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Incidence of Stroke in the US Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) Cohort (S51.008)
Conclusions:In this large study of neurologist adjudicated stroke in a HIV cohort, the AS stroke incidence rate was 337.7. The stroke rate was higher in women, African-Americans and older ages. These incidence data, combined with additional risk factor analyses, and comparisons with non-HIV cohorts, will allow better understanding of stroke in HIV, with the ultimate goal of improved outcomes.Study Supported by: NIAID, NHLBI (5R24AI067039) and AHA (13GRNT14560022)Disclosure: Dr. Tirschwell has received research support from St. Jude Medical and Bayer. Dr. Chow has nothing to disclose. Dr. Becker has received personal compen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tirschwell, D., Chow, F., Becker, K., Marra, C., Zunt, J., Ho, E., Kalani, R., Huffer, A., Nance, R., Williams-Nguyen, J., Burkholder, G., Moore, R., Mathews, W., Eron, J., Drozd, D., Kitahata, M., Saag, M., Crane, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Post-Stroke Disability at a National Referral Hospital in Tanzania (P3.322)
Conclusions:In this low-resource setting, individuals with stroke face a severe burden of disability and high risk of mortality. The majority of participants experienced severe deficits following stroke, as assessed through NIHSS and mRS. While this study may be limited by referral bias, the high toll of disability among this population suggests that post-stroke disability places a significant burden on Tanzanian families and society.Study Supported by:This abstract was made possible with help from the Harvard University Center for AIDS Research (CFAR), an NIH funded program (P30 AI060354), subgrant to F. Mateen.Disclosure...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wibecan, L., Mmbando, T., Grundy, S., Klein, J., Mateen, F., Okengo, K. Tags: Global Health Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Stroke in HIV-infected African Americans: a retrospective cohort study
Abstract The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of African Americans with HIV infection and new-onset stroke admitted at the Johns Hopkins Hospitals (2000–2012). Multivariate linear regression was used to examine the association between potential predictors and odds of an unfavorable outcome, defined as a higher modified Rankin Scale (mRS) score on hospital discharge. African Americans comprised 105/125 (84 %) of HIV-inf...
Source: Journal of NeuroVirology - July 9, 2015 Category: Neurology Source Type: research

End-of-Life Care Decision-Making in Stroke
Stroke is one of the leading causes of death and long-term disability in the United States. Though advances in interventions have improved patient survival after stroke, prognostication of long-term functional outcomes remains challenging, thereby complicating discussions of treatment goals. Stroke patients who require intensive care unit care often do not have the capacity themselves to participate in decision making processes, a fact that further complicates potential end-of-life care discussions after the immediate post-stroke period. Establishing clear, consistent communication with surrogates through shared decision-m...
Source: Frontiers in Neurology - September 28, 2021 Category: Neurology Source Type: research

Rare stroke mechanisms in 4154 consecutive patients: causes, predictors, treatment, and outcomes
CONCLUSIONS: RMS occurred in 5.3% of a large population of consecutive AISs and are most frequently related to medical interventions, cancer, and vasculitis. RMS patients have less traditional risk factors but more systemic comorbidities, hemorrhagic transformations, recurrences, and a worse long-term outcome. Identification of RMS has direct implications for early treatment and long-term outcome.PMID:35994133 | DOI:10.1007/s10072-022-06344-w
Source: Cancer Control - August 22, 2022 Category: Cancer & Oncology Authors: Alex Vicino Gaia Sirimarco Ashraf Eskandari Dimitris Lambrou Philippe Maeder Vincent Dunet Patrik Michel Source Type: research

Intraoperative Neurophysiologic Monitoring of Surgical and Endovascular Treatment of Pediatric Arteriovenous Malformations (S55.002)
CONCLUSIONS:Persistent IONM changes had a strong correlation with new post-operative deficits. Transient IONM changes, including those resolving after alterations in surgical management or pre-embolization methohexital testing, had a much lower risk of new deficits. Therefore, IONM can be a useful tool in pediatric AVM cases, not only in predicting neurological compromise, but also in identifying when to alter management.Study Supported by:N/ADisclosure: Dr. Nguyen has nothing to disclose. Dr. Avila has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Cho has nothing to disclose. Dr. Le has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nguyen, V., Avila, S., Lee, L., Cho, S., Le, S., Lopez, J. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

