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Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Co-Effect of Serum Galectin-3 and High-Density Lipoprotein Cholesterol on the Prognosis of Acute Ischemic Stroke
This study aimed to evaluate the coeffect of galectin-3 and HDL-C on death and vascular events within 1 year after ischemic stroke. Materials and Methods: Based on China Antihypertensive Trial in Acute Ischemic Stroke, a prospective study was conducted among 2970 patients with acute ischemic stroke. The primary outcome was a combination of death and vascular events within 1 year after ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2019 Category: Neurology Authors: Nimei Zeng, Aili Wang, Tan Xu, Chongke Zhong, Xiaowei Zheng, Zhengbao Zhu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He Source Type: research

Clinical Utility of the Inflammatory Factors Combined With Lipid Markers in the Diagnostic and Prognostic Assessment of Ischemic Stroke: Based on Logistic Regression Models
In this study, we developed novel logistic regression models for the diagnostic and prognostic assessment of ischemic stroke. Methods: A total of 288 ischemic stroke patients and 300 controls admitted to The First Affiliated Hospital of Soochow University were included in the testing group. Two validation groups from The Affiliated Kunshan Hospital of Jiangsu University and The Second Affiliated Hospital of Soochow University were included to assess our novel assessment models. Results: Results from the testing group indicated that the diagnostic assessment model for ischemic stroke prediction was: Logit(P)  = 437.116...
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2020 Category: Neurology Authors: Zhaoxi Ma, Yushan Yue, Yan Luo, Wanhua Wang, Yongjun Cao, Qi Fang Source Type: research

More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL & lt;70 mg/dL After a Stroke
CONCLUSIONS: In this post hoc analysis of the TST trial, targeting an LDL cholesterol of <70 mg/dL reduced the risk of primary outcome compared with 100±10 mg/dL provided LDL cholesterol reduction from baseline was superior to 50%, thereby suggesting that the magnitude of LDL cholesterol reduction was as important to consider as the target level to achieve.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01252875; https://clinicaltrialsregister.eu; Unique identifier: EUDRACT2009-A01280-57.PMID:37376989 | DOI:10.1161/STROKEAHA.123.042621
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Pierre Amarenco Philippa C Lavall ée Jong S Kim Julien Labreuche Hugo Charles Maurice Giroud Byung-Chul Lee Marie-H élène Mahagne Elena Meseguer Norbert Nighoghossian Philippe Gabriel Steg Éric Vicaut Eric Bruckert Treat Stroke to Target Investigators Source Type: research

Trends in Vascular Risk Factor Treatment and Control in US Stroke Survivors: The National Health and Nutrition Examination Surveys (1999-2010) Original Articles
Conclusions— Despite improvements in blood pressure treatment and control and cholesterol treatment for women and cholesterol treatment and control for men, stroke secondary prevention through treatment and control of vascular risk factors remains suboptimal. Urgent action is needed to improve secondary prevention to reduce stroke morbidity and mortality in this high-risk group.
Source: Circulation: Cardiovascular Quality and Outcomes - May 21, 2013 Category: Cardiology Authors: Shah, N. S., Huffman, M. D., Ning, H., Lloyd-Jones, D. M. Tags: Other Stroke Treatment - Medical Original Articles Source Type: research

Higher On-admission Serum Triglycerides Predict Less Severe Disability and Lower All-cause Mortality after Acute Ischemic Stroke
Conclusions: These data suggest that higher fasting TGs on-admission predict less severe disability, reduced disability progression, and all-cause mortality in patients with acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2012 Category: Neurology Authors: Slaven Pikija, Vladimir Trkulja, Lucija Juvan, Marija Ivanec, Dunja Dukši Tags: Original Articles Source Type: research

Trends in the Incidence of Stroke and Cardiovascular Risk Factors on the Isolated Island of Okinawa: The Miyakojima Study
Conclusions: In Miyakojima, the incidence of first-time stroke and all of its subtypes did not change significantly between two periods, even though blood pressure decreased significantly in the second period. Metabolic deterioration may be associated with the upward trend in incidence of brain infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2012 Category: Neurology Authors: Chikako Sugama, Katsunori Isa, Koichiro Okumura, Kunitoshi Iseki, Kozen Kinjo, Yusuke Ohya Tags: Original Articles Source Type: research

Long-term Adherence to National Guidelines for Secondary Prevention of Ischemic Stroke: A Prospective Cohort Study in a Public Hospital in Chile
Conclusions: The observed significant decrease in adherence to oral anticoagulation in patients with cardioembolic stroke suggests a need for the implementation of specific strategies to achieve the desired secondary prevention goals in these patients. Future research into the evaluation of other factors that could be associated with the lack of adherence to these guidelines, measurements of therapeutic goals, and new therapeutic strategies that are easier to use and that are associated with less risk could improve the prognosis of these patients.
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2013 Category: Neurology Authors: Paula Muñoz-Venturelli, Claudio Sacks, Eva Madrid, Pablo M. Lavados Tags: Original Articles Source Type: research

