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Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy
BackgroundBoth bone marrow–derived mesenchymal stem cells (MSCs) and c-kit+ cardiac stem cells (CSCs) improve left ventricular remodeling in porcine models and clinical trials. Using xenogeneic (human) cells in immunosuppressed animals with acute ischemic heart disease, we previously showed that these 2 cell types act synergistically.ObjectivesTo more accurately model clinical applications for heart failure, this study tested whether the combination of autologous MSCs and CSCs produce greater improvement in cardiac performance than MSCs alone in a nonimmunosuppressed porcine model of chronic ischemic cardiomyopathy.Metho...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 26, 2015 Category: Radiology Source Type: research

Abstract 1852: Merlin/NF2 is associated with elevated aromatase expression and estrogen formation in human liver tissues and liver cancer cells: An unifying model for hepatocellular carcinoma development and progression
It is recognized that the product of neurofibromatosis type 2 (NF2) tumor suppressor gene, also referred to as Merlin/neurofibromin, is implicated in the homeostatic regulation of the liver stem cell niche through the control of abundance and signaling of epidermal growth factor receptor (EGFR), with a mechanism independent of the Mst/Lats/Yap Hippo pathway [1]. We have previously reported that locally elevated estrogen formation, driven by abnormally high expression and function of the aromatase enzyme, may be implicated in both development and progression of human hepatocellular carcinoma (HCC) through the activation of ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cocciadiferro, L., Miceli, V., Granata, O. M., Carruba, G. Tags: Endocrinology Source Type: research

Nature’s Most Powerful Age Fighter?
When I lecture at anti-aging conferences around the world, I get a good sense of what the leading anti-aging physicians are thinking about. And I’m surprised by how many are still holding out hope for an anti-aging “drug.” But I’m not holding my breath. And even if the FDA approved a drug for aging, it would likely include a laundry list of side effects, and only affect a small range of age-related decline. I’ve always had more faith in nature. Many of the most powerful age fighters are naturally occurring, and they do a better job of supporting and lengthening your telomeres than any drug. Te...
Source: Al Sears, MD Natural Remedies - July 6, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Nutrition omega 3 telomere vitamin C Source Type: news

Traumatic Brain Injuries, Stem Cells and Children: A Conversation With Dr. Charles Cox
One of the world's leading experts on cellular therapies for traumatic brain injury (TBI), Dr. Cox directs the Pediatric Surgical Translational Laboratories and Pediatric Program in Regenerative Medicine at the University of Texas Medical School at Houston, as well as the Pediatric Trauma Program at the University of Texas-Houston/Children's Memorial Hermann Hospital in the Texas Medical Center. He is the author of over 120 scientific publications and 20 book chapters and has served on scientific study sections/review groups for the NIH, American Heart Association, Veterans Affairs MERIT Awards, Department of Defense and C...
Source: Healthy Living - The Huffington Post - February 13, 2015 Category: Consumer Health News Source Type: news

Science Scandal Triggers Suicide, Soul-Searching in Japan
It was a success story that Japan sorely needed: a young, talented and beautiful researcher developed a cheap and simple way to grow versatile stem cells. MoreTokyo: What to See and What to SkipThis Is How TIME Explained the Atomic Bomb in 1945Iselle Weakens to Tropical Storm as Julio Barrels On NBC NewsIsrael Vows to 'Forcefully React' as Cease-Fire Ends NBC NewsCops Tampered With Pistorius Evidence, Lawyer Alleges NBC NewsThe discovery promised to usher in a new age of regenerative medicine, validated Japan as a leader in scientific research and demonstrated that even in a male-dominated society, women could excel when g...
Source: TIME.com: Top Science and Health Stories - August 8, 2014 Category: Consumer Health News Authors: Charlie Campbell Tags: Uncategorized haruko obokata Japan Research Science Stem Cells Suicide Yoshiki Sasai Source Type: news

Stress 'causes damage to the heart,' study finds
Conclusion This research investigates the widely held perceived wisdom that psychological stress is associated with coronary heart disease. It found 29 medical residents working in a stressful intensive care unit setting had increased levels of white blood cells, which form part of the immune system. The researchers also found exposing mice to chronic stress similarly increased their levels of certain white blood cells. When they examined the bone marrow of stressed mice, they found this increase in the number of white blood cells seemed to be mediated by an increase in the activity of hematopoietic stem cells, which prod...
Source: NHS News Feed - June 23, 2014 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Mental health Source Type: news

