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Condition: Pneumonia

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Total 1895 results found since Jan 2013.

Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques
J Am Chem Soc. 2023 Aug 2. doi: 10.1021/jacs.3c04981. Online ahead of print.ABSTRACTAtherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine cathepsin. However, the accurate measurement of cathepsin B (CTB) activity in plaques is challenging due to the low specificity and insufficient penetration depth of available atherosclerosis-associated cathepsin fluorescent probes, hampering reliable assessment of plaque vulnerability. To address these limitations, we added both lipophilic alkyl chain and hydr...
Source: Atherosclerosis - August 2, 2023 Category: Cardiology Authors: Yuan Ma Jinhui Shang Liuhui Liu Menghuan Li Xinyu Xu Hui Cao Li Xu Wei Sun Guosheng Song Xiao-Bing Zhang Source Type: research

The Functional Prognosis of Rescue Conscious Sedation During Mechanical Thrombectomy on Patients with Acute Anterior Circulation Ischemic Stroke: A Single-Center Retrospective Study
ConclusionCompared to LA, rescue CS during MT does  not significantly improve the 90 days of good prognosis and reduce the incidence of sICH and mortality in patients with anterior circulation AIS. However, it has a significantly increased risk of poststroke pneumonia (PSP), particularly in patients with dysphagia.
Source: Neurology and Therapy - August 2, 2023 Category: Neurology Source Type: research

As an inhibitor of norepinephrine release, dexmedetomidine provides no improvement on stroke-associated pneumonia in mice
Conclusion: The clinical use of DEX in stroke patients should be approached with caution, considering its inability to alleviate SAP symptoms and reduce the infarct area. Further research is necessary to fully understand the relationship between decreased CD3+ T cells and DEX’s influence on SAP.
Source: Frontiers in Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Source Type: research

E-049 Complications of middle meningeal artery embolization - a systematic review
ConclusionThe published literature suggests that MMA embolization is a generally well-tolerated procedure, but with a low risk of significant complications, including, but not limited to stroke, seizures, visual obscurations, and facial palsy. Further studies and sub-analyses are needed to fully characterize the incidence of such complications.Disclosures J. Gerstl: None. M. Shafi: None. S. Badikol: None. N. Nawabi: None. R. Mekary: None. M. Sukumaran: None. A. Kappel: None. A. Feroze: None. T. Smith: None. M. Aziz-Sultan: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gerstl, J., Shafi, M., Badikol, S., Nawabi, N., Mekary, R., Sukumaran, M., Kappel, A., Feroze, A., Smith, T., Aziz-Sultan, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

A meta-analysis evaluating efficacy and safety of colchicine for prevention of major cardiovascular events in patients with coronary artery disease
ConclusionsColchicine is an effective, relatively safe drug that could be considered for the treatment of CAD. However, we need to pay attention to the increasing occurrence of non-cardiovascular mortality and infection especially pneumonia possibly caused by colchicine.Graphical abstractEfficacy and safety of colchicine for patients with CAD.CAD coronary artery disease;RCTs randomized controlled trials;OR odds ratio;MACEs major adverse cardiovascular events;ACS acute coronary syndrome;NNT number needed to treat;NNH number needed to harm
Source: Clinical Research in Cardiology - July 28, 2023 Category: Cardiology Source Type: research

Association of underlying untreated cardiovascular risk factors with mortality and functional outcome in ischaemic stroke patients
Stroke is the third leading cause of death after ischaemic heart disease (IHD) and pneumonia in Malaysia.1 Aziz et al. reported that Malaysia's prevalence of ischaemic stroke had increased from 42.8 to 118.7 in 100,000 from 2010 to 2014. The report showed that 8-11% of ischaemic stroke patients died within 30 days while 56-61% survived with significant disability in Malaysia.2 Our previous study showed that patients with ischaemic stroke in Malaysia were younger, but the mortality rate was higher than in other countries.
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2023 Category: Neurology Authors: Teck Long King, Lee Len Tiong, Zariah Abdul  Aziz, Wan Chung Law Source Type: research

Locked-in syndrome responding to endovascular treatment
Conclusions This study found that EVT was associated with favorable functional outcomes and decreased mortality among patients with LiS. Baseline pc-ASPECTS and pneumonia were independent predictors of outcomes.
Source: Journal of NeuroInterventional Surgery - July 14, 2023 Category: Neurosurgery Authors: Song, J., Huang, J., Li, L., Yang, J., Yue, C., Liu, S., Kong, W., Luo, X., Liao, J., Du, J., Song, B., Liu, J., Tian, X., Tan, X., Li, F., Zi, W. Tags: Open access, Clinical neurology Source Type: research

Predictors of patient length of stay post stroke rehabilitation
Conclusion: Admission FIM score had an influence on patient outcomes and LOS. Patients with higher admission FIM motor scores may be able to participate in rehabilitation better and thus have shorter LOS. Being able to predict LOS on admission allows facility administrators to manage bed occupancy, human and clinical resources in post stroke rehabilitation.Keywords: Length of stay; predictors; rehabilitation; stroke.
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Thea Bijl, Witness Mudzi, Nicolette Comley-White Source Type: research

Long-Term Outcomes of Bovine versus Porcine Mitral Valve Replacement: A Multicenter Analysis
CONCLUSIONS: In this multicenter analysis of patients undergoing bioprosthetic MVR, there was no difference in perioperative complications and risk of reoperation of long-term survival after matching.PMID:37426448 | PMC:PMC10328727 | DOI:10.1155/2023/2111843
Source: Cardiology Research and Practice - July 10, 2023 Category: Cardiology Authors: M Broadwin N Ramkumar D J Malenka R D Quinn C S Ross F Hirashima J D Klemperer R S Kramer G L Sardella B Westbrook A W Discipio A Iribarne M P Robich Source Type: research