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Condition: Hemorrhagic Stroke
Management: National Institutes of Health (NIH)

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Total 163 results found since Jan 2013.

Systolic Blood Pressure Variability is Associated with Severe Hemorrhagic Transformation in the Early Stage After Thrombolysis
Abstract The present study investigates the association between hour-to-hour blood pressure (BP) variability and severe hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) during hyperacute stage. We analyzed hour-to-hour BP measurement within 24 h after IVT in patients with acute ischemic stroke. We calculated the maximum, minimum, and average (mean) of 24-h BP values, and BP variability profiles including standard deviation (SD), average squared difference between successive measurements (SV), average squared difference between rise and drop successive measurements (SV rise and SV drop), and ma...
Source: Translational Stroke Research - February 19, 2016 Category: Neurology Source Type: research

Higher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
Abstract Insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke. We investigated whether there is a relationship between insulin resistance and clinical findings and outcomes of acute ischemic stroke patients treated with intravenous thrombolysis. In our study, 180 acute ischemic stroke non-diabetic patients treated with intravenous recombinant tissue-type plasminogen activator (iv rt-PA) were evaluated for insulin resistance assessed by homeostasis model assessment insulin resistance (HOMA-IR). The threshold for HOMA-IR was determined as 2.7. Patients were grouped as HOMA-IR > 2...
Source: Translational Stroke Research - January 30, 2016 Category: Neurology Source Type: research

Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients
Abstract Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified consecutive adult CVT patients treated at the Helsinki University Hospital (1987–2013) and invited them to a follow-up visit. Each clinical examination was combined with interview. We also recorded recurrent venous thromboembolism (VTE) and hemorrhagic events during follow-up and antithrombo...
Source: Journal of Neurology - January 2, 2016 Category: Neurology Source Type: research

Elevation in circulating YKL-40 concentration in patients with cerebrovascular disease.
Authors: Xu X, Ma H, Xu J, Huang H, Wu X, Xiong Y, Zhan H, Huang F Abstract YKL-40 is a novel inflammatory protein. Elevated serum levels of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases, but the circulating profile of YKL-40 in patients with cerebrovascular disease has been less investigated. This prospective observational study aimed to determine serum levels of YKL-40 in patients with different subtypes and severities of cerebrovascular disease. Eighty patients with acute ischemic stroke, 30 patients with acute hemorrhagic stroke, 15 patients with transient ischemic...
Source: Bosnian Journal of Basic Medical Sciences - December 20, 2015 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research

Brain-heart axis - Review Article.
Authors: Manea MM, Comsa M, Minca A, Dragos D, Popa C Abstract UNLABELLED: There has been a large confirmation over the last decades that stroke may produce cardiac changes (echocardiographic, electrocardiographic, enzymatic). In ischemic stroke, systolic dysfunction is associated with a high risk of mortality during hospitalization. A recent study demonstrated that cardiac diastolic dysfunction could also accompany acute stroke besides the systolic dysfunction already pointed out by previous studies, being a predictive marker of acute cerebrovascular events. Increased sympathetic activity is contributory, inducing...
Source: Journal of Medicine and Life - November 18, 2015 Category: Journals (General) Tags: J Med Life Source Type: research

Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage
Abstract: The authors evaluated neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B), and heat shock protein 70 (HSP 70) levels and their relationships with in-hospital mortality, Glasgow Coma Scale (GCS) scores, and National Institute of Health Stroke Scale (NIHSS) scores. In total, 35 patients older than 18 years were presented to our emergency department and were diagnosed with non-traumatic intracranial hemorrhage (ICH) and 32 healthy controls were included. Blood samples were drawn on days 0 and 5. S100 calcium-binding protein B and HSP levels were significantly higher in patients than in controls on ...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Treatment of Rivaroxaban versus Aspirin for Non-disabling Cerebrovascular Events (TRACE): study protocol for a randomized controlled trial
DiscussionEven though the new oral anticoagulants seem to be both safe and effective, few clinical trials have been carried out to test their effect on non-disabling cerebrovascular events. Treatment with rivaroxaban may prevent more cerebrovascular events with an acceptable risk profile after TIA or minor stroke, compared with aspirin, thus helping to improve the outcome of the disease.Trial registrationNo. NCT01923818
Source: BMC Neurology - October 12, 2015 Category: Neurology Authors: Fang YangWenrui JiangYa BaiJunliang HanXuedong LiuGuangyun ZhangGang Zhao Source Type: research

Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study
Background: The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development. Methods: Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanali...
Source: BMC Neurology - October 7, 2015 Category: Neurology Authors: David WangLeonid ChurilovRichard DowlingPeter MitchellBernard Yan Source Type: research

