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Condition: Brain Tumor

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Total 780 results found since Jan 2013.

A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders
This study depicts the relationship of chrysin with different brain related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders, based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.PMID:35657041 | DOI:10.2174/1871527321666220602111935
Source: CNS and Neurological Disorders Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Ahsas Goyal Geetanjali Singh Aanchal Verma Source Type: research

Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology
Epilepsy Behav. 2022 May 25;132:108739. doi: 10.1016/j.yebeh.2022.108739. Online ahead of print.ABSTRACTThe incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age. The most common syndromes in these demographics - self-limited epilepsies of childhood and idiopathic generalized epilepsies in pediatric age, focal epilepsy with structural etiology in older people - are expected to be drug responsive. In this work, we focus on such epilepsy types, overviewing the complex clinical background of unexpected drug-resistance. For self-limited epilepsies of childhood and idiopathic generalized epilepsi...
Source: Epilepsy and Behaviour - May 31, 2022 Category: Neurology Authors: Emanuele Bartolini Anna Rita Ferrari Simona Lattanzi Silvia Pradella Gaetano Zaccara Source Type: research

Recent Synergy of Nanodiamonds: Role in Brain-Targeted Drug Delivery for the Management of Neurological Disorders
AbstractThe aim of the present review article is to summarize the role of nanodiamonds in various neurological diseases. We have taken related literature of making this review article from ScienceDirect, springer, Research gate, PubMed, Sci-finder, etc. The current approaches for treating neurological conditions such as glioblastoma includes chemotherapy or combination anti-retro viral therapy for HIV (human immunodeficiency virus) or use of anti-Alzheimer drugs during cognitive impairment. These approaches can provide only symptomatic relief as they do not target the cause of the disease due to their inability to penetrat...
Source: Molecular Neurobiology - May 27, 2022 Category: Neurology Source Type: research

The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks
Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical pa...
Source: Frontiers in Human Neuroscience - May 16, 2022 Category: Neuroscience Source Type: research

Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors
Conclusions This technique of perfusion guided-ESIA injections (PG-ESIA) enhances our ability to perform targeted super-selective delivery of therapeutic agents for brain tumors.
Source: Journal of NeuroInterventional Surgery - May 13, 2022 Category: Neurosurgery Authors: Chen, S. R., Chen, M. M., Ene, C., Lang, F. F., Kan, P. Tags: Editor''s choice New devices and techniques Source Type: research

Diagnosis and Management of Stroke in Adults with Primary Brain Tumor
This article reviews the risk factors, clinical presentations, differential diagnosis, and the types of strokes frequently seen in patients with primary brain neoplasms. This includes a discussion of approaches with a review of the available literature and provides recommendations for primary and secondary prevention specific to this patient population.Recent FindingsStrokes in patients with brain tumors are often multifactorial. However, tailored approaches to stroke care are necessary to achieve optimal patient outcomes, AHA/ASA stroke guidelines provide little information on the management of stroke in cancer patients. ...
Source: Current Oncology Reports - May 11, 2022 Category: Cancer & Oncology Source Type: research

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches
Brain Struct Funct. 2022 May 3. doi: 10.1007/s00429-022-02494-x. Online ahead of print.ABSTRACTGliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas-based) approaches to quantifying WM structural disconnections in a cohort of 44 high- and low-grade glioma patients. While these metho...
Source: Brain Structure and Function - May 3, 2022 Category: Neuroscience Authors: Erica Silvestri Umberto Villani Manuela Moretto Maria Colpo Alessandro Salvalaggio Mariagiulia Anglani Marco Castellaro Silvia Facchini Elena Monai Domenico D'Avella Alessandro Della Puppa Diego Cecchin Maurizio Corbetta Alessandra Bertoldo Source Type: research

Imaging subtle leaks in the blood –brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions
AbstractRecent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood –brain barrier (BBB) leaks in the human brain during normal aging, in individuals with age-related cognitive dysfunction, genetic risk for Alzheimer’s disease (AD), mild cognitive impairment, early AD, cerebral small vessel disease (SVD), and other neurodegenerative disorders. In these neurologi cal conditions, the BBB leaks, quantified by the unidirectional BBB GBCA tracer’s constantKtrans maps, are typically orders of magnitude lower than in brain tu...
Source: AGE - April 25, 2022 Category: Geriatrics Source Type: research

Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
Acta Biomed. 2022 Mar 21;92(S4):e2021417. doi: 10.23750/abm.v92iS4.12666.ABSTRACT ABSTRACT Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury), which, in addition to neuro-protective effects, can mediate secondary neurological injury. The neutrophil-to-lymphocyte ratio (NLR), as a circulating inflammatory marker, has been related to outcomes in adult patients with non-neurologic d...
Source: Acta Bio-Medica : Atenei Parmensis - April 20, 2022 Category: General Medicine Authors: Pietro Marchese Chiara Lardone Alessia Canepele Samanta Biondi Costantino Roggi Francesco Massart Alice Bonuccelli Diego Peroni Alice Giotta Lucifero Sabino Luzzi Thomas Foiadelli Alessandro Orsini Source Type: research