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals
Background: In young individuals, a genetically predisposing hypercoagulability and classic modifying risk factors can act synergistically on the ischemic stroke risk development. The aim of the study was to compare the prevalence of classic vascular risk factors and polymorphisms of the G20210A coagulation factor II (prothrombin), Arg506Glu coagulation factor V Leiden, C677T methylenetetrahydrofolate reductase (MTHFR), and 4G/5G plasminogen activator inhibitor-1 (PAI-1) and the impact of these gene mutations and classic vascular risk factors on the overall stroke risk in individuals aged 55 years or younger.Methods: The s...
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2013 Category: Neurology Authors: Visnja Supanc, Zdenko Sonicki, Ines Vukasovic, Vesna V. Solter, Iris Zavoreo, Vanja B. Kes Tags: Original Articles Source Type: research

Overenthusiastic stroke risk factor modification in the over-80s: Are we being disingenuous to ourselves, and to our oldest patients?
Statins and antihypertensive therapy are widely used in our oldest patients (ie, those aged over 80 years). The epidemiology suggests that, by this age, hypertension is not an attributable risk factor for stroke, and hypercholesterolaemia has little effect on stroke risk overall. The largest trials of antihypertensive therapy and statins in this age group show at best a marginal clinical reduction in stroke and very modest clinical reductions in other cardiovascular end points. Older patients have very diverse views on the relative importance of stroke and death as end points, and these differ from physicians’ views....
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Byatt, K. Tags: Geriatric medicine, Clinical trials (epidemiology), Editor's choice, Press releases, Drugs: cardiovascular system, Stroke, Hypertension, Ethics, Legal and forensic medicine, Lipid disorders Perspective Source Type: research

Burden of stroke in Puerto Rico
Stroke is the fifth leading cause of death and the first cause of long‐term disability in Puerto Rico. Trained staff reviewed and independently validated the medical records of patients who had been hospitalized with possible stroke at any of the 20 largest hospitals located in Puerto Rico during 2007, 2009, and 2011. The mean age of the 5005 newly diagnosed stroke patients (51·2% female) was 70 years. At the time of hospitalization, women were 4½ years older, were less likely to be married (60·2% vs. 39·9%, P < 0·001), smoked less (5·8% vs. 13·4%, P < 0·001), and had significantly higher proportion...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: J. C. Zevallos, F. Santiago, J. González, A. Rodríguez, L. Pericchi, R. Rodríguez‐Mercado, U. Nobo Tags: Panorama Source Type: research

More Than 8 Hours Of Sleep Linked To Increased Stroke Risk
BOSTON (CBS) – Could getting more than eight hours of sleep a night be a bad thing? Many of us are lucky to get that much, but if we do, Dr. Mallika Marshall says it might be a warning sign for stroke. The National Sleep Foundation says adults between the ages of 18 and 64 should get seven to nine hours of sleep a night, but a new study from the University of Cambridge looked at more than 9,000 middle-aged and older adults and found that those who slept for more than eight hours a night were 46% more likely to have a stroke over the nine and a half years than people who slept six to eight hours a night. It may be tha...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 26, 2015 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Dr. Mallika Marshall Sleep Stroke Source Type: news

Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes
Conclusions: AIS are missed in patients with younger age with a lower cerebrovascular risk profile and may be masked by other acute conditions. Patients with chameleons present more often with milder strokes or coma, fewer focal signs and cerebellar strokes, and have higher disability and mortality rates at 12 months. These findings may be used to raise awareness in emergency departments to recognize and treat such patients appropriately.
Source: Neurology - August 10, 2015 Category: Neurology Authors: Richoz, B., Hugli, O., Dami, F., Carron, P.-N., Faouzi, M., Michel, P. Tags: Other cerebrovascular disease/ Stroke, Natural history studies (prognosis), Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Association of Lp-PLA2-A and early recurrence of vascular events after TIA and minor stroke
Conclusions: Higher levels of Lp-PLA2-A in the acute period are associated with increased short-term risk of recurrent vascular events.
Source: Neurology - November 2, 2015 Category: Neurology Authors: Lin, J., Zheng, H., Cucchiara, B. L., Li, J., Zhao, X., Liang, X., Wang, C., Li, H., Mullen, M. T., Johnston, S. C., Wang, Y., Wang, Y., On behalf of the CHANCE investigators Tags: Other cerebrovascular disease/ Stroke ARTICLE Source Type: research

Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia Clinical Sciences
Conclusions— Adherence to the American Heart Association’s ideal CVH factors and behaviors, particularly in midlife, may protect against cerebrovascular disease and dementia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Pase, M. P., Beiser, A., Enserro, D., Xanthakis, V., Aparicio, H., Satizabal, C. L., Himali, J. J., Kase, C. S., Vasan, R. S., DeCarli, C., Seshadri, S. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Cognitive Impairment Clinical Sciences Source Type: research