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Condition: Heart Disease
Therapy: Stem Cell Therapy
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Total 58 results found since Jan 2013.
Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients with ST-segment Elevation Myocardial Infarction and Left Ventricular Dysfunction: A Multicenter Randomized, Double-Blind and Placebo-Controlled Clinical Trial.
Conclusions: Allogeneic cardiac stem cells can be safely administered in STEMI patients with LV dysfunction early after revascularization. Low immunogenicity and absence of immune-mediated events will facilitate adequately powered studies to demonstrate their clinical efficacy in this setting.Clinical Trial Registration: NCT 02439398.
PMID: 29921651 [PubMed - as supplied by publisher]
Source: Circulation Research - June 19, 2018 Category: Cardiology Authors: Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, Casado Plasencia A, Gilaberte I, Belmans A, Fernández-Santos ME, Charron D, Mulet M, Yotti R, Palacios I, Luque M, Sádaba R, San Roman JA, Larman M, Sánchez PL, Sanchis J, Jimenez-Navarro MF, Claus P, Al-Da Tags: Circ Res Source Type: research
FDA Lays the Smackdown on Illegal Stem Cell Clinics
FDA is cracking down on stem cell clinics that market unapproved products and don't meet good manufacturing practice requirements. On behalf of the agency, the Department of Justice filed two complaints in federal court this week seeking permanent injunctions against a Florida-based clinic and a California-based clinic.
“Cell-based regenerative medicine holds significant medical opportunity, but we’ve also seen some bad actors leverage the scientific promise of this field to peddle unapproved treatments that put patients’ health at risk. In some instances, patients have suffered serious and permanent harm after re...
Source: MDDI - May 10, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news
Therapy-free remission in chronic myeloid leukemia: possible mechanism.
Authors: Gale RP, Hochhaus A
Abstract
Chronic myeloid leukemia (CML) can be cured using tyrosine kinase-inhibitors (TKIs) when cure is defined as achieving a life-expectancy similar or even better than sex- and age-matched persons without CML. Most deaths in persons with CML are now from non-leukemia-related causes including heart disease, diabetes other cancers and stroke. Contrary to expectation, 40-50 percent of persons with CML treated for a few years with TKIs and who achieve a deep molecular response can stop TKI-therapy without leukemia recurrence for several years, some possibly indefinitely. Consequently, ...
Source: Expert Review of Hematology - February 18, 2018 Category: Hematology Tags: Expert Rev Hematol Source Type: research
Scientists Discover a Bone-Deep Risk for Heart Disease
Few doctors, and even fewer patients, have heard of C.H.I.P. But it is emerging as a major cause of heart attacks and stroke, as deadly as high blood pressure or cholesterol.
Source: NYT Health - January 29, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Heart Stem Cells Leukemia Genetics and Heredity Stroke Bone Marrow Blood Arteriosclerosis and Atherosclerosis McCarroll, Steven A (1970- ) Kathiresan, Sekar Walsh, Kenneth Source Type: news
Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions:
We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527
Received: 17 May 2016
Revised: 04 May 2017
Accepted: 09 May 2017
Published: 18 September 2017
Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research
Luteolin: How To Reduce Breast Cancer Risk
More than 100 women die of breast cancer in the U.S. every day. It's the second leading cause of cancer deaths in American women.
But in my opinion, many of those women really die of a tragic medical error. Let me explain…
Millions of women in the U.S. have taken Big Pharma's hormone replacement therapy (HRT). Their doctors prescribe it to try to relieve the symptoms of menopause. Like hot flashes, night sweats, mood swings and weight gain.
But what the drug companies try to pass off as hormones are actually synthetic concoctions. They are fake versions of the estrogen and progesterone that your body makes n...
Source: Al Sears, MD Natural Remedies - June 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Conclusions:
In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. https://doi.org/10.1289/EHP261
Received: 29 March 2016
Revised: 08 August 2016
Accepted: 23 August 2016
Published: 14 June 2017
Address correspondence to X. Wang, Center on the Early Life Origins of Disease, Department of P...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Stem Cell Therapies for Cardiovascular Diseases: What Does the Future Hold?
