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Condition: Rheumatoid Arthritis

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Total 493 results found since Jan 2013.

Prevention of Stroke in Rheumatoid Arthritis
Abstract The risk of cerebrovascular disease is increased among rheumatoid arthritis (RA) patients and remains an underserved area of medical need. Only a minor proportion of RA patients achieve suitable stroke prevention. Classical cardiovascular risk factors appear to be under-diagnosed and undertreated among patients with RA. Reducing the inflammatory burden is also necessary to lower the cardiovascular risk. An adequate control of disease activity and cerebrovascular risk assessment using national guidelines should be recommended for all patients with RA. For patients with a documented history of cerebrovascu...
Source: Current Neurology and Neuroscience Reports - October 20, 2015 Category: Neuroscience Source Type: research

Drug used to treat arthritis could save stroke patients
British doctors are trialling the use of a rheumatoid arthritis drug which targets the inflammatory process in the brain caused by stroke in the same way it treats inflammation in an arthritic joint.
Source: the Mail online | Health - February 18, 2017 Category: Consumer Health News Source Type: news

Embolic Stroke due to Carotidynia Potentially Associated with Moving Carotid Artery Caused by Swallowing
A 63-year-old woman with end-stage renal disease on maintenance hemodialysis discontinued her medication for rheumatoid arthritis with prednisolone and azathioprine. One month later, she was admitted because of consciousness disturbance and right hemiparesis. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed multiple hyperintensities in her left frontal and parietal lobes. She also developed high fever and left neck pain. Carotid ultrasonography showed calcified plaque with vessel wall swelling at the bifurcation of the left common carotid artery (LCCA) and surrounding hypoechoic soft tissue.
Source: Journal of Stroke and Cerebrovascular Diseases - November 15, 2017 Category: Neurology Authors: Yoshitaka Yamaguchi, Mikito Hayakawa, Naoto Kinoshita, Chiaki Yokota, Toshiya Ishihara, Kazunori Toyoda Tags: Case Studies Source Type: research

Study: Drug reduces inflammation in early stroke symptoms
An anti-inflammatory drug approved to treat rheumatoid arthritis helped reduce inflammation in people in the early stages of stroke, according to new research.
Source: Health News - UPI.com - March 26, 2018 Category: Consumer Health News Source Type: news

Rheumatoid arthritis drug may reduce inflammation after stroke
The pro-inflammatory cytokine interleukin-1 plays a significant role in brain injury following ischemic stroke by inducing peripheral inflammatory mediators, such as interleukin-6. However, pre-clinical studies show its effects are reduced by the interleukin-1 receptor antagonist.
Source: Clinical Pharmacist - May 14, 2018 Category: Drugs & Pharmacology Source Type: research

Rheumatoid meningitis presenting with a stroke-like attack treated with recombinant tissue plasminogen activator: a case presentation
Rheumatoid meningitis presenting with a stroke-like attack (RMSA) is a rare manifestation of rheumatoid arthritis (RA). When the patients arrive within the time-window for recombinant tissue plasminogen activa...
Source: BMC Neurology - September 6, 2018 Category: Neurology Authors: Masashi Akamatsu, Futaba Maki, Hisanao Akiyama, Daisuke Hara, Masashi Hoshino and Yasuhiro Hasegawa Tags: Case report Source Type: research

WHO updates its essential medicines list, adds cancer and stroke drugs
The World Health Organization published an updated list of "essential medicines" on Tuesday, adding drugs for cancer, stroke, rheumatoid arthritis and inflammatory bowel disease among the treatments that should be seen as the standard.
Source: Reuters: Health - July 9, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

An Embolic Stroke in a Patient With PROC p.Lys193del
We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis
We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence ...
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Association of hyperlipidaemia, inflammation and serological status and coronary heart disease among patients with rheumatoid arthritis: data from the National Veterans Health Administration
Conclusions In this predominantly older male RA cohort, there was no clear association between LDL-C and CHD, whereas higher HDL-C was inversely associated with MI and stroke. CRP and ESR were similarly associated with increase MI risk and stroke, reflecting the prominent role of inflammation in CHD risk in RA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Navarro-Millan, I., Yang, S., DuVall, S. L., Chen, L., Baddley, J., Cannon, G. W., Delzell, E. S., Zhang, J., Safford, M. M., Patkar, N. M., Mikuls, T. R., Singh, J. A., Curtis, J. R. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Making use of equity sensitive QALYs: a case study on identifying the worse off across diseases
Conclusion: This study shows that it is feasible to identify who are the worse off empirically by the application of lifetime QALYs and proportional shortfalls. These methods ease further examination of whether there is a true conflict between maximization and equity or whether these two concerns actually coincide in real world cases. It is yet to be solved whether proportional prospective health losses are more important than absolute shortfalls in expected lifetime health in judgements about who are worse off.
Source: Cost Effectiveness and Resource Allocation - July 23, 2014 Category: Health Management Authors: Frode LindemarkOle NorheimKjell Johansson Source Type: research

One in 10 men aged 50 'have the heart of a 60-year-old'
"One-tenth of 50-year-old men have a heart age 10 years older than they are," BBC News reports. This is the finding of an analysis of 1.2 million people who used the NHS Heart Age Test. The principle behind the test is that you can "age" your heart through unhealthy behaviour such as smoking and being obese. Underlying conditions like high blood pressure and high cholesterol, which often have no noticeable symptoms, can also age the heart. An obese smoker in their 50s who has high blood pressure and high cholesterol could have the heart of a 60- or 70-year-old. The quick and simple test tells you the...
Source: NHS News Feed - September 4, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Rheumatoid arthritis and the risk of major cardiometabolic diseases: a Mendelian randomization study
CONCLUSION: Genetically determined RA was associated with increased risks of T2D and CAD, suggesting that RA plays a crucial role in the pathogenesis of T2D and CAD.PMID:35658786 | DOI:10.1080/03009742.2022.2070988
Source: Scandinavian Journal of Rheumatology - June 6, 2022 Category: Rheumatology Authors: K Zhang Y Jia R Wang D Guo P Yang L Sun Y Wang F Liu Y Zang M Shi Y Zhang Z Zhu Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Use of E-Selectin Tolerization as Treatment for Immunological and Vascular-Related Disorders
This technology relates to the mucosal delivery (e.g. intranasal) of an E-selectin fragment as a tolerization agent for the prevention and treatment of immunological and vascular-related disorders, including stroke and multiple sclerosis (MS) as well as rare or orphan diseases involving vascular modulated disorders. E-selectin is an adhesion molecule that is expressed on endothelial cells lining blood vessels in response to certain localized cytokines, making the endothelial surface pro-coagulant, pro-inflammatory and/or immunoreactive. Such changes on the endothelial surface have been linked to the development of vascula...
Source: NIH OTT Licensing Opportunities - April 1, 2001 Category: Research Authors: admin Source Type: research