Age and sex differences in the risk of cardiovascular diseases by chronic kidney disease in a general Japanese population

We examined 5163 subjects who underwent health screening between 1992 and 1995 with calculated eGFR and follow-up information on CVD events. The mean follow-up period was 10  years. We analyzed the incidences of CVD events, including stroke and myocardial infarction (MI). We compared the risk of CVD between subjects with and without CKD using a Cox proportional hazards model adjusted for well-known CVD confounding factors. The total number of CVD events was 175. The h azard ratios (HRs) for all events, stroke, MI, and sudden death by CKD relative to non-CKD were 1.18 (95% C.I.:0.83–1.68), 0.96 (0.63–1.46), 3.02 (1.2–7.62), and 1.29 (0.43–3.87), respectively. HRs for MI were 7.24 in subjects <  65 years and 1.65 in those ≥ 65 years. HRs for MI by sex were 3.55 in men and 2.09 in women. A younger age and men sex were identified as independent risk factors for the risk of MI in the presence of CKD. These results suggest that among CKD patients, the management of a younger age grou p and men will effectively prevent MI.
Source: Heart and Vessels - Category: Cardiology Source Type: research