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Total 50 results found since Jan 2013.

Natalizumab Versus Placebo in Patients with Acute Ischemic Stroke (AIS): Results from ACTION, a Multicenter, Double-Blind, Placebo-Controlled, Randomized Phase 2 Clinical Trial (S7.005)
CONCLUSIONS: A single dose of natalizumab administered up to 9 hours after stroke onset did not reduce focal infarct volume growth, but natalizumab appeared to be associated with important functional outcome improvements sustained over 90 days. Further natalizumab studies for AIS are warranted. Support: Biogen.Disclosure: Dr. Elkins holds stock and/or stock options in Biogen, which sponsored research in which Dr. Elkins was involved as a researcher. Dr. Elkind has received personal compensation in and editorial capacity for serving as an Associate Editor of the journal Neurology. Dr. Veltkamp has received research support ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Elkins, J., Elkind, M., Veltkamp, R., Montaner, J., Johnston, S., Singhal, A., Becker, K., Lansberg, M., Chang, I., Tang, W., Gheuens, S., Mehta, L. Tags: Stroke Clinical Trials Source Type: research

Prevalence and Predictors of Stroke in Patients with Crohn's Disease: A Nationwide Study
Mounting evidence points to the microbiome as a susceptibility factor for neurological disorders. Patients with Crohn's disease (CD) are at higher ischemic stroke (IS) risk, but no large scale epidemiologic studies have identified risk factors for stroke in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: Satvir Saggi, Alain Lekoubou, Bruce Ovbiagele Source Type: research

Inflammatory Bowel Disease as a Precondition for Stroke or TIA: A Matter of Crohn's Disease Rather than Ulcerative Colitis
As a chronic systemic inflammation may be associated with an increased risk of vascular events, the aim of the present study was to assess the incidence of stroke and transient ischemic attack (TIA) in patients with inflammatory bowel disease over a period of 15 years.
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Christian Tanislav, Kathleen Trommer, Christian Labenz, Karel Kostev Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Inflammatory bowel diseases increase future ischemic stroke risk: A Taiwanese population-based retrospective cohort study.
CONCLUSIONS: IBD exhibited an increased risk of developing ischemic stroke. PMID: 24906568 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 3, 2014 Category: Internal Medicine Authors: Huang WS, Tseng CH, Chen PC, Tsai CH, Lin CL, Sung FC, Kao CH Tags: Eur J Intern Med Source Type: research

Increased risk of stroke among patients with inflammatory bowel disease: A PRISMA ‐compliant meta‐analysis
ConclusionIBD is a risk factor for stroke. More high-quality large-sample epidemiologic studies about the relationship between IBD and stroke should be further conducted.
Source: Brain and Behavior - May 7, 2021 Category: Neurology Authors: Yao Chen, Xiang Wang Tags: REVIEW Source Type: research

Prevalence and Predictors of Stroke in Patients with Crohn's Disease: A Nationwide Study
CONCLUSION: A subset of traditional stroke risk factors are associated with IS in patients with CD. CD patients with these conditions could be targeted for vascular risk reduction and surveillance.PMID:34923435 | DOI:10.1016/j.jstrokecerebrovasdis.2021.106258
Source: Atherosclerosis - December 19, 2021 Category: Cardiology Authors: Satvir Saggi Alain Lekoubou Bruce Ovbiagele Source Type: research

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke: A Population-Based Cohort Study.
CONCLUSIONS: -The risk of cardiovascular diseases and T2DM is increased across a range of organ-specific and multi-system chronic inflammatory disorders with evidence that risk is associated with severity of inflammation. Clinical management of patients with chronic inflammatory disorders should aim to reduce cardiovascular risk. PMID: 24970784 [PubMed - as supplied by publisher]
Source: Circulation - June 26, 2014 Category: Cardiology Authors: Dregan A, Charlton J, Chowienczyk P, Gulliford MC Tags: Circulation Source Type: research

