Stroke RSS Page 9

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Specialty: Cardiology
Condition: Hemorrhagic Stroke

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Total 1473 results found since Jan 2013.

Intensive Blood Pressure Control After Mechanical Thrombectomy for Acute Ischemic Stroke
Stroke. 2023 Apr 6. doi: 10.1161/STROKEAHA.122.041949. Online ahead of print.ABSTRACTOptimal blood pressure targets following successful mechanical thrombectomy remain uncertain. While some observational studies suggest that the relationship between blood pressure and outcomes follows a U-shaped curve, others suggest a linear relationship where lower is better. The recent BP-TARGET study (Blood Pressure Target in Acute Stroke to Reduce Hemorrhage After Endovascular Therapy) did not find a benefit to intensive blood pressure lowering regarding the risk of symptomatic intracranial hemorrhage, but it was not sufficiently powe...
Source: Atherosclerosis - April 6, 2023 Category: Cardiology Authors: Nicholas A Morris Gaurav Jindal Seemant Chaturvedi Source Type: research

Severe Bleeding Risk of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Stroke Prevention and Treatment in Patients with Atrial Fibrillation: A Systematic Review and Network Meta-Analysis
ConclusionBased on current evidence, for stroke prevention and treatment in patients with AF, the most safe DOAC is edoxaban in terms of fatal bleeding; dabigatran in terms of major bleeding and intracranial hemorrhage and apixaban in terms of gastrointestinal bleeding. However, given the nature of indirect comparisons, more high-quality evidence from head-to-head comparisons is still needed to confirm them.
Source: Cardiovascular Drugs and Therapy - April 1, 2023 Category: Cardiology Source Type: research

Clinical characteristics of endovascular treatment for acute ischemic stroke with atherosclerotic etiology: Factors associating its clinical outcome
CONCLUSION: The EVT for atherosclerotic AIS were effective and safe. Older age, more severe NIHSS score, lesions in the posterior circulation, and recanalization failure were the factors associated with poor clinical outcomes. It is important to recognize that these factors may aggravate the clinical response to this promising therapy, even in patient successful recanalization was attained.PMID:36989680 | DOI:10.1016/j.clineuro.2023.107680
Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Kota Kurisu Kazuki Uchida Tomohiro Okuyama Kei Miyata Yoshitaka Yamaguchi Minoru Ajiki Tatsuro Takada Masaaki Hokari Katsuyuki Asaoka Koji Itamoto Miki Fujimura Source Type: research

Association of Tirofiban With Functional Outcomes After Thrombectomy in Acute Ischemic Stroke Due to Intracranial Atherosclerotic Disease
CONCLUSION: In this post hoc analysis of the RESCUE BT trial, tirofiban was an effective and well-tolerated adjuvant medication of endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerosis. These findings need to be confirmed in future trials.PMID:36941074 | DOI:10.1212/WNL.0000000000207194
Source: Atherosclerosis - March 20, 2023 Category: Cardiology Authors: Hongfei Sang Dongjing Xie Yan Tian Thanh N Nguyen Jeffrey L Saver Raul G Nogueira Junxiong Wu Chen Long Zhenxuan Tian Zhizhou Hu Tao Wang Rongzong Li Yingbing Ke Xiurong Zhu Daizhou Peng Mingze Chang Lingfei Li Jie Ruan Deping Wu Wenjie Zi Qingwu Yang Fen Source Type: research

First-pass effect of mechanical thrombectomy for anterior circulation large vessel occlusion: incidence, predictors, and clinical impact. Insight from the ANGEL-ACT registry
CONCLUSIONS: FPE was achieved at a rate of 27.0% and associated with functional independence, decreased intraprocedural complications, and ICH. Non-ICA occlusion and underlying ICAD were predictors of FPE.PMID:36919613 | DOI:10.3171/2023.1.JNS222604
Source: Atherosclerosis - March 15, 2023 Category: Cardiology Authors: Xiaochuan Huo Dapeng Sun Thanh N Nguyen Raynald Baixue Jia Xu Tong Gaoting Ma Anxin Wang Ning Ma Feng Gao Dapeng Mo Zhongrong Miao ANGEL-ACT Study Group Source Type: research

