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Discharge Is a Critical Time to Influence 10-Year Use of Secondary Prevention Therapies for Stroke Clinical Sciences
Conclusions— Prescription of medications at hospital discharge was the strongest predictor of ongoing medication use in survivors of stroke, even at 10 years after stroke. Ensuring that patients with stroke are discharged on optimal medications is likely to improve their long-term management, but further strategies might be required among those who are disadvantaged.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Thrift, A. G., Kim, J., Douzmanian, V., Gall, S. L., Arabshahi, S., Loh, M., Evans, R. G. Tags: Compliance/Adherence, Secondary prevention, Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Statins Improve Survival in Patients With Cardioembolic Stroke Brief Reports
Conclusions— Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Choi, J.-Y., Seo, W.-K., Kang, S. H., Jung, J.-M., Cho, K.-H., Yu, S., Oh, K. Tags: Cerebrovascular disease/stroke, Embolic stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Body Mass Index and Stroke Risk Among Patients With Type 2 Diabetes Mellitus Clinical Sciences
Conclusions— The present study demonstrates an inverse association between BMI and stroke risk among patients with type 2 diabetes mellitus.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Li, W., Katzmarzyk, P. T., Horswell, R., Zhang, Y., Zhao, W., Wang, Y., Johnson, J., Hu, G. Tags: Obesity, Type 2 diabetes, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Statin Adherence Is Associated With Reduced Recurrent Stroke Risk in Patients With or Without Atrial Fibrillation Clinical Sciences
Conclusions—The relationship between statin adherence and reduced recurrent stroke risk is as strong among patients with AFib as it is among patients without AFib, suggesting that AFib status should not be a reason to exclude patients from secondary stroke prevention with a statin.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Alexander C. Flint, Carol Conell, Xiushui Ren, Hooman Kamel, Sheila L. Chan, Vivek A. Rao, S. Claiborne Johnston Tags: Arrhythmias, Lipids and Cholesterol, Secondary Prevention, Ischemic Stroke Original Contributions Source Type: research

Moderate-to-vigorous physical activity and the risk of stroke recurrence in patients with a history of minor ischemic stroke in Japan: a retrospective analysis.
CONCLUSIONS: Patients with a history of mild ischemic stroke had low MVPA and high VFL values, which together may be a risk factor for RIS. PMID: 30207894 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 12, 2018 Category: Neurology Authors: Ushio M, Kanaoka M, Kinoshita Y, Maeno S, Fujita K Tags: Top Stroke Rehabil Source Type: research

The Effect of Medical Treatments on Stroke Risk in Asymptomatic Carotid Stenosis Brief Reports
Conclusions— Antiplatelet therapy and blood pressure control are the most important factors in reducing short-term stroke and cardiovascular risk in patients with asymptomatic carotid stenosis. More prospective data are required for medical treatments in asymptomatic carotid stenosis in particular for current statin usage.
Source: Stroke - January 18, 2013 Category: Neurology Authors: King, A., Shipley, M., Markus, H., for the ACES Investigators Tags: Carotid Stenosis, Risk Factors for Stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Sickle Cell Trait and Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— We observed an increased risk of ischemic stroke in blacks with SCT. Further investigation of the incidence and pathophysiology of stroke in patients with SCT is warranted.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Caughey, M. C., Loehr, L. R., Key, N. S., Derebail, V. K., Gottesman, R. F., Kshirsagar, A. V., Grove, M. L., Heiss, G. Tags: Genetics of Stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Fixed-Dose Combination Treatment After Stroke for Secondary Prevention in China: A National Community-Based Study Clinical Sciences
Conclusions— A huge number of stroke patients in China require preventive therapy and would be eligible for a polypill. This study indicates that it would be reasonable to consider and assess the value of a polypill strategy to improve secondary prevention of stroke in China.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Longde, W., Ling, Y., Yang, H., Yi, Z., Yongjun, W., Xunming, J., Xiaoyuan, N., Qiumin, Q., Li, H., Yuming, X., Mei, L., Jiayi, S., Jing, L., Dong, Z. Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Inflammatory Markers and Outcomes After Lacunar Stroke: Levels of Inflammatory Markers in Treatment of Stroke Study Clinical Sciences
Conclusions— Among recent lacunar stroke patients, IL-6 and TNF receptor concentrations predict risk of recurrent vascular events, and they are associated with the effect of antiplatelet therapies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Boehme, A. K., McClure, L. A., Zhang, Y., Luna, J. M., Del Brutto, O. H., Benavente, O. R., Elkind, M. S. V. Tags: Ischemic Stroke Clinical Sciences Source Type: research

Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke Clinical Sciences
Conclusions—After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo Tags: Secondary Prevention, Compliance/Adherence, Ischemic Stroke Original Contributions Source Type: research

Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials Original Contributions
Conclusion— In the largest meta-analysis to date, statin therapy at stroke onset was associated with improved outcome, a finding not observed in studies restricted to thrombolysis-treated patients. Randomized trials of statin therapy in acute ischemic stroke are needed.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Ni Chroinin, D., Asplund, K., Asberg, S., Callaly, E., Cuadrado-Godia, E., Diez-Tejedor, E., Di Napoli, M., Engelter, S. T., Furie, K. L., Giannopoulos, S., Gotto, A. M., Hannon, N., Jonsson, F., Kapral, M. K., Marti-Fabregas, J., Martinez-Sanchez, P., Mi Tags: Acute Cerebral Infarction, Neuroprotectors, Other Stroke Treatment - Medical Original Contributions Source Type: research

Life's Simple 7 and Risk of Incident Stroke: The Reasons for Geographic and Racial Differences in Stroke Study Clinical Sciences
Conclusions— In both blacks and whites, better cardiovascular health, on the basis of the LS7 score, is associated with lower risk of stroke, and a small difference in scores was an important stroke determinant.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Kulshreshtha, A., Vaccarino, V., Judd, S. E., Howard, V. J., McClellan, W. M., Muntner, P., Hong, Y., Safford, M. M., Goyal, A., Cushman, M. Tags: Behavioral Changes and Stroke, Epidemiology Clinical Sciences Source Type: research

Predictors of Stroke in Patients With Impaired Glucose Tolerance: Results From the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial Brief Reports
Conclusions— The most powerful predictors of stroke in patients with impaired glucose tolerance included a combination of established risk factors and novel variables, such as previous venous thromboembolism and elevated waist circumference, allowing moderately effective identification of high-risk individuals.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Preiss, D., Giles, T. D., Thomas, L. E., Sun, J.-L., Haffner, S. M., Holman, R. R., Standl, E., Mazzone, T., Rutten, G. E., Tognoni, G., Chiang, F.-T., McMurray, J. J. V., Califf, R. M. Tags: Cerebrovascular disease/stroke, Risk Factors, Glucose intolerance Brief Reports Source Type: research

Diabetes and stroke prevention: a review.
Authors: Hewitt J, Castilla Guerra L, Fernández-Moreno Mdel C, Sierra C Abstract Stroke and diabetes mellitus are two separate conditions which share multiple common threads. Both are increasing in prevalence, both are diseases which affect blood vessels, and both are associated with other vascular risk factors, such as hypertension and dyslipidemia. Abnormal glucose regulation, of which diabetes is one manifestation, is seen in up to two-thirds of people suffering from an acute stroke. Surprisingly, aggressive management of glucose after an acute stroke has not been shown to improve outcome or reduce the incidenc...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks Clinical Sciences
Background and Purpose—Established risk factors do not fully identify patients at risk for recurrent stroke. The SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) evaluated the effect of atorvastatin on stroke risk in patients with a recent stroke or transient ischemic attack and no known coronary heart disease. This analysis explored the relationships between 13 plasma biomarkers assessed at trial enrollment and the occurrence of outcome strokes.Methods—We conducted a case–cohort study of 2176 participants; 562 had outcome strokes and 1614 were selected randomly from those without outcom...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Peter Ganz, Pierre Amarenco, Larry B. Goldstein, Henrik Sillesen, Weihang Bao, Gregory M. Preston, K. Michael A. Welch Tags: Biomarkers, Proteomics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research