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Condition: Hemorrhagic Stroke
Management: National Institutes of Health (NIH)

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Total 163 results found since Jan 2013.

E-065 Experience with neuroform atlas stenting as rescue endovascular treatment after failed mechanical thrombectomy secondary to intracranial atherosclerosis
ConclusionsOur series provides preliminary safety and efficacy data regarding the use of the Neuroform Atlas stent as a rescue modality in ICAS-ELVO cases.Disclosures O. Lajthia: None. E. Almallouhi: None. K. Kicielinski: None. J. Lena: None. A. Spiotta: None. S. Al Kasab: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lajthia, O., Almallouhi, E., Kicielinski, K., Lena, J., Spiotta, A., Al Kasab, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Acute Stroke Diagnosis
Am Fam Physician. 2022 Jun 1;105(6):616-624.ABSTRACTStroke accounts for significant morbidity and mortality and is the fifth leading cause of death in the United States, with direct and indirect costs of more than $100 billion annually. Expedient recognition of acute neurologic deficits with appropriate history, physical examination, and glucose testing will help diagnose stroke and rule out mimicking presentations. The National Institutes of Health Stroke Scale should be used to determine stroke severity and to monitor for evolving changes in clinical presentation. Initial neuroimaging is used to differentiate between isc...
Source: American Family Physician - June 15, 2022 Category: Primary Care Authors: Edwin Y Choi Gilberto A Nieves Darrell Edward Jones Source Type: research

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial
AbstractRecombinant human prourokinase (rhPro-UK) is a novel thrombolytic that has been approved to treat patients with acute myocardial infarction. However, the safety and efficacy of intravenous rhPro-UK in patients with acute ischemic stroke (AIS) has not been well established. We aimed to investigate the safety and preliminary efficacy of rhPro-UK in patients with AIS in a multi-center phase IIa trial setting. One hundred nineteen patients within 4.5  h of AIS onset were enrolled in this randomized, open-label, 23-center phase IIa clinical trial. Patients were randomly assigned to 35 mg (n = 40) or 50 mg (n =â...
Source: Translational Stroke Research - May 3, 2022 Category: Neurology Source Type: research

Computed Tomography Images under Artificial Intelligence Algorithms on the Treatment Evaluation of Intracerebral Hemorrhage with Minimally Invasive Aspiration
Comput Math Methods Med. 2022 Apr 22;2022:6204089. doi: 10.1155/2022/6204089. eCollection 2022.ABSTRACTThe aim of this study was to investigate the therapeutic effect of minimally invasive aspiration on intracerebral hemorrhage (ICH) and the value of artificial intelligence algorithm combined with computed tomography (CT) image evaluation. Ninety-two patients with intracerebral hemorrhage were divided into experimental group (46 cases, minimally invasive aspiration therapy) and control group (46 cases, traditional craniotomy therapy) according to different treatment methods, and CT image scanning was performed. In addition...
Source: Computational and Mathematical Methods in Medicine - May 2, 2022 Category: Statistics Authors: Junfeng Sun Xiaojun Zheng Qiang Gao Xiaofeng Wang Yu Qiao Jialong Li Source Type: research

Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in patients with CVST, this study retrospectively evaluated the clinical data of patients diagnosed with CVST at two centers from January 2011 to December 2020 and analyzed the relationship between admission characteristics and early onset seizures. A total of 112 CVST patients (63 men and 49 women; mean age 39.82 ± 15.70 years) were...
Source: Frontiers in Neurology - March 29, 2022 Category: Neurology Source Type: research

National Institutes of Health Stroke Scale Correlates Well with Initial Intracerebral Hemorrhage Volume
The US Centers for Medicare and Medicaid Services (CMS) currently publicly reports hospital-quality, risk-adjusted mortality measure for ischemic stroke but not intracerebral hemorrhage (ICH). The NIHSS, which is captured in CMS administrative claims data, is a candidate metric for use in ICH risk adjustment and has been shown to predict clinical outcome with accuracy similar to the ICH Score. Correlation between early NIHSS and initial ICH volume would further support use of the NIHSS for ICH risk adjustment.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2022 Category: Neurology Authors: Salman Farooq, Kristina Shkirkova, Pablo Villablanca, Nerses Sanossian, David S. Liebeskind, Sidney Starkman, Gilda Avila, Latisha Sharma, May Kim-Tenser, Suzie Gasparian, Marc Eckstein, Robin Conwit, Scott Hamilton, Jeffrey L. Saver Tags: Original Article Source Type: research

