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Subsequent Vascular Events after Ischemic Stroke: The Japan Statin Treatment Against Recurrent Stroke—Longitudinal
We undertook a multicenter cohort observational study to investigate the frequency and type of subsequent vascular events after an ischemic stroke and to compare the rates of vascular events between patients with and without hyperlipidemia.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2014 Category: Neurology Authors: Eiichi Nomura, Akifumi Suzuki, Isao Inoue, Jyoji Nakagawara, Kazuo Takahashi, Tetsuya Takahashi, Yasuhiro Manabe, Chiaki Yokota, Kazunori Okada, Tetsuhiro Nishihara, Yasumasa Yamamoto, Koichi Noda, Shinichi Takahashi, Setsuro Ibayashi, Makoto Takagi, Kazu Source Type: research

The Effects of Previous Statin Treatment on Plasma Matrix Metalloproteinase-9 Level in Chinese Stroke Patients Undergoing Thrombolysis
It is unclear whether previous statin therapy influences the prognosis, hemorrhagic transformation, and plasma matrix metalloproteinases (MMP)-9 levels in Chinese stroke patients receiving intravenous thrombolysis. We conduct a prospective cohort study of 193 patients treated with intravenous thrombolysis. All the enrolled patients were divided into 2 groups (the control group and the statin group), according to the previous history of statin use. The plasma MMP-9 levels were detected before and at 6 hours, 12 hours, 24 hours, and 72 hours after intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2014 Category: Neurology Authors: Hong-Dong Zhao, Ying-Dong Zhang Source Type: research

Association of ATP-Binding Cassette Transporter G1 Polymorphisms with Risk of Ischemic Stroke in the Chinese Han Population
In this study, we investigate the association between ABCG1 polymorphisms and the risk of developing ischemic stroke in a Chinese Han population.
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2015 Category: Neurology Authors: Qu Li, Xu Liu, Ruixia Zhu, Zhiyi He Source Type: research

Inpatient Statin Use Is Associated with Decreased Mortality of Acute Stroke Patients with Very Low Low-Density Lipoprotein Cholesterol
To investigate the potential benefits of inpatient statin therapy on mortality of acute stroke patients with very low admission low-density lipoprotein cholesterol (LDL-C) level (
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Bo Song, Yilong Wang, Xingquan Zhao, Liping Liu, Chunxue Wang, Anxin Wang, Wanliang Du, Yongjun Wang, Yuming Xu Source Type: research

Statin Medication Use and Nosocomial Infection Risk in the Acute Phase of Stroke
Statins have immunomodulatory and peripheral anti-inflammatory properties that are independent of their lipid-lowering action. Whether these properties reduce the risk for developing poststroke infection is debated in clinical literature. We estimated the risk for developing nosocomial poststroke infection based on statin exposure in patients aged 18 or older hospitalized for ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 8, 2016 Category: Neurology Authors: Douglas L. Weeks, Christopher L. Greer, Megan N. Willson Source Type: research

Recurrent cryptogenic stroke in young adult linked to congenital left ventricular diverticulum
A 47-year-old man had an acute ischemic stroke (IS); brain MRI revealed multiple silent old IS (figure 1A). A comprehensive workup, including prolonged cardiac monitoring (cumulated duration of 25 days) and cardiac transthoracic/transesophageal echography, was negative. Eleven months later, despite statin and aspirin therapy, a new symptomatic embolic IS of undetermined source occurred (figure 1B). Cardiac MRI1 revealed a left apical dyskinetic saccular evagination (figure 2, A–C) consistent with a congenital left ventricular diverticulum confirmed on left ventriculography (figure 2D) and the presumed source of recur...
Source: Neurology - November 13, 2016 Category: Neurology Authors: Gaillard, N., Targosz, F., Bertrand, J. L., Sablot, D., Bensalah, Z. M. Tags: Stroke in young adults, Cardiac, Embolism, Infarction NEUROIMAGES Source Type: research

Dose-Dependent Effect of Statin Pretreatment on Preventing the Periprocedural Complications of Carotid Artery Stenting Clinical Sciences
Background and Purpose—We investigated whether statin pretreatment can dose dependently reduce periprocedural complications in patients undergoing carotid artery stenting because of symptomatic carotid artery stenosis.Methods—We enrolled a consecutive series of 397 symptomatic carotid artery stenosis (≥50% stenosis on conventional angiography) treated with carotid artery stenting at 2 tertiary university hospitals over a decade. Definition of periprocedural complications included any stroke, myocardial infarction, and death within 1 month after or during the procedure. Statin pretreatment was divided into 3 categorie...
Source: Stroke - June 26, 2017 Category: Neurology Authors: Jeong-Ho Hong, Sung-Il Sohn, Jaehyuk Kwak, Joonsang Yoo, Hyuk Won Chang, O-Ki Kwon, Cheolkyu Jung, Inyoung Chung, Hee-Joon Bae, Ji Sung Lee, Moon-Ku Han Tags: Stent, Ischemic Stroke Original Contributions Source Type: research

MRI scan that can predict stroke risk has 'promise to save lives'
Scientists at Oxford University develop non-invasive technique to measure amount of cholesterol in carotid plaquesA new type of MRI scan can predict the risk of having astroke, researchers have said in a study.The non-invasive technique, developed by scientists at the University of Oxford, predicts whether plaques in the carotid arteries are rich in cholesterol and therefore more likely to cause a stroke.Continue reading...
Source: Guardian Unlimited Science - August 23, 2017 Category: Science Authors: Haroon Siddique Tags: Stroke Society Health UK news Medical research Science Source Type: news

Statins for Neuroprotection After Acute Ischemic Stroke Editorial
Source: Stroke - October 23, 2017 Category: Neurology Authors: Peter Kelly, Shyam Prabhakaran Tags: Ischemic Stroke, Neuroprotectants Editorials Source Type: research

What Proportion of Patients Admitted with Stroke or Transient Ischemic Attack May Be Suitable for Newer Cholesterol-Lowering Treatment?
Protein convertase subtilisin –kexin type 9 (PCSK9) inhibitors effectively clear low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). We evaluated stroke admissions potentially eligible for more intensive cholesterol treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2019 Category: Neurology Authors: Vafa Alakbarzade, Anthony C. Pereira Source Type: research

Cost-Effectiveness of Using LDL-Direct Versus Lipid-Panel as Part of the Inpatient Stroke Workup
As part of the investigation for the etiology of ischemic stroke or transient ischemic attack, assessing for modifiable risk factors has become standard practice. One such risk factor is dyslipidemia. The current practice to assess for dyslipidemia is to obtain the low-density-lipoprotein cholesterol (LDL-C) through serology, either by ordering a lipid panel or by ordering a direct LDL in order to obtain a more precise measurement.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2020 Category: Neurology Authors: Richard Lane, Kunal Agrawal, Royya Modir Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research