Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model [Basic Sciences]

Conclusions—
In the presented experimental setting, complete loss of mural cells acts as a driving force for aneurysm growth and rupture. The findings suggest that aneurysms missing mural cells are incapable to organize a luminal thrombus, leading to recanalization, increased inflammatory reaction, severe wall degeneration, and eventual rupture.

Source: Stroke - December 23, 2013 Category: Neurology Authors: Marbacher, S., Marjamaa, J., Bradacova, K., von Gunten, M., Honkanen, P., Abo-Ramadan, U., Hernesniemi, J., Niemela, M., Frosen, J. Tags: Basic Sciences Source Type: research