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Condition: Lupus
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Total 491 results found since Jan 2013.
Stroke is Different in Systemic Lupus Erythematosus: Implications for Survival and Functionality
J Rheumatol. 2021 Mar 1:jrheum.201209. doi: 10.3899/jrheum.201209. Online ahead of print.ABSTRACTUndoubtedly, individuals with systemic lupus erythematosus (SLE) are at higher risk for developing cerebrovascular disease than counterparts from the general population without SLE. In a metaanalysis of studies from around the world, the likelihood of individuals with SLE developing both ischemic and hemorrhagic stroke (intracerebral and/or subarachnoid hemorrhage) was more than 2 times that of the general population1 Risks for stroke appear to be highest soon after SLE diagnosis, and concomitant antiphospholipid syndrome (APS)...
Source: Journal of Rheumatology - March 2, 2021 Category: Rheumatology Authors: Marios Rossides Source Type: research
Patients with systemic lupus erythematosus face a high risk of cardiovascular disease: A systematic review and Meta-analysis
CONCLUSION: The results of this meta-analysis suggest that SLE patients have a higher risk of developing CVD compared with the general or healthy population, and the risk of CVD in LN patients is significantly higher than that in SLE patients.PMID:33636561 | DOI:10.1016/j.intimp.2021.107466
Source: International Immunopharmacology - February 26, 2021 Category: Allergy & Immunology Authors: Xiaohong Lu YanHua Wang Jing Zhang Dan Pu Nan Hu Jing Luo Qi An Lan He Source Type: research
Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy
ConclusionThese preliminary data suggest that combined conventional anti-inflammatory and antithrombotic therapy may be an effective treatment for Libman-Sacks endocarditis and its associated CVD and may obviate the need for high-risk valve surgery.
Source: PLoS One - February 16, 2021 Category: Biomedical Science Authors: Carlos A. Roldan Source Type: research
Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model.
CONCLUSIONS: This study supports the hypothesis that auto-antibodies to ANXA2 are an independent risk factor for cerebral thrombosis. Consequently, we propose screening for anti-ANXA2 antibodies should be more widely used and patients that exhibit the manifestations of APS should be closely monitored by physicians.
PMID: 33554716 [PubMed - as supplied by publisher]
Source: Lupus - February 7, 2021 Category: Rheumatology Authors: Weiss R, Bushi D, Mindel E, Bitton A, Diesendruck Y, Gera O, Drori T, Zmira O, Aharoni SA, Agmon-Levin N, Kashi O, Benhar I, Golderman V, Orion D, Chapman J, Shavit-Stein E Tags: Lupus Source Type: research
Comparison of patients with transient and sustained increments of antiphospholipid antibodies after acute ischemic stroke
ConclusionaPL was rather common in ischemic stroke patients regardless of age. Although the influence of transient positive aPL on ischemic stroke remains uncertain, two or more aPLs and the presence of anti- β2glycoprotein-I IgG may predict a diagnosis of APS.
Source: Journal of Neurology - February 6, 2021 Category: Neurology Source Type: research
A trial of antithrombotic therapy in patients with refractory migraine and antiphospholipid antibodies: A retrospective study of 75 patients.
CONCLUSIONS: There was a high rate of symptomatic response to antithrombotic therapy in this context and long-term follow up suggested an individualized symptom-derived antithrombotic regimen may be associated with a low bleeding risk. Our data support consideration of a 2-4 week trial of antithrombotic therapy, usually starting with antiplatelet therapy, in aPL-positive patients with refractory migraine, particularly if other treatment options have been exhausted. As a retrospective study, our data provide only Class IV level of evidence, but they suggest randomized controlled trials are warranted to validate these enco...
Source: Lupus - January 5, 2021 Category: Rheumatology Authors: Schofield JR, Hughes HN, Birlea M, Hassell KL Tags: Lupus Source Type: research
Aneurysms in primary antiphospholipid syndrome: a case-based review
This article review ed all published cases on APS and aneurysm and showed that women who presented with abortions and deep venous thromboses with a lupus anticoagulant are those patients more commonly affected by aneurysms in APS.
Source: Clinical Rheumatology - January 3, 2021 Category: Rheumatology Source Type: research
Comment on: Association of systemic lupus erythematosus with peripheral arterial disease: a meta-analysis of literature studies
Dear Editor, We read with great interest the article by Forteet al. [1] referring to a meta-analysis of studies evaluating the association between systemic lupus erythematosus (SLE) and peripheral arterial disease (PAD). Taking into consideration that SLE patients have an increased cardiovascular morbidity and mortality as well as the contrasting data that are available about the putative association between PAD and SLE, the authors nicely showed that SLE patients exhibit a ∼four-fold higher prevalence of PAD as compared with non-SLE controls individuals [1]. These results confirmed and extended previously published evid...
Source: Rheumatology - December 28, 2020 Category: Rheumatology Source Type: research
Galectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus.
CONCLUSIONS: Our study identifies serum G3BP as a novel predictor of VTE in SLE. Further studies are needed to understand the role of G3BP in VTE and translate this into clinical practice.
PMID: 33337998 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
