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Total 16 results found since Jan 2013.

Days spent at home and mortality after critical illness: a cluster analysis using nationwide data
Chest. 2022 Oct 15:S0012-3692(22)03997-6. doi: 10.1016/j.chest.2022.10.008. Online ahead of print.ABSTRACTBACKGROUND: Beyond the question of short-term survival, days spent at home could be considered a patient-centered outcome in critical care trials.RESEARCH QUESTION: What are the days spent at home and healthcare trajectories during the year after surviving critical illness?STUDY DESIGN AND METHODS: Data were extracted on adult survivors spending at least two nights in a French intensive care unit (ICU) during 2018 who were treated with invasive mechanical ventilation and/or vasopressors or inotropes. Trauma, burn, orga...
Source: Chest - October 18, 2022 Category: Respiratory Medicine Authors: Guillaume L Martin Alice Atramont Marjorie Mazars Ayden Tajahmady Emin Agamaliyev Mervyn Singer Marc Leone Matthieu Legrand Source Type: research

Days spent at home and mortality after critical illness: a cluster analysis using nationwide data
Chest. 2022 Oct 15:S0012-3692(22)03997-6. doi: 10.1016/j.chest.2022.10.008. Online ahead of print.ABSTRACTBACKGROUND: Beyond the question of short-term survival, days spent at home could be considered a patient-centered outcome in critical care trials.RESEARCH QUESTION: What are the days spent at home and healthcare trajectories during the year after surviving critical illness?STUDY DESIGN AND METHODS: Data were extracted on adult survivors spending at least two nights in a French intensive care unit (ICU) during 2018 who were treated with invasive mechanical ventilation and/or vasopressors or inotropes. Trauma, burn, orga...
Source: Chest - October 18, 2022 Category: Respiratory Medicine Authors: Guillaume L Martin Alice Atramont Marjorie Mazars Ayden Tajahmady Emin Agamaliyev Mervyn Singer Marc Leone Matthieu Legrand Source Type: research

Days spent at home and mortality after critical illness: a cluster analysis using nationwide data
Chest. 2022 Oct 15:S0012-3692(22)03997-6. doi: 10.1016/j.chest.2022.10.008. Online ahead of print.ABSTRACTBACKGROUND: Beyond the question of short-term survival, days spent at home could be considered a patient-centered outcome in critical care trials.RESEARCH QUESTION: What are the days spent at home and healthcare trajectories during the year after surviving critical illness?STUDY DESIGN AND METHODS: Data were extracted on adult survivors spending at least two nights in a French intensive care unit (ICU) during 2018 who were treated with invasive mechanical ventilation and/or vasopressors or inotropes. Trauma, burn, orga...
Source: Chest - October 18, 2022 Category: Respiratory Medicine Authors: Guillaume L Martin Alice Atramont Marjorie Mazars Ayden Tajahmady Emin Agamaliyev Mervyn Singer Marc Leone Matthieu Legrand Source Type: research

Contrast agents for photoacoustic imaging: a review of stem cell tracking
Stem Cell Res Ther. 2021 Sep 25;12(1):511. doi: 10.1186/s13287-021-02576-3.ABSTRACTWith the advent of stem cell therapy for spinal cord injuries, stroke, burns, macular degeneration, heart diseases, diabetes, rheumatoid arthritis and osteoarthritis; the need to track the survival, migration pathways, spatial destination and differentiation of transplanted stem cells in a clinical setting has gained increased relevance. Indeed, getting regulatory approval to use these therapies in the clinic depends on biodistribution studies. Although optoacoustic imaging (OAI) or photoacoustic imaging can detect functional information of ...
Source: Cell Research - September 26, 2021 Category: Cytology Authors: Soorya James Kai Neuhaus Mary Murphy Martin Leahy Source Type: research

In-hospital Outcomes of Left Ventricular Assist Devices (LVAD) Patients Undergoing Noncardiac Surgery
An increasing number of stage D heart failure patients are supported with left ventricular assist devices (LVADs), and the management of LVAD patients who require noncardiac surgery (NCS) presents unique challenges. Using the 2010–2014 National Inpatient Sample, we identified all adult cases of LVAD patients undergoing noncardiac surgeries using ICD-9-CM codes. We estimated inpatient mortality, bleeding complications, stroke, length of stay (LOS), and cost of hospitalization of the admissions related to NCS using mixed effects logistic and linear mixed regressions, respectively. A total of 30,323 patients with LVADs unde...
Source: ASAIO Journal - February 1, 2021 Category: Medical Devices Tags: Adult Circulatory Support Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Induced Pluripotent Stem Cells: The Most Versatile Source for Stem Cell Therapy.
This article describes the advantages and hurdles for the use of induced pluripotent cells as the starting material for a source of replacement cells for regenerative medicine. PMID: 30049501 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - July 23, 2018 Category: Drugs & Pharmacology Authors: Glicksman MA Tags: Clin Ther Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Disrupting Today's Healthcare System
This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other count...
Source: Healthy Living - The Huffington Post - November 9, 2015 Category: Consumer Health News Source Type: news

The Man Who Grew Eyes
The train line from mainland Kobe is a marvel of urban transportation. Opened in 1981, Japan’s first driverless, fully automated train pulls out of Sannomiya station, guided smoothly along elevated tracks that stand precariously over the bustling city streets below, across the bay to the Port Island. The island, and much of the city, was razed to the ground in the Great Hanshin Earthquake of 1995 – which killed more than 5,000 people and destroyed more than 100,000 of Kobe’s buildings – and built anew in subsequent years. As the train proceeds, the landscape fills with skyscrapers. The Rokkō mounta...
Source: Science - The Huffington Post - October 11, 2015 Category: Science Source Type: news

Meta-analysis of the association between preoperative anaemia and mortality after surgery.
CONCLUSION: Preoperative anaemia is associated with poor outcomes after surgery, although heterogeneity between studies was significant. It remains unclear whether anaemia is an independent risk factor for poor outcome or simply a marker of underlying chronic disease. However, red cell transfusion is much more frequent amongst anaemic patients. PMID: 26349842 [PubMed - in process]
Source: The British Journal of Surgery - September 12, 2015 Category: Surgery Authors: Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM Tags: Br J Surg Source Type: research

Meta‐analysis of the association between preoperative anaemia and mortality after surgery
ConclusionPreoperative anaemia is associated with poor outcomes after surgery, although heterogeneity between studies was significant. It remains unclear whether anaemia is an independent risk factor for poor outcome or simply a marker of underlying chronic disease. However, red cell transfusion is much more frequent amongst anaemic patients.
Source: British Journal of Surgery - September 9, 2015 Category: Surgery Authors: A. J. Fowler, T. Ahmad, M. K. Phull, S. Allard, M. A. Gillies, R. M. Pearse Tags: Systematic review Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news