Current trends in the management of acute ischemic stroke
Srinivasan ParamasivamNeurology India 2015 63(5):665-672Stroke is the leading cause of disability and most of the cases are those of ischemic stroke. Management strategies especially for large vessel occlusive stroke have undergone a significant change in the recent years that include widespread use of thrombolytic medications followed by endovascular clot removal. For successful treatment by endovascular thrombectomy, the important factors are patient selection based on clinical criterion including age, time of onset, premorbid clinical condition, co-morbidities, National Institute of Health Stroke Scale, and imaging crit...
Source: Neurology India - October 6, 2015 Category: Neurology Authors: Srinivasan Paramasivam Source Type: research

Predictors of 30-Day Hospital Readmission Following Ischemic and Hemorrhagic Stroke
Stroke patients have a high rate of 30-day readmission. Understanding the characteristics of patients at high risk of readmission is critical. A retrospective case-control study was designed to determine factors associated with 30-day readmission after stroke. A total of 79 cases with acute ischemic or hemorrhagic strokes readmitted to the same hospital within 30 days were compared with 86 frequency-matched controls. Readmitted patients were more likely to have had ≥2 hospitalizations in the year prior to stroke (21.5% vs 2.3% in controls, P < .001), and in the multivariate model, admission National Institutes of Hea...
Source: American Journal of Medical Quality - August 24, 2015 Category: Health Management Authors: Strowd, R. E., Wise, S. M., Umesi, U. N., Bishop, L., Craig, J., Lefkowitz, D., Reynolds, P. S., Tegeler, C., Arnan, M., Duncan, P. W., Bushnell, C. D. Tags: Articles Source Type: research

The use of serum glial fibrillary acidic protein test as a promising tool for intracerebral hemorrhage diagnosis in Chinese patients and prediction of the short-term functional outcomes
The objective of this study was to explore the efficacy of glial fibrillary acidic protein (GFAP) in differentiating intracerebral hemorrhage (ICH) from ischemic stroke (IS). Suspicious patients of acute stroke were screened and finally diagnosed by computed tomography and magnetic resonance imaging. Blood samples were collected within 2–6 h after onset of symptoms, and serum GFAP level was determined by ELISA assay. The functional outcome for the patients was determined by modified Rankin Scale (mRS) 90 days after onset of symptoms. 43 ICH patients and 65 IS patients were enrolled. GFAP concentration in ICH group was ...
Source: Neurological Sciences - July 21, 2015 Category: Neurology Source Type: research

Ultrastructural Changes of Brain Tissues Surrounding Hematomas after Intracerebral Hemorrhage
In this study, cerebral ultrastructure surrounding hematoma and its correlation with clinical severity were investigated in ICH patients. Thirty patients with basal ganglia hemorrhage and 6 control subjects were enrolled. Surgical evacuation was performed for patients with a blood loss>30 ml. Stroke severity was assessed using the Glasgow Coma Scale (GCS) and the National Institute of Health Stroke Scale (NIHSS). Transmission electron microscopy (TEM) was used to evaluate the ultrastructural characteristics of tissue specimens. Neural cells surrounding the hematomas showed evidence of cell swelling and necrosis. Decreased ...
Source: European Neurology - July 1, 2015 Category: Neurology Source Type: research

Joni Mitchell's Aneurysm, Explained
Musician Joni Mitchell is recovering from an aneurysm she suffered in March, according to a statement from her conservator, Leslie Morris. Contrary to rumors about her condition, Mitchell can speak, and is going through therapy to help regain the ability to walk again, Morris wrote. Few details have been given about Mitchell’s aneurysm, except that she was found unconscious in her Bel Air home on March 31 and immediately transported to a Los Angeles-area hospital in an ambulance. She’s now resting at home, according to Morris’ latest statement, and a full recovery is expected. Aneurysms are a condition in which th...
Source: Science - The Huffington Post - June 30, 2015 Category: Science Source Type: news

Thrombectomy in patients ineligible for iv tPA (THRILL)
DiscussionWhether mechanical thrombectomy in patients with acute ischemic stroke who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator improves clinical outcomes is unclear. ‘Thrombectomy in patients ineligible for iv tPA’ may change clinical practice by providing evidence of an effective and safe treatment for such patients.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Martin Bendszus, Götz Thomalla, Michael Knauth, Werner Hacke, Susanne Bonekamp, Jens Fiehler Tags: Protocol Source Type: research

Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage
Abstract Iron plays a detrimental role in the intracerebral hemorrhage (ICH)-induced brain damage, while hepcidin is the most important iron-regulated hormone. Here, we investigate the association between serum hepcidin and serum iron, outcome in patients with ICH. Serum samples of 81 cases with ICH were obtained on consecutive days to detect the levels of hepcidin, iron, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The National Institutes of Health Stroke Scale score (NIHSS) was measured at admission and on days 7 and 30, and the modified Rankin Scale (mRS) score was evaluated at 3 months after IC...
Source: Neurological Sciences - May 30, 2015 Category: Neurology Source Type: research