ASPECT Score and Its Application to Vasospasm in Aneurysmal Subarachnoid Haemorrhage: a Case –Control Study
AbstractDelayed cerebral ischaemia (DCI) is a significant complication of aneurysmal subarachnoid haemorrhage (aSAH) and is strongly associated with poorer outcome. The Alberta Stroke Program Early Computer Tomography (ASPECT) score is an established scoring tool, used in acute ischaemic stroke, to quantify early ischaemic changes on CT head scans. We aim to identify if ASPECT scoring correlates with functional outcome in DCI following aSAH. Retrospective case –control study. Inclusion criteria: admission to the Department of Neurosurgery at Leeds Teaching Hospitals NHS Trust (a tertiary neurosurgical centre in the Unite...
Source: Translational Stroke Research - August 9, 2022 Category: Neurology Source Type: research

Clinical round-up
HIV and stroke The association between HIV infection and coronary heart disease and haemorrhagic stroke has already been described1–3 but less is known about ischaemic stroke. Sico et al4 looked at the risk factors for ischaemic stroke in HIV+ individuals as part of the Veterans Administration Cohort Study, a study of clinical and laboratory data sets collected from 99 688 US veterans. They compared HIV+ patients with HIV– controls matched for age, sex race/ethnicity and clinical site over a 6-year period from 2003 to 2009, and after women and those with baseline cardiovascular disease (CVD) or stroke were...
Source: Sexually Transmitted Infections - January 20, 2016 Category: Sexual Medicine Authors: Herbert, S., Haddow, L. Tags: Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Contraception, Drugs: obstetrics and gynaecology, Reproductive medicine, HIV / AIDS, Gonorrhoea, HIV infections, Health education, Smoking Clinical round-up Source Type: research

Cerebrovascular Disease and HIV in Singapore: A Single-Centre Study (P1.325)
Conclusions: Prevalence of CVS risk factors was significant in our population. Stroke in HIV patients may result from other disease mechanisms and carries significant mortality and morbidity. Fever at presentation suggests an infective etiology.Disclosure: Dr. Gan holds stock and/or stock options in a company which sponsored research in which Dr. Gan was involved as an investigator. Dr. Saini has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ng has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gan, E., Saini, M., Lee, C.-C., Ng, O.-T., Tan, K. Tags: HIV/AIDS Source Type: research

Neuron-Specific Markers and their Correlation with Neurological Scales in Patients with Acute Neuropathologies
AbstractIn predicting outcomes in patients with acute brain injury, current practice focuses special attention on neuron-specific proteins that reliably reflect the severity of the lesion. Further studies of molecular markers and their specificity and sensitivity could contribute to broadening the understanding of pathophysiological, diagnostic, and prognostic methods, which is vital to reducing the mortality and disability associated with these critical conditions. The purpose of this study was to assess the biomarkers of brain lesions and their correlative relations with the integral Glasgow Coma Scale (GCS) and National...
Source: Journal of Molecular Neuroscience - April 28, 2020 Category: Neuroscience Source Type: research

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

Risk of Spontaneous Intracranial Hemorrhage in HIV-infected Individuals: A Population-based Cohort Study
Background: We studied the association between HIV infection, antiretroviral medications, and the risk of spontaneous intracranial hemorrhage.Methods: We performed a cohort and nested case control study in an administrative database. We selected all HIV-positive individuals presenting between 1985 and 2007. Each HIV-positive subject was matched with 4 HIV-negative individuals. We used a Poisson regression model to calculate rates of intracranial hemorrhage according to HIV status. We conducted a case -control study nested within the cohort of HIV-positive individuals to look at the effect of antiretroviral medications. Odd...
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2012 Category: Neurology Authors: Madeleine Durand, Odile Sheehy, Jean-Guy Baril, Jacques LeLorier, Cécile L. Tremblay Tags: Original Articles Source Type: research

Rehabilitation Improves Behavioral Recovery and Lessens Cell Death Without Affecting Iron, Ferritin, Transferrin, or Inflammation After Intracerebral Hemorrhage in Rats
Conclusions. Rehabilitation is an effective behavioral and neuroprotective strategy for ICH. Neither effect appears to stem from influencing iron toxicity or inflammation. Thus, additional work must identify underlying mechanisms to help further therapeutic gains.
Source: Neurorehabilitation and Neural Repair - April 14, 2014 Category: Neurology Authors: Caliaperumal, J., Colbourne, F. Tags: Basic Research Article Source Type: research

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