Pharmacology and Clinical Development of Factor XI Inhibitors
This article reviews the rationale, pharmacology, results of medium or small phase 2 studies, and future perspectives of drugs inhibiting FXI.PMID:36913497 | DOI:10.1161/CIRCULATIONAHA.122.062353
Source: Circulation - March 13, 2023 Category: Cardiology Authors: Antonio Greco Claudio Laudani Marco Spagnolo Federica Agnello Denise Cristiana Faro Simone Finocchiaro Marco Legnazzi Maria Sara Mauro Placido Maria Mazzone Giovanni Occhipinti Carla Rochira Lorenzo Scalia Davide Capodanno Source Type: research

Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion
CONCLUSION: This is the first study to report the characteristics of intracranial plaque proximal to LVO in non-cardioembolic stroke. It provides potential evidence to support different aetiological roles of <50% stenotic vs ≥50% stenotic intracranial plaque in this population.PMID:36914215 | DOI:10.1136/svn-2022-002071
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Dan Wang Zi-Yang Shang Yu Cui Ben-Qiang Yang George Ntaios Hui-Sheng Chen Source Type: research

Cerebral amyloid angiopathy-related cardiac injury: Focus on cardiac cell death
Front Cell Dev Biol. 2023 Feb 24;11:1156970. doi: 10.3389/fcell.2023.1156970. eCollection 2023.ABSTRACTCerebral amyloid angiopathy (CAA) is a kind of disease in which amyloid β (Aβ) and other amyloid protein deposits in the cerebral cortex and the small blood vessels of the brain, causing cerebrovascular and brain parenchymal damage. CAA patients are often accompanied by cardiac injury, involving Aβ, tau and transthyroxine amyloid (ATTR). Aβ is the main injury factor of CAA, which can accelerate the formation of coronary artery atherosclerosis, aortic valve osteogenesis calcification and cardiomyocytes basophilic degen...
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Xiaofang Xu Huikang Xu Zhaocai Zhang Source Type: research

In-vitro antioxidant, lipoxygenase inhibitory, and in-vivo muscle relaxant potential of the extract and constituent isolated from Diospyros kaki (Japanese Persimmon)
This study excellently rationalizes the traditional usage of D. kaki in curing various diseases. Furthermore, the docking results indicate, that the isolated compound fits well into the active site of the lipoxygenase, and makes strong interactions with the target protein.PMID:36895410 | PMC:PMC9989937 | DOI:10.1016/j.heliyon.2023.e13816
Source: Atherosclerosis - March 10, 2023 Category: Cardiology Authors: Adil Mujawah Abdur Rauf Sami Bawazeer Abdul Wadood Hassan A Hemeg Saud Bawazeer Source Type: research

Emerging role of miRNAs in the regulation of ferroptosis
Front Mol Biosci. 2023 Feb 15;10:1115996. doi: 10.3389/fmolb.2023.1115996. eCollection 2023.ABSTRACTFerroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis. The im...
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Reza Mahmoudi-Lamouki Sepideh Kadkhoda Bashdar Mahmud Hussen Soudeh Ghafouri-Fard Source Type: research

Predictors of Serious Adverse Events and High-Level Cardiorespiratory Support in Patients Undergoing Transcatheter Pulmonary Vein Interventions
AbstractPatients with pulmonary vein stenosis (PVS) often require frequent transcatheter pulmonary vein (PV) interventions for management of restenosis. Predictors of serious adverse events (AEs) and need for high-level cardiorespiratory support (mechanical ventilation, vasoactive support, and/or extracorporeal membrane oxygenation) 48 h after transcatheter PV interventions have not been reported. This is a single-center retrospective cohort analysis of patients with PVS who underwent transcatheter PV interventions from 3/1/2014 to 12/31/2021. Univariate and multivariable analyses were performed using generalized estimat...
Source: Pediatric Cardiology - March 3, 2023 Category: Cardiology Source Type: research

Higher Leukocyte Count Is Associated with Lower Presence of Carotid Lipid-Rich Necrotic Core: A Sub-Study in the Plaque at RISK (PARISK) Study
CONCLUSIONS: The leukocyte count is inversely associated with the presence of LRNC in the atherosclerotic carotid plaque in patients with a recently symptomatic carotid stenosis. The exact role of leukocytes and inflammation in plaque vulnerability deserves further attention.PMID:36835906 | PMC:PMC9961713 | DOI:10.3390/jcm12041370
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Twan Jowan van Velzen Jeffrey Stolp Dianne van Dam-Nolen Mohamed Kassem Jeroen Hendrikse Marianne Eline Kooi Daniel Bos Paul J Nederkoorn Source Type: research

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