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality around the globe. In Australia, one in six people are affected by CVD and a total of 4.2 million people are suffering from heart disease, stroke or vascular disease. Coronary artery disease affects around 1.2 million Australians, many of whom develop chronic heart failure as a result of ischaemic cardiomyopathy. The management of CVD has evolved tremendously in the past three decades, but the majority of treatments are not curative.
Source: Heart, Lung and Circulation - January 24, 2017 Category: Cardiology Authors: Hai-Ying Chen, Padraig Michael Strappe, Le-xin Wang Tags: Editorial Source Type: research
Voodoo Medicine: Time To Stop
The world's most celebrated athlete standing on the podium in Rio in honor of receiving yet another gold medal has something important in common with your lazy uncle throwing back a cold one in his Barcalounger. Yes, swimming powerhouse Michael Phelps, purple-spotted from cupping therapy, and your slovenly relative with a beer gut both share a bond -- a weakness in succumbing to the allure of voodoo medicine. Modern-day snake oil salesmen hawking quick cures and TV doctors peddling the latest diet miracle with blatantly ridiculous claims are everywhere on the tube, social media, the supermarket and old-fashioned billboards...
Source: Science - The Huffington Post - August 12, 2016 Category: Science Source Type: news
Lasting Impact of an Ephemeral Organ: The Role of the Placenta in Fetal Programming
Recent advances in molecular and imaging technologies, “omics” fields, and data sciences are offering researchers an unprecedented look at the placenta, the master regulator of the fetal environment.© EPA/National Geographic Channel/Alamy
Studies of infants conceived during the Dutch “Hunger Winter” provided some of the earliest clues that prenatal stress could affect health much later in life.© Nationaal Archief
© Evan Oto/Science Source
In one study, the placental microbiome had a similar taxonomic profile as the oral microbiome, illustrated here by...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News July 2016 Source Type: research
Long Distance Running Effects On Your Health
Long distance running is becoming more and more popular. Close to two million people every year drag themselves across the finish lines. And that’s just in half marathon races. Runners in these 13.1 mile events have increased six-fold over the past 25 years.
All these amateur athletes think they’re getting really healthy as they work themselves up to full marathons. But the truth is they are cutting years off their life.
You can see it for yourself if you stand at the finish line of any race. The hardcore runners look terrible. They look gaunt and malnourished. They are hunched over and have a stiff awkwa...
Source: Al Sears, MD Natural Remedies - June 20, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Fitness Source Type: news
Turmeric: Bali’s Anti-Cancer Tonic
I’m always happy to find things in my travels to bring back to you. Today I want to tell you about a miracle of nature called turmeric.
Turmeric has been used to treat a wide variety of conditions.
You can read about it in-depth in my latest book, Healing Herbs of Paradise.
The roots of this exotic leafy plant contain curcumin, a very powerful antioxidant that also has remarkable anti-inflammatory properties.1,2,3
What Does Curcumin Do?
Curcumin neutralizes free radicals… those nasty little chemicals that travel through your body and cause damage to healthy cells and cell membranes.
Which means curcumin effectivel...
Source: Al Sears, MD Natural Remedies - May 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news
Stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute myocardial infarction. Long-term results of the REVIVAL-2 trial.
In conclusion, these long-term follow-up data show that G-CSF does not improve clinical outcomes of patients with acute myocardial infarction.
PMID: 26790705 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 21, 2016 Category: Hematology Authors: Steppich B, Hadamitzky M, Ibrahim T, Groha P, Schunkert H, Laugwitz KL, Kastrati A, Ott I, Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL-2) Study Investigators Tags: Thromb Haemost Source Type: research
Urine-derived stem cells predict patient response to cholesterol-lowering drugs
High blood cholesterol is linked to an increased risk of heart disease and stroke. To identify new strategies to combat high cholesterol in genetically predisposed individuals, new preclinical models that mimic the underlying pathophysiology are needed. Researchers have now shown that cells derived from patient urine samples can be reprogrammed to rapidly generate patient-specific models of hypercholesterolemia. These models provide a tool to accurately predict patient response to cholesterol-lowering drugs.
Source: ScienceDaily Headlines - November 19, 2015 Category: Science Source Type: news
Disrupting Today's Healthcare System
This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other count...
Source: Healthy Living - The Huffington Post - November 9, 2015 Category: Consumer Health News Source Type: news