FLAIR vascular hyperintensity predicts early neurological deterioration in patients with acute ischemic stroke receiving endovascular thrombectomy
AbstractFluid-attenuated inversion recovery vascular hyperintensity (FVH) is frequently observed in patients with acute ischemic stroke (AIS). FVH is associated with functional outcome at 3  months in AIS patients receiving endovascular thrombectomy. In the present study, we assessed whether FVH predicted early neurological deterioration (END) and hemorrhagic transformation (HT) within 72 h in AIS patients receiving endovascular thrombectomy. We retrospectively analyzed 104 patients with acute internal-carotid-artery or proximal middle-cerebral-artery occlusion within 16 h after symptom onset. Before thrombectomy, all p...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Outcomes and risk factors of perforating and non-perforating middle cerebral artery infarctions after intravenous thrombolysis
AbstractThe clinical symptoms of perforating arteries differ, and responses to intravenous thrombolytic therapy are heterogeneous. Here, we investigated the effect of intravenous thrombolytic therapy and the related factors influencing acute perforating and non-perforating middle cerebral artery infarctions. We analyzed 320 patients with acute middle cerebral artery infarction who received alteplase thrombolysis within 4.5  h of onset at two stroke centers from January 2016 to December 2019. Outcome measures included rates of a favorable functional outcome (modified Rankin Scale scores of 0–2), distribution of modified ...
Source: Journal of Thrombosis and Thrombolysis - January 14, 2022 Category: Hematology Source Type: research

Proteomics-Based Approach to Identify Novel Blood Biomarker Candidates for Differentiating Intracerebral Hemorrhage From Ischemic Stroke —A Pilot Study
Discussion: In this exploratory proteomics-based pilot study, nine candidate biomarkers for differentiation of IS and ICH were identified. The proteins belong to the immune system, the coagulation cascade, and the apoptosis system, respectively. Further investigations in larger cohorts of patients with stroke using additional biochemical analysis methods, such as ELISA or Western Blotting are now necessary to validate these markers, and to characterize diagnostic accuracy with regard to the development of a point-of-care-system for use in resource-limited areas.
Source: Frontiers in Neurology - December 17, 2021 Category: Neurology Source Type: research

Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
In most patients with intracerebral hemorrhage (ICH), the hematoma and perihematomal area decrease over the subsequent months but patients continue to exhibit neurological impairments. In this serial imaging study, we characterized microstructural and neurophysiological changes in the ICH-affected brain tissues and collected the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Score (mRS), two clinical stroke scale scores. Twelve ICH patients were serially imaged on a 3T MRI at 1, 3, and 12 months (M) after injury. The hematoma and perihematomal volume masks were created and segmented using FLAIR imagi...
Source: Frontiers in Neurology - November 30, 2021 Category: Neurology Source Type: research

Effect of Danhong injection on neurological recovery and adverse events in patients with acute ischemic stroke: A protocol for a randomized, double-blind, placebo-controlled clinical study
This study will evaluate the effect of Danhong injection on neurological recovery and AEs in AIS. The results will provide a reference for the clinical use of AIS.
Source: Medicine - November 19, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Letter to the editor regarding ‘prediction of intracerebral hemorrhage after endovascular treatment of acute ischemic stroke: Combining quantitative parameters on dual-energy CT with clinical related factors’
This study recruited 72 acute ischemic stroke patients treated with endovascular treatment, forty of whom developed intracerebral hemorrhage (ICH). According to the results of receiver operating characteristic curve and multivariate logistic regression analysis, the authors have found that hyperdensity areas (HDA) volumes, alberta stroke program early CT score (ASPECTS), National Institutes of Health Stroke Scale (NIHSS) score and some other parameters may be related to and be able to predict ICH after endovascular treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2021 Category: Neurology Authors: Meidi Peng, Yachi Gong, Yupei Chen, Wenxuan Zhao Tags: Letter to the Editor Source Type: research

Predictors of hemorrhagic complications after intravenous thrombolysis in acute cerebral infarction patients: A single-center study of 391 cases
This study aimed to analyze the risk factors of hemorrhagic complications after intravenous thrombolysis using Urokinase in acute cerebral infarction (ACI) patients. Total 391 consecutive ACI patients were enrolled and divided into 2 groups: the hemorrhagic complications group and the non-hemorrhagic complications group. The related data were collected and analyzed. Univariate analysis showed significant differences in prothrombin time, atrial fibrillation (AF), Mean platelet volume, large platelet ratio (L-PLR), triglyceride (TG), Lactate dehydrogenase, alanine aminotransferase (ALT), high-density lipoprotein, and b...
Source: Medicine - September 17, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research