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Total 20589 results found since Jan 2013.

Diagnostic ability of Japanese version of high bleeding risk criteria for ischemic outcomes in patients with acute myocardial infarction
AbstractThe Japanese version of high bleeding risk (J-HBR) criteria was domestically proposed to identify patients at HBR after percutaneous coronary intervention (PCI). The applicability of J-HBR on bleeding events has been validated, while whether J-HBR predicts ischemic events is uncertain. This bi-center registry included 904 patients with acute myocardial infarction (MI) undergoing primary PCI. Patients were stratified by the J-HBR major (1 point) and minor (0.5 point) criteria. Patients with J-HBR ≥ 1 point were diagnosed as having HBR. The primary endpoint was major adverse cardiovascular events (MACE), a com...
Source: Heart and Vessels - August 20, 2023 Category: Cardiology Source Type: research

Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with severe isolated tricuspid regurgitation: comparison with fibrosis-4 index
AbstractThe fibrosis-4 index (FIB4), a liver fibrosis maker, has been shown to be associated with the prognosis in patients with severe isolated tricuspid regurgitation (TR). Recent study showed that the fibrosis-5 index (FIB5), which was calculated by albumin, alkaline phosphatase, aspartate transaminase, alanine aminotransferase and platelet count, had better prognostic value than FIB4 in patients with heart failure. The aim of this study was to evaluate the usefulness of FIB5 index for predicting prognosis in patients with severe isolated TR and compare the prognostic value between the FIB4 and the FIB5 in those patient...
Source: Heart and Vessels - August 19, 2023 Category: Cardiology Source Type: research

Age and sex differences in the risk of cardiovascular diseases by chronic kidney disease in a general Japanese population
We examined 5163 subjects who underwent health screening between 1992 and 1995 with calculated eGFR and follow-up information on CVD events. The mean follow-up period was 10 years. We analyzed the incidences of CVD events, including stroke and myocardial infarction (MI). We compared the risk of CVD between subjects with and without CKD using a Cox proportional hazards model adjusted for well-known CVD confounding factors. The total number of CVD events was 175. The h azard ratios (HRs) for all events, stroke, MI, and sudden death by CKD relative to non-CKD were 1.18 (95% C.I.:0.83–1.68), 0.96 (0.63–1.46), 3.02 (1.2�...
Source: Heart and Vessels - August 19, 2023 Category: Cardiology Source Type: research

Cardiovascular comorbidities in atopic dermatitis: Potential implications for the use of Janus kinase inhibitors
To the Editor: The Food and Drug Administration recently approved the use of 2 oral Janus kinase (JAK) inhibitors —abrocitinib and upadacitinib—for patients with moderate-to-severe atopic dermatitis (AD) not adequately controlled with systemic therapies, including biologics, or when the use of such treatments is inadvisable.1,2 In September 2021, the Food and Drug Administration issued a boxed warning for a ll JAK inhibitors regarding the increased risk of serious infections, heart attack, stroke, cancer, blood clots, and death.
Source: Journal of the American Academy of Dermatology - August 19, 2023 Category: Dermatology Authors: J. Mark Jackson, Amanda Althoff, Lawrence Rasouliyan, Stacey Long, Carla L. Zema Tags: Research letter Source Type: research

Predictive value of Killip classification in MINOCA patients
CONCLUSIONS: Killip classification confirmed its prognostic impact on short- and long-term outcomes also in a selected MINOCA population, which still craves for a baseline risk stratification.PMID:37596114 | DOI:10.1016/j.ejim.2023.08.011
Source: European Journal of Internal Medicine - August 18, 2023 Category: Internal Medicine Authors: Matteo Armillotta Sara Amicone Luca Bergamaschi Francesco Angeli Andrea Rinaldi Pasquale Paolisso Andrea Stefanizzi Angelo Sansonetti Andrea Impellizzeri Francesca Bodega Lisa Canton Nicole Suma Damiano Fedele Davide Bertolini Alberto Fo à Carmine Pizzi Source Type: research

Effect of Beta-Blocker on Long-Term Major Cardiovascular Events in High Atherosclerotic Risk Population
CONCLUSION: In patients with high atherosclerotic cardiovascular risk, taking beta-blockers had a higher risk of 3P-MACEs. Care should be taken when prescribing beta-blockers to patients without a clear indication.TRIAL REGISTRATION: TCTR20130520001 registered in Thai Clinical Trials Registry (TCTR) https://www.thaiclinicaltrials.org/ , date of registration 20 May 2013.PMID:37594650 | DOI:10.1007/s10557-023-07502-8
Source: Atherosclerosis - August 18, 2023 Category: Cardiology Authors: Nichanan Osataphan Kamol Udol Khanchai Siriwattana Bancha Sukanandachai Siriluck Gunaparn Wachiranun Sirikul Arintaya Phrommintikul Wanwarang Wongcharoen Source Type: research

Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers are Associated With Improved Amputation Free Survival in Chronic Limb-threatening Ischemia
In the Heart Outcomes Prevention Evaluation (HOPE) study, investigators found that ramipril was associated with improved survival as well as decreased myocardial infarction (MI) and stroke rates in patients with peripheral arterial disease. Nonetheless, their effect on chronic limb-threatening ischemia (CLTI)-specific outcomes is unclear. We aim to assess the effect of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) on amputation-free survival in patients with CLTI undergoing peripheral vascular intervention (PVI) in a Medicare-linked database.
Source: Journal of Vascular Surgery - August 18, 2023 Category: Surgery Authors: Nadin Elsayed, Darrin Clouse, Raghu L. Motaganahalli, Mahmoud Malas Source Type: research

Effect of Beta-Blocker on Long-Term Major Cardiovascular Events in High Atherosclerotic Risk Population
ConclusionIn patients with high atherosclerotic cardiovascular risk, taking beta-blockers had a higher risk of 3P-MACEs. Care should be taken when prescribing beta-blockers to patients without a clear indication.Trial registrationTCTR20130520001 registered in Thai Clinical Trials Registry (TCTR)https://www.thaiclinicaltrials.org/, date of registration 20 May 2013.
Source: Cardiovascular Drugs and Therapy - August 18, 2023 Category: Cardiology Source Type: research

Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research

Epidemiology of cardiovascular disease in Japan: An overview study
J Cardiol. 2023 Aug 15:S0914-5087(23)00200-9. doi: 10.1016/j.jjcc.2023.08.006. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs), such as heart disease and stroke, have a significant impact on life expectancy, healthy life expectancy, and medical costs in Japan. Each prefecture is currently promoting measures in accordance with the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, which was established by the government. In recent years, the crude mortality rate of heart disease in Japan has been increasing year by year with the aging population. Meanwhile, the ...
Source: Journal of Cardiology - August 17, 2023 Category: Cardiology Authors: Tetsuya Ohira Eri Eguchi Fumikazu Hayashi Minako Kinuta Hironori Imano Source Type: research

The role of macrophage ion channels in the progression of atherosclerosis
Front Immunol. 2023 Jul 31;14:1225178. doi: 10.3389/fimmu.2023.1225178. eCollection 2023.ABSTRACTAtherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regul...
Source: Atherosclerosis - August 17, 2023 Category: Cardiology Authors: Xin Wu Sidhant Singla Jianhua J Liu Liang Hong Source Type: research

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