IBD sufferers at higher risk of stroke and heart attack
New research from the Mayo Clinic shows an increased risk of stroke or heart attack for patients with inflammatory bowel disease. Crohn's disease and ulcerative colitis are the most common forms of inflammatory bowel disease (IBD), according to the Centers for Disease Control and Prevention (CDC). In this disease, an abnormal response from the body's immune system mistakes food for a foreign substance, which triggers an immune response whereby the body attacks the cells lining the intestines, causing inflammation of the gastrointestinal tract...
Source: Health News from Medical News Today - October 16, 2013 Category: Consumer Health News Tags: Crohn's / IBD Source Type: news

Huge Free-Floating Thrombus in the Internal Carotid Artery
A 70-year-old male patient presented with very short recurrent speech difficulty and left-sided monocular transient visual loss. The patient was diagnosed with Crohn's disease and had hemicolectomy due to obstruction 10 years ago. He also had a history of coronary artery disease, hypertension, left femoral vein thrombosis, and 50-pack-year smoking. He had no stroke attack before. He was taking regularly dual antiplatelet therapy and azathioprine.
Source: Journal of Stroke and Cerebrovascular Diseases - August 22, 2017 Category: Neurology Authors: Uygur Tanriverdi, Osman Kizilkilic, Birsen Ince Tags: Letter to the Editor Source Type: research

Paradoxical Cerebral Embolism after Gastrointestinal Endoscopy in a Patient with Crohn's Disease
We describe a patient with Crohn's disease who developed paradoxical cerebral embolism after GE. Both an unstable venous thrombus in the superior vena cava and RLS through patent foramen ovale were thought to be responsible for the stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 28, 2018 Category: Neurology Authors: Hajime Ikenouchi, Naoto Sugeno, Takaaki Nakamura, Junpei Kobayashi, Ryuji Oshima, Hiroshi Kuroda, Masashi Aoki Tags: Case Studies Source Type: research

Inflammatory bowel disease and cardiovascular diseases
Inflammatory Bowel Disease is comprised of two major subtypes: Crohn's disease and ulcerative colitis, characterized by chronic inflammation of the gastrointestinal tract with extraintestinal manifestations that can involve a number of systems.1 There were estimated to be 7 million cases of inflammatory bowel disease globally in 2017, and at the national level, the United States had the highest age-standardized prevalence rate (464.5 per 100,000 population) of inflammatory bowel disease.2 Atherosclerotic cardiovascular diseases is defined as a history of acute coronary syndrome, myocardial infarction, stable or unstable an...
Source: The American Journal of Medicine - September 1, 2022 Category: General Medicine Authors: Bing Chen, Lauren V Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Edward V. Loftus, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J Lavie, Chayakrit Krittanawong Tags: Clinical Research Study Source Type: research

Treatment Of Panx1-Related Diseases Could Involve Food Dye
The food dye Brilliant Blue FCF (BB FCF) could be a useful tool in the development of treatments for a variety of conditions involving the membrane channel protein Pannexin 1(Panx1), according to a study in The Journal of General Physiology. Panx1, which is involved in signaling events leading to inflammation and cell death, has been implicated in such diverse diseases as Crohn's, AIDS, melanoma, epilepsy, spinal cord injury, and stroke, among others. Thus, there is a demand for the development of pharmacological tools to inhibit Panx1...
Source: Health News from Medical News Today - May 1, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Stem cells: what happened to the radical breakthroughs?
Much was promised in the late 1990s, but the challenge of advances such as growing whole human organs has been difficult to deliverIt's 1998 and science is taking big strides. The first cloned mammal, Dolly the Sheep, has just had her first lamb; the first robotically assisted heart surgery has been completed; Furbys have hit the shelves. In a bold announcement, biomedical engineer Professor Michael Sefton declared that within 10 years, scientists would have grown an entire heart, fit for transplant. "We're shooting big," he said. "Our vision is that we'll be able to pop out a damaged heart and replace it as easily as you ...
Source: Guardian Unlimited Science - August 10, 2013 Category: Science Authors: Simon Roach Tags: Biology Medical research Features Stem cells The Observer Science Source Type: news