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The Most Promising Cancer-Fighter In Years
For a while now, I’ve been recommending a powerful antioxidant with the unpronounceable name, pyrroloquinoline quinine – or PQQ for short. And although I recommend this compound to almost everyone who comes to see me at my wellness clinic in South Florida because of its energy-giving qualities, I’ve also observed its extraordinary power to fight cancer. For years, I’ve seen PQQ work wonders with my older patients, because it keeps you feeling young by giving your cells extra energy. PQQ was first discovered back in 1979 by a team of Japanese scientists, who knew little about the substance, except that i...
Source: Al Sears, MD Natural Remedies - March 24, 2015 Category: Complementary Medicine Authors: Andrew Britton Tags: Anti-Aging antioxidants Cancer energy Source Type: news

Neuropathologic Features of Suicide Victims Who Presented With Acute Poststroke Depression: Significance of Association With Neurodegenerative Disorders
Abstract: To investigate the neuropathologic characteristics of poststroke depression (PSD) leading to suicide, we retrospectively selected deceased subjects who had been diagnosed as having early PSD. Cases were divided into subjects who had committed suicide and those who had not. Neuropathologic examinations, including immunohistochemistry, were conducted. Twenty-four subjects fulfilled criteria for early PSD; 11 of these had committed suicide, and the other 13 had not. Lesion type, size of stroke, and location of stroke were variable but did not differ significantly between the groups. Alzheimer disease–related patho...
Source: Journal of Neuropathology and Experimental Neurology - April 15, 2015 Category: Neurology Tags: Original Articles Source Type: research

Rethinking Retirement in the 21st Century
Conclusion In the 21st century, many seniors are not retiring from something. Instead, retirement is an opportunity for reinventing, reimagining and reconnecting to one's self, family, friends and community. Robert Browning once wrote, "Grow old along with me! The best is yet to be." By investing in your physical, mental and financial health today, you can help ensure that your best years are just ahead. Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of The Huffington Post. She is a Senior Fellow in Health Policy at New America and a Clinical Professor at Tufts and Georgetown University Sc...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health News Source Type: news

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Authors: Sriram CS, Jangra A, Bezbaruah BK, K V A, Sykam S Abstract Poly ADP-ribose polymerase (PARP-1), a DNA nick-sensor enzyme, is an abundant nuclear protein. Upon sensing DNA breaks, PARP-1 gets activated and cleaves NAD into nicotinamide and ADP-ribose and polymerizes the latter onto nuclear acceptor proteins including histones, transcription factors, and PARP-1 itself. Poly(ADP-ribosylation) mainly contributes to DNA repairing mechanism. However, oxidative stress-induced over-activation of PARP-1 consumes excess of NAD and consequently ATP, culminating into cell necrosis. This cellular suicide pathway has be...
Source: Frontiers in Bioscience - Scholar - January 12, 2016 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

U.S. Life Expectancy Falls As More People Die From Illnesses
Rising mortality from a variety of illnesses caused life expectancy for Americans to drop in 2015 for the first in more than two decades, according to a National Center For Health Statistics study released Thursday. The drop of 0.1 percent was small ― life expectancy at birth was 78.8 years in 2015, compared with 78.9 years in 2014. But it reverses a long trend, and the factors that led to it are worth looking at. Diseases caused more deaths in 2015 than they did the year before. Age-adjusted death rates increased overall by 1.2 percent, from 724.6 deaths per 100,000 standard population in 2014 to 733.1 in...
Source: Healthy Living - The Huffington Post - December 8, 2016 Category: Consumer Health News Source Type: news

Mortality Among Black Men in the USA
Conclusions and RelevanceTotal mortality significantly declined for black men from 2000 to 2014, and the overall B to W disparity narrowed to RR  = 1.21 (95% CI 1.20 to 1.23) in 2014. However, significant black disadvantages relative to white men persisted for 10 leading causes of death.
Source: Journal of Racial and Ethnic Health Disparities - February 23, 2017 Category: Global & Universal Source Type: research

Trends in educational inequalities in premature mortality in Belgium between the 1990s and the 2000s: the contribution of specific causes of deaths
Conclusion Absolute inequalities decreased in men while increasing in women; relative inequalities increased in both sexes. The PAFs decomposition revealed that targeting mortality inequalities from lung cancer, IHD, COPD in both sexes, suicide in men and stroke in women would have the largest impact at population level.
Source: Journal of Epidemiology and Community Health - March 6, 2017 Category: Epidemiology Authors: Renard, F., Gadeyne, S., Devleesschauwer, B., Tafforeau, J., Deboosere, P. Tags: Epidemiologic studies, Mortality and morbidity, Suicide (psychiatry), Health service research, Suicide (public health) Research reports Source Type: research

Mental Illness Is On The Rise But Access To Care Keeps Dwindling
More Americans than ever before are experiencing mental health problems, yet access to treatment for those issues is becoming more difficult to receive, a new study has found. A new analysis of data from the Centers for Disease Control and Prevention’s National Health Interview Survey shows that serious psychological distress, or SPD, defined as severe sadness and depressive symptoms that interfere with a person’s physical wellbeing, is on the rise just as resources for mental health treatment are declining.  Researchers from NYU’s Langone Medical Center analyzed almost a decade’s worth of data...
Source: Healthy Living - The Huffington Post - April 17, 2017 Category: Consumer Health News Source Type: news

Why Do We Choose To Survive After Tragedy?
Why did my brother warn me against reading this book? It’s so good! I thought to myself, as I quickly devoured the pages of JoJo Moyes bestseller titled Me Before You. It was an uplifting tale about a young man who rediscovers love and laughter after a devastating spinal cord injury left him in a dangerous pool of depression. Finding myself at times in my own, albeit more shallow, pool of depression, I knew this story was exactly what I needed to remind me that I could find meaning in my life after my stroke. As I continued reading, anticipating the feel-good happy ending with a girl saving the boy's life with the power ...
Source: Healthy Living - The Huffington Post - May 17, 2017 Category: Consumer Health News Source Type: news

Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study.
Conclusions: Compared to noncombat veterans in the United States, combat veterans have elevated rates of PTSD, suicide attempt, stroke, and chronic pain independent of other sociodemographic, military, and mental health factors. Younger combat veterans have elevated rates of PTSD, suicidal ideation, and migraine headaches, while older combat veterans have elevated rates of heart disease and heart attack. These results characterize the population-based burden of mental and physical health conditions in combat veterans. They further underscore the importance of age- and condition-sensitive screening, monitoring, and treatmen...
Source: The Primary Care Companion for CNS Disorders - June 30, 2017 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

General Medical, Mental Health, and Demographic Risk Factors Associated With Suicide by Firearm Compared With Other Means.
CONCLUSIONS: Medical providers should consider targeting suicide risk screening for patients with any mental disorder, TBI, epilepsy, HIV, psychogenic pain, stroke, and migraine. When suicide risk is detected, counseling on reducing access to lethal means should include both firearms and other means for at-risk groups. PMID: 29446332 [PubMed - as supplied by publisher]
Source: Psychiatric Services - February 17, 2018 Category: Psychiatry Tags: Psychiatr Serv Source Type: research

Job Stress-attributable Burden of Disease in Korea.
Conclusion: The present findings suggested that one-fifth of Korean workers were suffering from high job strain. Although the figures may not be accurate due to several assumptions, job stress is an important risk factor for health in working environment in Korea. PMID: 29915526 [PubMed - in process]
Source: J Korean Med Sci - June 18, 2018 Category: General Medicine Authors: Lee K, Kim I Tags: J Korean Med Sci Source Type: research