Racing the clock to help young patients with old hearts
(University of Maryland) University of Maryland biologists used induced plenipotent stem cell technology to discover a destructive cellular process in progeria, a rare genetic disorder that causes premature aging. Patients die in their teens of heart disease or stroke. Assistant professor Kan Cao discovered that progerin, a toxic protein, causes smooth muscle cells in patients' arteries to self-destruct. The finding speeds testing of progeria treatments and could shed light on normal aging.
Source: EurekAlert! - Social and Behavioral Science - May 19, 2014 Category: Global & Universal Source Type: news

Stem cell therapy for chronic ischaemic heart disease and congestive heart failure.
CONCLUSIONS: This systematic review and meta-analysis found moderate quality evidence that BMSC treatment improves LVEF. Unlike in trials where BMSC were administered following acute myocardial infarction (AMI), we found some evidence for a potential beneficial clinical effect in terms of mortality and performance status in the long term (after at least one year) in people who suffer from chronic IHD and heart failure, although the quality of evidence was low. PMID: 24777540 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 3, 2014 Category: Journals (General) Authors: Fisher SA, Brunskill SJ, Doree C, Mathur A, Taggart DP, Martin-Rendon E Tags: Cochrane Database Syst Rev Source Type: research

Fat chance: Scientists unexpectedly discover stress-resistant stem cells in adipose tissue
Researchers from the UCLA Department of Obstetrics and Gynecology have isolated a new population of primitive, stress-resistant human pluripotent stem cells that are easily derived from fat tissue and are able to differentiate into virtually every cell type in the human body without genetic modification.   The cells, called multi-lineage stress-enduring stem cells from adipose tissue (Muse-AT), were discovered by "scientific accident" when a piece of equipment failed in the laboratory, killing all the stem cells in an experiment except the Muse-AT cells.   The UCLA team further discovered that not only are Muse-A...
Source: UCLA Newsroom: Health Sciences - June 5, 2013 Category: Universities & Medical Training Source Type: news

Predictive Risk Factors of In-Hospital Mortality Following Acute Stroke in the United States: Data from the Nationwide Inpatient Database, 2006-2010 (P02.015)
CONCLUSIONS: The rate of in-hospital mortality is relatively high following acute stroke (8.42%). We identified multiple risk factors of in-hospital mortality in acute stroke patients. The strongest risk factor is the type stroke (hemorrhagic). The present finding suggests that patients at increased risk of mortality can be identified and additional treatment for prevention might be warranted.Disclosure: Dr. Naderi has nothing to disclose. Dr. Abcede has nothing to disclose. Dr. Al-Khoury has nothing to disclose. Dr. Mozaffar has received personal compensation for activities with California Stem Cell Inc., NuFactor, Cresce...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Naderi, N., Abcede, H., Al-Khoury, L., Mozaffar, T., Jain, V. Tags: P02 Cerebrovascular Disease II Source Type: research

Final agenda available for CRF sponsored conference on stem cell therapy for heart disease
(Cardiovascular Research Foundation) The Eighth International Conference on Cell Therapy for Cardiovascular Disease, sponsored by the Cardiovascular Research Foundation, will be held Jan. 23-25, 2013. The conference is the premier meeting dedicated to the evolving field of cell-based therapies for the repair and regeneration of cardiac and vascular disease, as well as related diseases such as diabetes and stroke.
Source: EurekAlert! - Medicine and Health - January 17, 2013 Category: Global & Universal Source Type: news

Agenda set for upcoming CRF-sponsored conference on stem cell therapy for heart disease
(Cardiovascular Research Foundation) The 8th International Conference on Cell Therapy for Cardiovascular Disease, sponsored by the Cardiovascular Research Foundation will be held Jan. 23-25, 2013. The conference is a comprehensive program dedicated to the evolving field of cell-based therapies for the repair and regeneration of cardiac and vascular disease, as well as related diseases such as diabetes and stroke.
Source: EurekAlert! - Medicine and Health - January 3, 2013 Category: Global & Universal Source Type: news

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

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