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Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature
We report 8 such cases (4 infants aged 7–36 weeks, 4 children aged 5–15 years). Four underwent ex vivo magnetic resonance neuroimaging, to assist in identification of subtle lesions related to vascular compromise. All infants were found unresponsive (3 in unsafe sleeping conditions); all but 1 had recent rhinitis and/or influenza-like illness (ILI) in the family; 1 had history of sickle cell disease. Ex vivo neuroimaging in 1 case revealed white matter (WM) signal hyperintensity and diffuse exaggeration of perivascular spaces, corresponding microscopically to WM mineralization. Neurohistology in the remaining 3 infants...
Source: Frontiers in Neurology - May 24, 2022 Category: Neurology Source Type: research

Syndemic Pandemic in Portugal: Social Inequality in Risk Factors Associated With COVID-19 Mortality
CONCLUSION: In 2019, we observed socioeconomic inequalities of high magnitude for the eight diseases with demonstrated link to COVID-19 mortality.PMID:35533082 | DOI:10.20344/amp.16031
Source: Acta Medica Portuguesa - May 9, 2022 Category: General Medicine Authors: Julian Perelman Source Type: research

Incidence of newly diagnosed diabetes after Covid-19
Conclusions/interpretationCovid-19 confers an increased risk for type 2 diabetes. If confirmed, these results support the active monitoring of glucose dysregulation after recovery from mild forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Graphical abstract
Source: Diabetologia - May 8, 2022 Category: Endocrinology Source Type: research

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19
Med Sci Monit. 2022 May 1;28:e937048. doi: 10.12659/MSM.937048.ABSTRACTThe consequences of SARS-CoV-2 infection include short-term, long-term, mild, and severe clinical symptoms. The cardiovascular system, including endothelial cells, vascular smooth muscle cells, and cardiac myocytes, are important targets for SARS-CoV-2. In February 2022, the findings from a large US cohort of individuals diagnosed with COVID-19 and two sets of control cohorts evaluated the risk and 12-month cardiovascular disease burden. Individuals who had COVID-19 had a 72% increased risk of heart failure, a 63% increased risk of myocardial infarction...
Source: Medical Science Monitor - May 1, 2022 Category: Research Authors: Dinah V Parums Source Type: research

Incidence of newly diagnosed diabetes after Covid-19
Conclusions/interpretationCovid-19 confers an increased risk for type 2 diabetes. If confirmed, these results support the active monitoring of glucose dysregulation after recovery from mild forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Graphical abstract
Source: Diabetologia - March 16, 2022 Category: Endocrinology Source Type: research

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
Lancet Respir Med. 2021 Jul 27:S2213-2600(21)00310-6. doi: 10.1016/S2213-2600(21)00310-6. Online ahead of print.ABSTRACTBACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.METHODS: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. We included peo...
Source: Respiratory Care - July 30, 2021 Category: Respiratory Medicine Authors: Christopher C Butler Ly-Mee Yu Jienchi Dorward Oghenekome Gbinigie Gail Hayward Benjamin R Saville Oliver Van Hecke Nicholas Berry Michelle A Detry Christina Saunders Mark Fitzgerald Victoria Harris Ratko Djukanovic Stephan Gadola John Kirkpatrick Simon d Source Type: research

Comorbidity status of deceased COVID-19 in-patients in Italy
CONCLUSION: In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.PMID:34169447 | DOI:10.1007/s40520-021-01914-y
Source: Aging Clinical and Experimental Research - June 25, 2021 Category: Geriatrics Authors: Davide Liborio Vetrano Clare Tazzeo Luigi Palmieri Alessandra Marengoni Alberto Zucchelli Cinzia Lo Noce Graziano Onder Italian National Institute of Health Covid-Mortality Group Source Type: research

Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
Conclusions Broad neurologic features were found in 12% patients with PIMS-TS. By 3-month follow-up, half of these surviving children had recovered fully without neurologic impairment. Significantly higher systemic inflammatory markers were identified in children with neurologic involvement and in those who had not recovered fully.
Source: Neurology Neuroimmunology and Neuroinflammation - April 13, 2021 Category: Neurology Authors: Sa, M., Mirza, L., Carter, M., Carlton Jones, L., Gowda, V., Handforth, J., Hedderly, T., Kenny, J., Lascelles, K., Lin, J.-P., Lumsden, D., McDougall, M., Miller, O., Rossor, T., Shivamurthy, V., Siddiqui, A., Singh, R., Tang, S., White, M., Byrne, S., L Tags: Childhood stroke, Encephalitis, Prognosis, All Neuropsychology/Behavior Article Source Type: research

Clinical Outcome of Acute Ischemic Strokes in Patients with COVID-19
Conclusion: In this study, patients with AIS infected by SARS-CoV-2 showed a poorer early outcome than COVID − ones. However, when compared to other factors, COVID-19 was not a significant predictor of poor outcome. Vascular morbidity and mortality rates were significantly higher in the COVID+ group compared with the COVID− group.Cerebrovasc Dis
Source: Cerebrovascular Diseases - March 30, 2021 Category: Neurology Source Type: research

Excess mortality due to COVID-19 in Germany
SARS-CoV-2 is transmitted by droplets and likely aerosols. The median incubation period is about 5-6 days (range 1-14 days)1 and the median age at confirmed infection in Germany is 49 years. Typical symptoms include fever, cough, anosmia, ageusia, and pneumonia. The mortality rate of COVID-19 is higher among elderly and among ethnicities other than Caucasians. Furthermore, a markedly higher mortality rate has been observed for several comorbidities including obesity class II (BMI 35 •0-39•9 kg/m2) and III (BMI 40•0+ kg/m2), uncontrolled diabetes mellitus, malignancies in the previous year, severely reduced glomerular...
Source: Journal of Infection - September 17, 2020 Category: Infectious Diseases Authors: Andreas Stang, Fabian Standl, Bernd Kowall, Bastian Brune, Juliane B öttcher, Marcus Brinkmann, Ulf Dittmer, Karl-Heinz Jöckel Source Type: research

Coagulopathy and thromboembolic events in patients with SARS-CoV-2 infection: pathogenesis and management strategies
AbstractIn October 2019, a viral infectious disease appeared in the city of Wuhan in China. A new betacoronavirus, SARS-CoV-2, has been recognized as the responsible pathogen in this infection. Although coronavirus disease is principally expressed as a pulmonary infection, critical SARS-CoV-2 infection is frequently complicated with coagulopathy, and thromboembolic events are recognizable in several patients. Dehydration, acute inflammatory condition, protracted immobilization during disease, existence of multiple cardiovascular risk factors such as diabetes, obesity or hypertension, previous coronary artery disease, ische...
Source: Annals of Hematology - August 13, 2020 Category: Hematology Source Type: research

CDC Head Estimates U.S. Coronavirus Cases Might be 10 Times Higher Than Data Show
In a press briefing on June 25, Dr. Robert Redfield, director of the U.S. Centers for Disease Control and Prevention (CDC), said that the current official count of COVID-19 cases in the U.S. may actually be a drastic underestimate. Redfield said the new, much-higher estimate, is based on growing data from antibody testing, which picks up the presence of immune cells that react to SARS-CoV-2, the virus that causes COVID-19. People will test positive for antibodies to the virus if they have been infected—whether or not they ever got sick or even developed symptoms. Previously, testing was focused only on those with sym...
Source: TIME: Health - June 25, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

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