transplantation - March 5, 2013 Category: Urology & Nephrology Authors: Kruger, T., Brandenburg, V., Schlieper, G., Marx, N., Floege, J. Tags: CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease
Summary Sickle cell disease (SCD) is associated with vascular complications including premature stroke. The role of atherothrombosis in these vascular complications is unclear. To determine the effect of SCD on atherosclerosis and thrombosis, mice with SCD along with controls were generated by transplantation of bone marrow from mice carrying the homozygous sickle cell mutation (Hbbhβs/hβs) or wild‐type mice (Hbb+/+) into C57BL6/J or apolipoprotein E deficient (Apoe−/−) recipient mice. At the time of sacrifice, 23–28 weeks following bone marrow transplantation, anaemia, reticulocytosis, and splenomegaly were pre...
Source: British Journal of Haematology - April 17, 2013 Category: Hematology Authors: Hui Wang, Wei Luo, Jintao Wang, Chiao Guo, Stephanie L. Wolffe, Julia Wang, Eddy B. Sun, Kori N. Bradley, Andrew D. Campbell, Daniel T. Eitzman Tags: Research Paper Source Type: research

Evaluation of Inflow Cannulation Site for Implantation of Right‐Sided Rotary Ventricular Assist Device
Abstract Right heart dysfunction is one of the most serious complications following implantation of a left ventricular assist device, often leading to the requirement for short‐ or long‐term right ventricular assist device (RVAD) support. The inflow cannulation site induces major hemodynamic changes and so there is a need to optimize the site used depending on the patient's condition. Therefore, this study evaluated and compared the hemodynamic influence of right atrial cannulation (RAC) and right ventricular cannulation (RVC) inflow sites. An in vitro variable heart failure mock circulation loop was used to compare RA...
Source: Artificial Organs - April 29, 2013 Category: Transplant Surgery Authors: Shaun D. Gregory, Mark J. Pearcy, John Fraser, Daniel Timms Tags: Main Text Article Source Type: research

Impact of Pump Replacement on Outcome in Advanced Heart Failure Patients With Left Ventricular Assist System
In conclusion, pump replacement for thrombus formation may have a strong association with worse outcome. Our results reconfirm the clinical importance of device thrombus in the management of LVAS.
Source: Artificial Organs - May 20, 2013 Category: Transplant Surgery Authors: Yoshio Iwashima, Masanobu Yanase, Takeshi Horio, Osamu Seguchi, Yoshihiro Murata, Tomoyuki Fujita, Koichi Toda, Yuhei Kawano, Takeshi Nakatani Tags: Main Text Article Source Type: research

Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque
Abstract: Introduction: There have been no satisfactory therapies on stabilizing and repairing ruptured plagues nowadays, which are the fundamental causes of acute coronary syndrome (ACS) and stroke. The aim of this study was to investigate the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in stabilizing and repairing ruptured plaques.Materials and Methods: 28 male New Zealand rabbits were randomly divided into 2 groups after establishment of atherosclerotic disrupted plaque model by liquid nitrogen frostbite: MSCs transplantation group and control group. MSCs were isolated, cultured in vitro, and labe...
Source: Thrombosis Research - April 25, 2013 Category: Hematology Authors: Shun-Miao Fang, Da-Yong Du, Yun-Tian Li, Xing-Li Ge, Peng-Tao Qin, Qing-Hua Zhang, Yang Liu Tags: Platelets and Cell Biology Source Type: research

248 * long-term circulatory support with rotary blood pumps: is it worthwhile?
Conclusions: Patients on long-term support have an excellent haemodynamic profile and show an acceptable risk-benefit ratio. Although heart transplantation remains the ultimate target at present, our data show that long-term circulatory support is a viable option with the potential to become a more permanent solution in the long-term.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Capoccia, M., Sabashnikov, A., Mohite, P. N., Garcia Saez, D., Zych, B., Hards, R., Bowles, C. T., Moza, A., De Robertis, F., Bahrami, T., Amrani, M., Banner, N. R., Simon, A. R. Tags: Left ventricular assist devices II: Long-term support Source Type: research

Erythropoiesis-stimulating agents in chronic kidney disease: What have we learned in 25 years?
Abstract Since the pioneering studies by Eschbach et al in 1987, erythropoiesis-stimulating agents (ESAs) have become the mainstay of anemia therapy in chronic kidney disease (CKD) patients. The introduction of ESAs 25 years ago markedly improved the lives of many patients with CKD, who until then had severe, often transfusion-dependent anemia. However, randomized controlled trials demonstrate an increased risk for cardiovascular events such as stroke, thrombosis, and death at nearly normal hemoglobin concentrations and higher ESA doses in CKD. By contrast, kidney transplant recipients may represent a unique popu...
Source: J Formos Med Assoc - September 30, 2013 Category: Journals (General) Authors: Hung SC, Lin YP, Tarng DC Tags: J Formos Med Assoc Source Type: research

Chronic renal disease is associated with stroke and thromboembolism in atrial fibrillation independently from gender
We have read with great interest the article by Guo and colleagues concerning renal dysfunction (defined as the presence of chronic dialysis, renal transplantation or an estimated glomerular filtration rate, eGFR,
Source: International Journal of Cardiology - May 3, 2013 Category: Cardiology Authors: Rui Providência, Sérgio Barra, Luís Paiva Tags: Letters to the Editor Source Type: research

Anticoagulation with a new oral anticoagulant in heart transplant recipients
Rivaroxaban is now accepted for prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation with one or more risk factors, and treatment and secondary prevention of deep vein thrombosis and pulmonary embolism. Nothing is known about the use of this new anticoagulant in transplanted patients. Here we report a series of heart transplant recipients treated with rivaroxaban and followed at our transplantation center.
Source: International Journal of Cardiology - July 25, 2013 Category: Cardiology Authors: Pierre Ambrosi, Bernard Kreitmann, William Cohen, Gilbert Habib, Pierre Morange Tags: Letters to the Editor Source Type: research

Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model Basic Sciences
Conclusions— In the presented experimental setting, complete loss of mural cells acts as a driving force for aneurysm growth and rupture. The findings suggest that aneurysms missing mural cells are incapable to organize a luminal thrombus, leading to recanalization, increased inflammatory reaction, severe wall degeneration, and eventual rupture.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Marbacher, S., Marjamaa, J., Bradacova, K., von Gunten, M., Honkanen, P., Abo-Ramadan, U., Hernesniemi, J., Niemela, M., Frosen, J. Tags: Basic Sciences Source Type: research

Use of Left Ventricular Assist Device (HeartMate II): A Singapore Experience
We report our experience with the HeartMate II (HMII) LVAD (Thoratec Corporation, Pleasanton, CA, USA) as a bridge‐to‐heart transplant in our center from 2009 to 2012. This was a retrospective review of 23 consecutive patients who underwent HMII LVAD implantation in our center between May 2009 and December 2012. All patients were classified as Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) levels 1 to 3 and underwent LVAD implantation as a bridge‐to‐heart transplant. There were 17 male and 6 female patients. The mean age was 43.6 years old (range 14 to 64). The etiologies of heart fa...
Source: Artificial Organs - January 7, 2014 Category: Transplant Surgery Authors: Choon Pin Lim, Cumaraswamy Sivathasan, Teing Ee Tan, Chong Hee Lim, Ka Lee Kerk, David Kheng Leng Sim Tags: Main Text Article Source Type: research