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Total 324 results found since Jan 2013.
Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review
Front Cardiovasc Med. 2023 Aug 30;10:1250263. doi: 10.3389/fcvm.2023.1250263. eCollection 2023.ABSTRACTThe dysbiosis of the oral microbiome and vascular translocation of the periodontopathic microorganism to peripheral blood can cause local and systemic extra-oral inflammation. Microorganisms associated with the subgingival biofilm are readily translocated to the peripheral circulation, generating bacteremia and endotoxemia, increasing the inflammation in the vascular endothelium and resulting in endothelial dysfunction. This review aimed to demonstrate how the dysbiosis of the oral microbiome and the translocation of oral...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Diego F Gualtero Gloria In és Lafaurie Diana Marcela Buitrago Yormaris Castillo Paula Katherine Vargas-Sanchez Diana Marcela Castillo Source Type: research
Interleukin-33 improves the neurogenesis of neural stem cells in perinatal brain after hypoxia-ischemia
Int Immunopharmacol. 2023 Aug 11;123:110778. doi: 10.1016/j.intimp.2023.110778. Online ahead of print.ABSTRACTPerinatal hypoxia-ischemia (HI) insult is an important cause of neonatal encephalopathy, and the effective therapeutic approaches are currently limited. Interleukin (IL)-33 acts as a member of the IL-1 superfamily and has been shown to be neuroprotective following experimental neonatal HI and adult stroke. Here, we explore the effect of IL-33 and its specific receptor ST2 axis on endogenous neurogenesis in neonatal brain after HI. ST2 was found on the surface of NSCs, and the expression of ST2 was further enhanced ...
Source: International Immunopharmacology - August 13, 2023 Category: Allergy & Immunology Authors: Jing Tian Jieqiong Zhu Qiuxiang Fan Xiaotian Luo Qianying Nie Jingwei Yu Xiaoyong Wu Yanli Tang Tao Liu Hui Yin Source Type: research
"Lifting Yang to Dredging Du Meridian Manipulation" acupuncture alleviates cerebral ischemia-reperfusion injury by mediating the NF- κB pathway
CONCLUSIONS: LYDD acupuncture ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB pathway activity.PMID:37414270 | DOI:10.1016/j.brainres.2023.148477
Source: Brain Research - July 6, 2023 Category: Neurology Authors: Xiahui Zhang Lei Ma Meifang Liu Tao Zhu Zhilin Huang Youlong Xiong Ziyi Wang Jing Shi Source Type: research
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke
Sci Signal. 2023 Jun 6;16(788):eadd6364. doi: 10.1126/scisignal.add6364. Epub 2023 Jun 6.ABSTRACTBrain swelling causes morbidity and mortality in various brain injuries and diseases but lacks effective treatments. Brain swelling is linked to the influx of water into perivascular astrocytes through channels called aquaporins. Water accumulation in astrocytes increases their volume, which contributes to brain swelling. Using a mouse model of severe ischemic stroke, we identified a potentially targetable mechanism that promoted the cell surface localization of aquaporin 4 (AQP4) in perivascular astrocytic endfeet, which compl...
Source: Science Signaling - June 6, 2023 Category: Biomedical Science Authors: Jesse A Stokum Bosung Shim Serban Negoita Natalya Tsymbalyuk Orest Tsymbalyuk Svetlana Ivanova Kaspar Keledjian Joseph Bryan Mordecai P Blaustein Ruchira M Jha Kristopher T Kahle Volodymyr Gerzanich J Marc Simard Source Type: research
Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice
ConclusionThe adverse impact ofImmp2l+/ − on the brain after ischemia and reperfusion might be related to mitochondrial damage that involves depolarization of the mitochondrial membrane potential, inhibition of the mitochondrial respiratory complex III, and activation of mitochondria-mediated cell death pathways. These results suggest that patients with stroke carryingImmp2l+/ − might have worse and more severe infarcts, followed by a worse prognosis than those withoutImmp2l mutations.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - May 27, 2023 Category: Research Source Type: research
Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats
Cell Mol Life Sci. 2023 May 20;80(6):160. doi: 10.1007/s00018-023-04792-x.ABSTRACTWe previously reported that permanent ischemia induces marked dysfunction of the autophagy-lysosomal pathway (ALP) in rats, which is possibly mediated by the transcription factor EB (TFEB). However, it is still unclear whether signal transducer and activator of transcription 3 (STAT3) is responsible for the TFEB-mediated dysfunction of ALP in ischemic stroke. In the present study, we used AAV-mediated genetic knockdown and pharmacological blockade of p-STAT3 to investigate the role of p-STAT3 in regulating TFEB-mediated ALP dysfunction in rat...
Source: Cellular and Molecular Life Sciences : CMLS - May 20, 2023 Category: Cytology Authors: Yueyang Liu Xiaohang Che Xiangnan Yu Hanxiao Shang Peirui Cui Xiaoxiao Fu Xianda Lu Yuhuan Liu Chunfu Wu Jingyu Yang Source Type: research
